@article {2012, title = {Complete Blood Profile after administration of Hydrocotyle sibthorpioides Lam. extract in capsule form}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {April 2023}, pages = {375-383}, type = {Research Article}, chapter = {375}, abstract = {

Pegagan embun (Hydrocotyle sibthorpioides Lam.) has been studied as an immunostimulant, increasing macrophage cell activity and phagocytosis capacity. Based on that circumstance, the study aims to prove the immunostimulating effect by measuring the activity of Hydrocotyle sibthorpioides Lam. extract in the capsule for the complete blood profile of healthy volunteers. The number of volunteers used was twenty people, and the volunteers were divided into two groups. The first group was given a placebo capsule without Hydrocotyle sibthorpioides Lam. extract. The second group was given a capsule with Hydrocotyle sibthorpioides Lam. extract with a dose of 67 mg, which was taken once a day for three days. Blood sampling was obtained before and after taking the capsule preparation. Observation of the complete blood profile was conducted by investigating changes in blood parameters such as haemoglobin levels, number of erythrocytes, number of leukocytes, hematocrit values, number of thrombocytes and the percentage of leukocyte types (banded neutrophils, segmented neutrophils, eosinophils, basophils, monocytes, and lymphocytes). The second group given Hydrocotyle sibthorpioides Lam. extract showed a significant effect on the increase in haemoglobin levels, number of thrombocytes and hematocrit values (p\<0.05). The percentage of leukocyte type values showed that lymphocytes increased significantly (p\<0.05). In contrast, the segmented neutrophil increased but did not show a significant difference with the percentage of banded neutrophils, eosinophils, basophils and monocytes (p\>0.05). There was a nonsignificant result in all parameters for the first group, which was administrated with a placebo capsule without Hydrocotyle sibthorpioides Lam. extract.

}, keywords = {Banded neutrophil, Basophils, Eosinophils, erythrocytes, Haematology, Haemoglobin, Hematocrit, Hydrocotile sibthorpioides Lam., Immunostimulants, Leukocytes, Lymphocyte, Monocytes, Segmented neutrophil, Thrombocytes.}, doi = {10.5530/pj.2023.15.58}, author = {Afriwardi and Adrul Fauzan and Salman Umar and Yufri Aldi} } @article {1606, title = {Ethanol Extract Activity of Pegagan Embun (Hydrocotyle sibthorpioides L.) Against Hematopoietic on Anemic Male White Mice}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {July 2021}, pages = {866-873}, type = {Original Article}, chapter = {866}, abstract = {

Introduction: Pegagan embun (Hydrocotyle sibthorpioides L.) is known to have many benefits, including as a blood booster. This study aims to determine the activity of pegagan embun (Hydrocotyle sibthorpioides L.) on the formation of red blood cells. The parameters include the number of erythrocytes, reticulocytes, hemoglobin levels, and hematocrit values in anemic male white mice induced by chloramphenicol 130 mg/kg for 14 days. Methods: Anemic mice consisted of 4 groups, namely the first group was given physiological NaCl, the second, third, and fourth groups were given ethanol extract of pegagan embun (Hydrocotyle sibthorpioides L.) at a dose of 10, 50 and 100 mg/kgper oral every day, for 14 days. Observations were made on days 0, 14, 21, and 28. Results: The results showed that administration of pegagan embun extracts at a dose of 10, 50, and 100 mg/kgto anemic male white mice significantly increase the number of erythrocyte cells, the number of reticulocytes, the hemoglobin levels, and the hematocrit values (p \<0.05). Increasing the dose and duration of pegagan embun extract administration could provide a more significant increase in the hematopoietic parameters (p \<0.05). Conclusion:It can be concluded that the extract of pegagan embun (Hydrocotyle sibthorpioides L.) can be used to treat anemia in male white mice.

}, keywords = {erythrocytes, Extract of Hydrocotyle sibthorpioides L., Hematocrit, Hemoglobin, Reticulocytes}, doi = {10.5530/pj.2021.13.111}, author = {Elidahanum Husni and Dwisari Dillasamola and Elsa Badriyya and Resta Angelia and Yufri Aldi} } @article {1516, title = {Protective Effects of Beetroot Extract against Phenyl Hydrazine Induced Anemia in Rats}, journal = {Pharmacognosy Journal}, volume = {6}, year = {2014}, month = {2nd July 2014}, pages = {1-4}, type = {Original Article}, abstract = {

Background: Anemia can be regarded as one of the oldest blood malformation known over a century. Megaloblastic anemia arises due to curtailed formation of erythrocytes, which leads to formation of a large number of underdeveloped erythrocytes. Proper nutritional supplementation may be useful in such condition. Beta vulgaris or beetroot is one of the important vegetables consumed worldwide. The aim of the present work was to evaluate anti-anemic potential of beetroot. Methods: Beetroot was extracted with ethanol. Phytochemical and phytoanalytical studies were performed on extract. Anemia was induced by phenyl-hydrazine. Animals were treated with extract throughout the study for 24 days. The red blood cell (RBC) number and hemoglobin concentration were determined every 3 days for 24 days. Results: Extract was found to be rich in folic acid, ascorbic acid, and iron. Following the induction of anemia, the number of erythrocytes and the hemoglobin concentration decreased by 62.51\% and 69.64\%, respectively. Administration of standard hematinic preparation and extract (200 mg/kg) resulted in signifi cant increase (P\< 0.001; P\< 0.01) in the number of RBCs as well as hemoglobin concentration when compared to the untreated phenyl hydrazine-induced anemic rats. Conclusion: Extract effectively raised the level of hemoglobin and erythrocyte count at dose 200 mg/kg. Vitamin and minerals found in beetroot are most likely active ingredients responsible for its hematinic effects. Still, methodical studies are obligatory to derive its effects on humans.

Key words:Beta vulgaris, erythrocytes, hemoglobin, phenyl hydrazine.

}, keywords = {Beta vulgaris, erythrocytes, Hemoglobin, phenyl hydrazine}, author = {Anupam Jaiswal and Aditya Ganeshpurkar and Ankita Awasthi and Divya Bansal and Nazneen Dubey} }