@article {1502, title = {Estrogenic Activity of Bauhinia racemosa extract in Female albino rats: An Investigational Study}, journal = {Pharmacognosy Journal}, volume = {6}, year = {2014}, month = {3rd Sept, 2014}, pages = {5-9}, type = {Original Article}, chapter = {5}, abstract = {

Objective: To evaluate the effect of petroleum ether, ethanol and water extract of Bauhinia racemosa in female albino rats. Methods: Plant extracts were tested for their estrogenic activity by using ovariectomised method at two dose level: 200 mg/kg and 400mg/kg respectively. Further, Plant extracts and Standard drug Ethinyl estradiol (1\µg/kg) combination were tested for synergistic estrogenic activity. Results:In-vivo investigation revealed that ethanol extract at dose of 200 mg/kg and 400 mg/kg shows significance increase 325.23\±5.23, 328.84\±4.56 and 3.252\±0.47, 3.288\±0.27 in uterine wet weight and uterine weight ratio respectively in female albino rat as compared to control and petroleum ether and water extracts. Simultaneous administration of standard drug Ethinyl estradiol (1\µg/kg) with ethanol extract at dose of 200 mg/kg and 400 mg/ kg potentiates (327.36 \± 5.78, 330.95 \± 6.21 and 3.273 \± 0.64, 3.309 \± 0.49 uterine wet weight and uterine weight ratio respectively in female albino rat) the estrogenic activity as compared to individual administration of ethanol extract as a synergistic effect. Conclusion: It was observed that ethanol extract of Bauhinia racemosa produced significance estrogenic activity.

Key words:Bauhinia racemosa, estrogenic activity, Ethinyl estradiol, ovariectomy.

}, keywords = {Bauhinia racemosa, Estrogenic activity, Ethinyl estradiol, ovariectomy.}, author = {Gautam P. Vadnere and Aslam R. Pathan and Abhay K. Singhai} }