@article {2171, title = {Extract of Torbangun (Coleus amboinicus Lour) Leaves Inhibits the Expression of PEPCK and G6Pase in Streptozotocin-Induced Diabetic Rats}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {December 2023}, pages = {1116-1120}, type = {Research Article}, chapter = {1116}, abstract = {

Objective: This study aimed to analyze the anti-hyperglycemic activity of Torbangun leaf extract (TLE) in hyperglycemic rats by observing its effect on blood glucose levels and PEPCK and G6Pase gene expression. Method: This post-test-controlled group design study used a completely randomized design (CRD). Seven rats were separated as a normal group (N) and other rats were injected with streptozotocin (STZ). Hyperglycemia was characterized by fasting blood glucose (FBG) \>126 mg/dl. Hyperglycemic rats were divided into three groups: H-IM (control drug metformin hydrochloride dose 62.5 mg/kg BW), H-IT (TLE dose 620mg/kg BB), and NG (negative control, hyperglycemic rats). Rats were given intervention for 14 days. Result: The results showed a significant difference between initial and final FBG of the HI-IM group (p = 0.002, α = 0.01) and the H-IT group (p = 0.005, α = 0.01) and effect on the key gene expression of gluconeogenesis in the liver. The H-IT group showed a decrease in PEPCK gene expression 0.80 times and decreased G6Pase gene expression by 0.65 times compared to NG group. Conclusion: The findings suggested the administration of TLE in STZ-induced hyperglycemic rats was able to reduce blood sugar levels and was involved in inhibiting the expression of PEPCK and G6Pase expression genes in the liver.

}, keywords = {G6Pase, hyperglycemia, PEPCK, Rats, Torbangun}, doi = {10.5530/pj.2023.15.203}, author = {Meilla Dwi Andrestian and Rizal Damanik and Faisal Anwar and Nancy Dewi Yuliana and Anwar Mallongi} } @article {1486, title = {Assessment of anti hyperglycemic fractions isolated from Albizia procera stem bark chloroform extract using STZ induced diabetic albino rats}, journal = {Pharmacognosy journal}, volume = {6}, year = {2014}, month = {8th April 2014}, pages = {29-35}, type = {Original Article}, abstract = {

Objective: The present Study was to identify more effective hypoglycemic fractions from chloroform extract of Albizia procera stem bark. Material and methods: Isolated fractions of Albizia procera stem bark chloroform extract were given individually to different batches of rats both normal (80 mg/kg of b.wt animals) and STZ induced diabetic rats (160mg/kg b.wt animals) after an overnight fast. The blood glucose levels were measured at 0, 1, 2, 3, 5 and 6 hours after the treatment. Fractions were also treated to STZ induced diabetic rats by chronically (80mg/kg b.wt). Results: The fractions E of Albizia procera stem bark chloroform extract was shown maximum blood glucose lowering effect in both normal and STZ diabetic rats with acute and chronic treatment. The other fractions are also showing hypoglycemic and antihyperglycemic activity, but the effect is significantly less than that of fraction E. The antihyperglycemic activity of fractions of Albizia procera stem bark chloroform extract was compared with the treatment of glibenclamide. Conclusion: The present data confirm the anti diabetic activity of Albizia procera in Indian traditional medicine for Diabetes mellitus treatment. The anti hyperglycemic action attributed to the presence of valuable flavonoids, terpinoids in the fraction E.

Key words: Albizia procera, hyperglycemia, Streptozocin (STZ).

}, keywords = {Albizia procera, hyperglycemia, Streptozocin (STZ)}, author = {Praveen kumar P, and Ramesh A, and Prasad K} }