@article {2475, title = {The Mechanism of Nanocurcumin in Inhibiting Parasitemia in Plasmodium berghei ANKA (PbA) Model Mice}, journal = {Pharmacognosy Journal}, volume = {17}, year = {2025}, month = {January 2025}, pages = {84-88}, type = {Research Article}, chapter = {84}, abstract = {

Plasmodium falciparum is the cause of malaria falciparum, the most severe type of malaria, and the only malaria parasite that can cause complications such as microvascular disease, cerebral malaria, severe anemia, shock, acute renal failure, and shortness of breath. In Southeast Asia, Indonesia has the highest incidence of malaria. The WHO estimated that in 2019, there were 658,380 malaria cases and 1,170 malariarelated deaths. Curcumin (Curcuma longa) is a spice that has been used in Southeast Asia for centuries. It contains the active ingredient curcumin (bis-α, β-unsaturated β-diketone), which has antioxidant, antiinflammatory, hepatoprotective, and antimalarial properties. However, curcumin has low water solubility and very limited bioavailability. By examining the observed phenomenon, it is possible to investigate how nanocurcumin might impact parasitemia levels in P. berghei ANKA model mice. This research involved 36 female BALB/c mice aged 7{\textendash}10 weeks, divided into four groups, all of which were infected with P. berghei ANKA. After infection, the groups were treated for 2 weeks as follows: the control group (no nanocurcumin administered), treatment group I (50 mg/kg body weight [kgbw]), treatment group II (100 mg/kgbw), and treatment group III (150 mg/kgbw). The results indicated a significant difference among groups (p \< 0.05, 0.036). The conclusion of this experiment is that administering nanocurcumin to mice infected with the Plasmodium parasite significantly reduces parasitemia levels in the blood, particularly at a dose of 150 mg/kgbw.

}, keywords = {Nanocurcumin, Parasitemia, Plasmodium berghei Anka}, doi = {10.5530/pj.2025.17.11}, author = {Risma R and Aryati A and Bambang Purwanto} } @article {1397, title = {The Anti-Malarial Effect of Thespesia populnea (L.) Soland ex Correa Extract Using Malaria Mice Model Infected with P. berghei}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {March 2021}, pages = {585-590}, type = {Research Article}, chapter = {585}, abstract = {

Introduction: Malaria is a re-emerging disease that still causes high morbidity and mortality rates. Reports of malaria therapy, encouraging studies to find new therapies based on plants and adjuvant in malaria infection. Thespesia populnea or portia tree leaf extract is a plant that has been shown to have anti-inflammatory, antibacterial and antifungal effects. The aim of this study was to analyze the effect of Thespesia populnea leaf extract as antimalarial levels, and and its effect on hemoglobin levels in BALB/C mice infected with Plasmodium berghei ANKA (PbA). Methods: The study was true experimental laboratories using post-test only group design. Using 27 mice were randomly divided into 3 groups: Group with aquades (G1), Group received Chloroquine (G2), and Group with 200 mg/kg bw of Thespesia populnea (L.) Soland ex Correa extract and Chloroquine (G3). The degree of parasitemia was observed serially from the first day to the fourth day. Observation of the number of leukocytes and hemoglobin on the fourth day after the mice were terminated. Results: The results of statistical analysis showed that the administration of Thespesia populnea leef extract 200 mg/kg bw with chloroquine had the effect of decreasing the degree of parasitemia and increasing hemoglobin significantly than G1 group, but there was no significant difference with G2 group, although descriptively there were differences. Conclusion: Based on the results of this study, it can be concluded that Thespesia populnea or portia tree leaf extract has an anti-malarial effect and can also significantly prevent anemia.

}, keywords = {BALB/C, Hemoglobin, Malaria, Parasitemia, Thespesia populnea extract}, doi = {10.5530/pj.2021.13.73}, author = {Prawesty Diah Utami and Herin Setianingsih and Indira Firdha Syafitri and Rico Pratama Wiyono} }