@article {1847, title = {Radiographic and Histological Evaluation in Canine Femur after Implantation of 304 Stainless-steel-based Plate}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {August 2022}, pages = {388-392}, type = {Research Article }, chapter = {388}, abstract = {

Fractures are known to be high-risk traumatic cases in domestic animals. Surgery was performed to reposition and immobilize bone using a plate as a biomaterial component. This study aimed to evaluate the radiographic and histological findings in canine femur after implantation of a 304 stainless-steel-based plate. A total of six male dogs aged 3-4 months were used in this study. Dogs were acclimatized for a week and then randomly assigned to 2 groups and 3 replication, respectively. The left femoral diaphysis was cracked and fixed by (A) commercial plate; (B) 304 stainless-steel plate. Radiographic observations were performed at 24 h and 28 d postoperatively during the recovery period. Histological figures were evaluated at 28 d postoperative descriptively. As a result, physical examination of muscle tissue in both groups did not reveal discoloration, swelling, and fluid accumulation around the plate. The radiographic figures presented a slight callus production around the crack and a decrease in the gap between cracks after 28 d. The histological figures observed the proliferation of osteoblasts, osteocytes, connective tissues, and bone trabeculae. It can be concluded that no significant difference between 304 stainlesssteel plate compared to commercial plate. A 304 stainless-steel-based plate is recommended for bone immobilization in canine femoral fractures.

}, keywords = {304 stainless-steel, Domesticated animal, Femur, Fracture, Radiograph}, doi = {10.5530/pj.2022.14.112}, author = {Agus Purnomo and Hartiningsih and Setyo Budhi and Dhirgo Adji and Devita Anggraeni and Dito Anggoro and Sitarina Widyarini and Shekhar Chhetri and Muhammad Thohawi Elziyad Purnama} } @article {1305, title = {The Role of Recombinant Parathormone derivative in Bone healing. Making the Unfavorable, Favorable - A Systematic Review}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {November 2020}, pages = {1753-1768}, type = {Review Article}, chapter = {1753}, abstract = {

Background: Teriparatide is a recombinant parathormone derivative encompassing the first 1-34 amino acids off PTH, which is said to contain potent anabolic capability. It is said to induce osteoblastogenesis thereby placing an essential role in bone healing. The aim of this systematic review is to evaluate the best available evidence from randomized controlled trials analyzing the effectiveness of teriparatide on bone regeneration and healing in osteoporotic patients and patients with fractures. Aim: This systematic review aims to assess whether Teriparatide enhances bone regeneration and healing in terms of improving clinical, radiographic, histologic parameters and Biomarkers of Bone formation and resorption. Materials and Methodology: A comprehensive search was done in databases such as {\textquoteleft}PubMed{\textquoteright}, {\textquoteleft}Google Scholar and {\textquoteleft}Cochrane{\textquoteright} databases based on pre-determined eligibility criteria. Randomized control trials assessing the effectiveness of Teriparatide in Bone healing in fractures as well as osteoporosis were selected after thorough screening. Results: The selected 13 studies compared teriparatide to either placebo or another anti-resorptive drug. Out of the 13, 8 studies were done to evaluate the improvement and healing of bone in Osteoporotic patients whereas 5 studies were done on improvement in fracture healing. The studies evaluated outcome parameters such as Clinical and Radiological improvement, Biomarkers of Bone resorption and formation and Safety.6 studies assessed clinical parameters, 12 studies assessed radiological parameters, 7 studies assessed biomarkers, 11 studies assessed safety parameters by means of occurrence of any adverse effects. All the 8 studies done on osteoporotic patients showed a good improvement. Of the 5 studies on fracture healing, only 2 studies showed beneficial effects while the other 3 did not show any benefits. Conclusion: Teriparatide could have beneficial effects in bone healing in osteoporotic patients and is well tolerated. However, the results are inconclusive whether they have beneficial effects in treating fractures. More Homogenous Randomized control trials are required to ascertain whether teriparatide could improve bone healing.

}, keywords = {Bone healing, Fracture, Parathormone, Recombinant derivative, Teriparatide}, doi = {10.5530/pj.2020.12.238}, author = {S Swarna Meenakshi and Sheeja S Varghese} }