@article {2489, title = {Preparation, Characterization and Wound Healing Effect of β Chitosan and Gelatin Hydrogels from Sepia Officinalis: In Vivo Study}, journal = {Pharmacognosy Journal}, volume = {17}, year = {2025}, month = {April 2025}, pages = {244-251}, type = {Research Article}, chapter = {244}, abstract = {

Wound healing is a fundamental process through which the body repairs itself following damage to the skin{\textquoteright}s integrity. This process is intricate and involves multiple biological mechanisms. The objective of this study is to assess the wound healing properties of β-chitosan and gelatin hydrogels. Twenty-five rats were divided into five groups to facilitate the evaluation of wound closure rates and histopathological changes. Upon analyzing the results, we noted a decrease in the initial surface area of all wounds examined. The extent of contraction varied depending on the type of hydrogel used. By day 14, the contraction was most significant in the hydrogel (ch + gel) group (97.30\%), followed closely by β-chitosan (96.72\%) and gelatin (96.63\%), as well as the cicatryl-bio treatment (92.76\%).

}, keywords = {Gelatin, Hydrogel, Os, Sepia Officinalis, Skin, Wound Healing, β Chitosan}, doi = {10.5530/pj.2025.17.31}, author = {Amina DOUBBI BOUNOUA and Mokhtaria Yasmina BOUFADI and Karima BOUGUEROUA and Soumia KEDDARI} } @article {2245, title = {Wound Healing Activity of an Essential Oil-Based Cream of Origanum vulgare L. on Mice}, journal = {Pharmacognosy Journal}, volume = {16}, year = {2024}, month = {April 2024}, pages = {292-295}, type = {Original Article}, chapter = {292}, abstract = {

Background and Aim: The objective was to evaluate the effect of a cream based on the essential oil of Origanum vulgare on skin lesions induced in Mus musculus Balb/c. Materials and Methods: The experimental animals were divided into four groups of 6 specimens each, in which skin lesions of approximately 1 cm in diameter were induced. Group I (Control) received no treatment, Group II (0.1\% Origanum vulgare cream), Group III (0.5\% Origanum vulgare cream), and Group IV (1\% Origanum vulgare cream) received treatment for eight days. Skin lesions were measured on days 4 and 7. At the end of treatment, they were euthanized using sodium pentobarbital 60 m/kg v.ip. Skin samples were obtained and preserved in 10\% formalin for histopathological analysis. Results: When measuring the size of the skin lesions induced in the study groups, it was observed that in the control group, the decrease in the length of the lesions occurred on the fifth day; in group II, III, and IV, the lesions length decrease occurs on the second day. At the end of the experience, the measurements of the lesions were much smaller for the III and IV groups (0.33 and 0.41, respectively) compared to the control group (0.40 cm). On day seven, statistically significant difference was found on skin lesion measure between Group IV and the Control, with a significance level of p\<0.05. Conclusion: It is concluded that the 1\% Origanum vulgare essential oil-based cream has a healing effect on dermal lesions induced in Mus musculus Balb/c.

}, keywords = {Cream, Essential oil, Origanum vulgare, Skin, Wound Healing}, doi = {10.5530/pj.2024.16.43}, author = {Laurente-Pachamango Katherine G and Cruzado-Razco Jos{\'e} L and Silva-Correa Carmen R and Villarreal-La Torre V{\'\i}ctor E and Sag{\'a}stegui-Guarniz William Antonio and Gamarra-S{\'a}nchez C{\'e}sar D and Ricardo M Gomez-Arce and Deivy Y Dionicio-Rosado and Julio A. Casta{\~n}eda-Carranza and Calder{\'o}n-Pe{\~n}a Abhel A and Aspajo-Villalaz Cinthya L and Ch{\'a}vez- Flores Juana E} } @article {1242, title = {Wound Healing Activity of an Ointment from Solanum tuberosum L. "Tumbay Yellow Potato" on Mus musculus Balb/c}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {September 2020}, pages = {1268-1275}, type = {Original Article}, chapter = {1268}, abstract = {

Background: Solanum tuberosum L. is an Andean tuber that is mainly characterized by its antioxidant properties. Objective: To evaluate the healing activity of an S. tuberosum-based ointment on wounds induced in mice. Material and methods: Ethanolic extracts of peel and pulp of tubers of S. tuberosum "Tumbay yellow potato" were prepared, which were incorporated into 1\% and 2\% ointment formulations. Mus musculus Balb/c with induced wound were distributed in the following working groups: Group I (Negative Control), Group II (Positive Control: Neomycin, Polymyxin B and Bacitracin Ointment) and Groups III and IV (Ointment at 1 \% and 2\% of S. tuberosum extract, respectively), daily administration of topical treatments were carried out for 07 days. Wound closure was determined during the experimentation time, then euthanized with sodium pentobarbital 60 mg/kg b.w. (i.p.) to obtain skin samples for histopathological analysis. Results: Groups III and IV showed that better evidence of wound closure and scarring in the histopathological analysis, the greatest effect being in Group IV. Conclusions: S. tuberosum ointments show healing activity in induced wounds in mice, the most effective treatment being the 2\% ointment formulation.

}, keywords = {Histology, Skin, Solanum tuberosum, Wound Healing, Yellow potato}, doi = {10.5530/pj.2020.12.175}, author = {Galy P Rosas-Cruz and Carmen R Silva-Correa and Abhel A Calder{\'o}n-Pe{\~n}a and V{\'\i}ctor E Villarreal-La Torre and Cinthya L Aspajo-Villalaz and Jos{\'e} L. Cruzado-Razco and Jorge Del Rosario-Ch{\'a}varri and Juan C Rodr{\'\i}guez-Soto and Orlando E Pretel-Sevillano and William Antonio Sag{\'a}stegui-Guarniz and Anabel D Gonz{\'a}lez-Siccha} }