@article {1212, title = {The Effect of Lentinus squarrosulus, (Mont.) Consumption on the Treatment of Gastritis in Male Wistar Rats}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {August 2020}, pages = {1093-1096}, type = {Research Article}, chapter = {1093}, abstract = {

Introduction: Gastritis or /and gastric ulcers are one of the most common symptoms which occur in a large amount of the population. It results in a very high amount of medication expense. This study investigated the prevention and treatment of gastritis or /and gastric ulcer actions using white log mushroom (Lentinus squarrosulus, (Mont.). Methods: White wistar rats were induced with 100 \% absolute alcohol to be effective for gastritis and /or ulceration within rats. The gastric lesions of white wistar rats were investigated and calculated the lesions of stomach areas under microscopic method. The results were calculated and a comparative study among white wistar rats. Ulcer prevention and ulcer healing properties were administrated though a dose of 250 mg/kg of L. squarrosulus extract and L. squarrosulus compared with 50 mg/kg of Ranetidine. Results: It was found that Lentinus squarrosulus, (Mont.) consisted of Beta-glucan was the active ingredient creating a healing effect. It showed a result of 100\% healing effect in gastritis and/or ulcers in which it had similar healing effects between extracted solutions of white log mushroom (250 mg/kg body wt.) The healing activity also showed the equivalent effect compared to Ranetidine 150mg. Conclusions: Extracted solution of white log mushroom showed prevention and treatment efficacy in gastritis and/ or ulcer are equivalent to Ranetidine 150 mg. A similar dose of 250 mg/kg of L. squarrosulus extract and L. squarrosulus snack can prevent and heal ulcers and is more effective than Ranetidine.

}, keywords = {Beta glucan, L. squarrosulus, Ranetidine 150 mg, Ulcer healing, Ulcer prevention}, doi = {10.5530/pj.2020.12.154}, author = {Buavaroon Srichaikul} }