@article {1193, title = {Capsaicin Bioactive in Cabai (Capsicum Annum L.) as Anticancer Through Inhibition of over Ekspresi Protein Target RAC-alpha serine/threonine-protein kinase (AKT1) and Mitogen-activated protein kinase 1 (MAPK1) on Hepatocyt Cell Mice (mus musculus)}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {June 2020}, pages = {911-915}, type = {Research Article}, chapter = {911}, abstract = {

Capsaicin is a secondary metabolite of the Chilean plant. In the pharmaceutical field in addition to relieving pain or pain, capsaicin is also known to have anticancer activity because it inhibits certain oncogenic proteins. Screening of components in Capsicum Annum L. against the target proteins AKT1 and MAPK1 is needed as an initial stage of drug discovery. Further screening of Capsaicin compounds for oncogenic proteins produced in Hepatocellular carcinoma (HCC) pathogenesis signaling. In silico data that have been obtained, Capsaicin in chili (Capsicum Annum L.) has a high affinity for MAPK1 and AKT1 receptor/protein targets with energy and potential activity score (Pa) 0.690 for preneoplastic treatment, 0.590 for apoptotic agonists, and 0.366 for antineoplastic activity. Statistical data using Kruskal Wallis obtained information that Capsaicin can inhibit the expression of AKT 1 and MAPK 1 on mice hepatocyte cells induced by AFB1 in vivo administration, therefore it can be a candidate for anticancer drugs.

}, keywords = {AKT1, Anticancer, Capsaicin, Hepatocellular carcinoma (HCC), MAPK1}, doi = {10.5530/pj.2020.12.129}, author = {Mohammad Sukmanadi and Sri Agus Sudjarwo and Mustofa Helmi Effendi and Pudji Srianto and Aulanni{\textquoteright}am and Rr Sri Pantja Madyawati and Mirni Lamid and Hani Plumeriastuti} } @article {1194, title = {Molecular Mechanism of Capsaicin from (Capsicum Annuum L.) on Expression of MAPK1 and AKT1 Protein as Candidate of Anticancer Drugs: In silico Study}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {June 2020}, pages = {916-919}, type = {Research Article}, chapter = {916}, abstract = {

One of the most important compounds in Capsicum annuum L. is capsaicin, capsaicin is a secondary metabolite of the Capsicum Annuum L. plant. In the pharmaceutical field in addition to relieving pain or pain, capsaicin is also known to have anticancer activity because it inhibits certain oncogenic proteins. Further screening of the capsaicin compound against the oncogenic protein produced in the HCC pathogenesis signaling is needed. Screening components in Capsicum annuum L. against MAPK1 and AKT1 target proteins is the initial stage of drug discovery. MAPK1 and AKT1 protein bundles and capsaicin ligand bundles that were prepared previously in Autodock 4.0 were molecular dockings (molecular docking). After molecular docking, it was found that capsaicin binds to MAPK1 / ERK with the free energy of Gibbs of -5.5 Kcal/mol and AKT1 of -6.7 Kcal/mol. The free energy of Gibbs is so negative that it is ensured that the reaction will take place spontaneously and lead to high affinity. The data that has been obtained, capsaicin in Capsicum annuum L. has a high affinity for MAPK1 and AKT1 receptor/protein targets with the binding energy of -5.5 Kcal/mol and -6.7 Kcal/ mol and Potential Activity Score (Pa ) equal to 0,690 for preneoplastic treatment, 0.590 for apoptosis agonist, and 0.366 for antineoplastic activity and accordingly become candidates for anticancer drugs.

}, keywords = {AKT1, Anticancer, Capsaicin, Capsicum annuum L., MAPK1}, doi = {10.5530/pj.2020.12.130}, author = {Mohammad Sukmanadi and Sri Agus Sudjarwo and Mustofa Helmi Effendi} }