@article {2602, title = {Integrating Ancient Therapeutics into Nutraceutical Oral Films for Alzheimer{\textquoteright}s Neuroprotection}, journal = {Pharmacognosy Journal}, volume = {18}, year = {2026}, month = {June 2026}, pages = {120-128}, type = {Original Article}, chapter = {120}, abstract = {

Background: There are many popular neuroprotective medicinal plants mentioned in Indian traditional medicine systems which need to made available to Alzheimer{\textquoteright}s patients in suitable dosage form. Objectives: Herbal nutraceutical in the form of oral fast dissolving film (OFDF) containing bioactive enriched fractions of traditionally well-known Indian nootropic plants will enhance neuroprotective efficacy and quality of life of Alzheimer{\textquoteright}s patients. Materials and Methods: The standardized extracts of Centella and Bacopa are prepared and formulated into oral films which further evaluated for pharmaceutical parameters, stability, safety and behavioural animal studies. Results and Conclusion: The modernised dosage form of traditional medicines in the form of oral films found to reduce dosage frequency due to enhanced bioavailability of bioactive enriched herbal extracts and is easy for administration to Alzheimer{\textquoteright}s patients. Behavioural animal studies exhibited promising multitargeted neurocognitive efficacy of developed oral films.

}, keywords = {Alzheimer{\textquoteright}s disease, Bacopa monnieri, Convolvulus pluricaulis, Dementia, neurocognitive efficacy, Withania somnifera}, doi = {10.5530/pj.2026.18.125}, author = {Sharada L. Deore and Anjali A kide and Bhushan A. Baviskar and Bhavana A. Shende} } @article {1356, title = {Learning and Memory Enhancing Activity of Polyherbal Formulation on Streptozotocin Induced Memory Impairment in Rats via Reducing Mitochondria{\textendash}Targeted Cytochrome}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {January 2021}, pages = {230-240}, type = {Research Article}, chapter = {230}, abstract = {

Introduction: Neurodegenerative diseases and/or brain injury may occur due to mild to severe memory disorders in which Alzheimer{\textquoteright}s disease (AD) is defined as degradation of neurons and there is no effective therapy or cure for the disease. The intention behind this study was to determine memory enhancing effect of an Ayurvedic polyherbal formulation (PHF) in Streptozotocin-induced memory deficit experimental animal models. Methods: Polyherbal formulation (PHF) was a suspension of three plant extracts i.e. Alpinia galanga, Glycerrhiza glabra and Convolvulus pluricaulis along with other excipients. Different behavioral animal models like Social recognition test (SRT), Morris water maze (MWM) test, Pole climbing test (PCT) and Elevated plus maze (EPM) test were used to evaluate efficacy of Polyherbal formulation (PHF) in learning and memory process of animals. Gene expression was performed by RT-PCR and western blot. Results: Results indicated that time of social recognition during trial 2 (SIT2) was reduced significantly (P\<0.01) due to PHF administration. In MWM test, treatment with PHF significantly (P\<0.01) reduced [F (4, 20) = 6.9] latency to reach hidden platform from session 3. Similarly, PHF was also found effective in pole climbing test and EPM test. RT-PCR results showed p53 regulates the Bcl-2 family proteins its expression in the given experiment was appreciably reduced in PHF (200mg/kg). NR1, NR2B and GAP-43 proteins leads to reduction of brain cell damage. Conclusion: Thus, PHF may be an effective formulation for learning and memory process against STZ-induced memory impairment.

}, keywords = {Alpinia galanga, Convolvulus pluricaulis, Elevated Plus Maze, Glycerrhiza glabra, Pole climbing test, Social recognition test}, doi = {10.5530/pj.2021.13.33}, author = {Deepa Shukla and Sajal Srivastava and Talha Jawaid} } @article {1149, title = {Memory Enhancing Efficacy of an Ayurvedic Polyherbal Formulation on Scopolamine-Induced Memory Deficit Experimental Models}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {May 2020}, pages = {589-597 }, type = {Research Article}, chapter = {589 }, abstract = {

The present study was performed to determine the efficacy of an ayurvedic polyherbal formulation (PHF) in the learning and memory process of animal models. The prepared PHF was a suspension of three plant extracts i.e. Alpinia galanga (AG), Glycyrrhiza glabra (GG) and Convolvulus pluricaulis (CP) along with other excipients. Learning and memory assessment of PHF was performed using different behavioral models in scopolamine-induced memory impairment animals. Biochemical estimation was performed to determine the enzymatic level of MDA, GSH and AChE level in rats. Results indicated that the time of social investigation trial 2 (SIT2) was reduced significantly compared to SIT1 due to the treatment of PHF. In the water maze test, plant extracts significantly decreased the latency time in the 4th and 5th sessions comparing to session 1. Administration of AG, CP, GG, and PHF caused amelioration of scopolamine-induced memory impairment in the MWM test. The extracts and PHF were also effective in reducing latency time in the pole climbing test. Biochemical parameters exhibited a reduction in MDA and AChE levels with an increase in GSH level after treatment with extracts and PHF. It can be concluded from the study that PHF is an effective formulation for learning and memory processes against scopolamine-induced memory impairment. Further, the isolation of active constituents is desired from different plant extracts.

}, keywords = {Alpinia galanga, Convolvulus pluricaulis, Glycyrrhiza glabra, Latency time, Pole climbing test, Social recognition test}, doi = {10.5530/pj.2020.12.88}, author = {Deepa Shukla and Sajal Srivastava and Talha Jawaid} }