@article {1097,
	title = {Effects of Beta-Carboline Alkaloids of Peganum Harmala on Induced Rat Ileum Contractions},
	journal = {Pharmacognosy Journal},
	volume = {12},
	year = {2020},
	month = {March 2020},
	pages = {260-265},
	type = {Original Article},
	chapter = {260},
	abstract = {<p class="rtejustify"><em>Peganum harmala </em>L., Zygophyllaceae popularly known as Wild Syrian rue, a well-known plant in folk medicine for many pharmacological uses including antispasmodic activity. Chemical composition of the plant showed that the most important constituents of this plant are betacarboline alkaloids such as harmalol, harmaline, and harmine. In this work, we aimed to evaluate the effects of these three major harmala alkaloids on induced rat ileum contractions, induced by acetylcholine, BaCl<sub>2</sub> and KCl. Of these three harmala alkaloids, harmalol and harmaline produced a concentration-dependent spasmolytic activity, which was found to be reversible (i.e. disappeared after tissue wash-up. Both alkaloids inhibited acetylcholine and KCl-induced ileum contractions but BaCl<sub>2</sub> -induced contractions were only inhibited by harmalol but not harmaline. Harmine did not show any inhibitory activity.</p>
},
	keywords = {Harmaline, Harmalol, Harmine, Ileum, Peganum Hermala L, Rat, Spasmolytic, β-Carbolines alkaloids},
	doi = {10.5530/pj.2020.12.40},
	author = {Amjad T Shatarat and Sawsan Abuhamdah and Eman Alefishat and Mohamed K Al-Essa and Rima Altaweel R and Faisal Mohammed and Darwish Badran and Hanan Jafar}
}
