@article {1077, title = {Activity of Kincung Flowers (Etlingera Elatior (Jack) R.M.Sm.) on Total Leukocytes and Percentage of Leukocytes in Allergic Male White Mice}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {February 2020}, pages = {44-51}, type = {Original Article}, chapter = {44}, abstract = {

Introduction: Kincung Flower (Etlingera elatior (Jack) R.M.Sm.) is a native herbal plant in Southeast Asia that traditionally used to many diseases, especially in Indonesia. Aim: This study was conducted to determine the activity of kincung (Etlingera elatior (Jack) R.M.Sm.) on the total number of leukocytes and differential leukocyte cells in allergic mice. Material and Methods: The semi-solid extract of Kincung flower (Etlingera elatior (Jack) R.M.Sm.) was made by the maceration method using 70\% ethanol solvent. The animals used were 20 male white mice that have allergies of skin that treated with 20\% albumen antigens given on the first day 0.2 mL/20 g intraperitoneally, then on the seventh day are given antigens with the same dose subcutaneously. Allergic mice indicated by redness at the injection site. It divided into four groups: the negative control group and three dose groups (100; 300; and 1000 mg/kg). On the seventh day after administration of the extract, observed the value of total leukocytes and differential leukocyte cells in mice. Results: The results after administration of extracts in 3 dose groups (100; 300; and 1000 mg / kg) and the negative control group showed sequentially the total number of leukocytes was: 3.95; 4.73; 6.01; and 3.6 x103/μL and the percentage of leukocytes consisting of lymphocytes: 67.6\%; 62.0\%; 56.8\% and 70.0\%, neutrophils: 22.4\%; 29.2\%; 36.8\% and 20.0\%, eosinophils: 6.4\%; 5.8\%, 4.2\% and 6.6\%, monocytes: 3.6\%; 3.0\%, 2.2\% and 3.4\%, and basophils: 1.8\%; 1.4; 0.8\% and 2.0\%. It concluded that kincung flowers could increase total leukocytes significantly (p\<0.05), decrease lymphocytes, eosinophils, basophils significantly (p\<0.05), increase neutrophils significantly (p\<0.05), and reduce monocytes insignificantly (p\>0.05). Conclusion: Kincung flowers (Etlingera Elatior (Jack) R.M.Sm.) can be used as an immunomodulator and decreasing the percentage of basophil cells, and eosinophils can used as an anti-allergic drug.

}, keywords = {Allergies, Etlingera elatior (Jack) R.M.Sm, Kincung Flower, Leukocyte Percentage, Mice, Total Leukocytes}, doi = {10.5530/pj.2020.12.8}, author = {Yufri Aldi and Elidahanum Husni and Relin Yesika} } @article {1164, title = {The Extract of Kincung Flower (Etlingera elatior (Jack) R.M.Sm.) Activity to Decrease IL-4 and IgE Levels in Type I Hypersensitivity White Male Mice}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {June 2020}, pages = {682-686}, type = {Original Article}, chapter = {682}, abstract = {

Introduction: Kincung Flower (Etlingera elatior (Jack) R.M.Sm.) is a herbal plant which contains many secondary metabolites. It showed to suppress allergic reactions by inhibiting mast cell degranulation, active cutaneous anaphylaxis and decreasing the number of basophils and eosinophils. Aim: The study conducted to determine the decreased IL-4 and IgE level of type I hypersensitivity male white mice using kincung flowers extract. Materials and Methods: The maceration method used to make ethanol extract of Kincung flower (Etlingera elatior (Jack) R.M.Sm.). The research used 25 allergic male white mice, which made by injected 20\% albumen that given on the first day 0.2 mL/20 g intraperitoneally. On the seventh day are given albumen with the same dose subcutaneously. The characteristic of the allergic mice is the redness at the injection site. It divided into five groups: the negative control group, the positive control group and three dose groups (100; 300; and 1000 mg/kg). After mice given extract for seven days, then measured IgE and IL-4 levels in the serum of mice. Results: The results after three dose groups (100; 300; and 1000 mg/kg) given, the negative and positive control group showed sequentially the IL-4 level was: 33.024; 27.933; 25.192; 23.130 and 41.538 ng/ mL. And IgE level in serum was 0.944; 0.629; 0.210; and 1,597 μg/ mL. Conclusion: It concluded that kincung flowers decreased IL-4 and IgE level significantly (p\<0.05). So it could use as an anti-allergic drug.

}, keywords = {Allergies, Etlingera elatior (Jack) R.M.Sm, IgE, IL-4, Kincung Flower, Mice}, doi = {10.5530/pj.2020.12.100}, author = {Elidahanum Husni and Relin Yesika and Yufri Aldi} }