@article {2598, title = {The Effectiveness of Enteral Administration of Binahong Leaf Extract (Anredera cordifolia (Tenore) Steenis) on Blood Glucose Levels, MDA, and NGF in Wistar Rats with Diabetic Neuropathy Model}, journal = {Pharmacognosy Journal}, volume = {18}, year = {2026}, month = {June 2026}, pages = {107-112}, type = {Original Article}, chapter = {107}, abstract = {

Background: Chronic hyperglycemia causes oxidative stress in the peripheral nervous system, which leads to the development of diabetic neuropathy. Free radicals initiate lipid peroxidation of membranes and produce malondialdehyde (MDA). Reduced Nerve Growth Factor (NGF) in diabetes indicates significant neuronal abnormalities. Binahong (Anredera cordifolia (Ten.) Steenis) belongs to the Basellaceae family and possesses therapeutic effects, making it a promising herbal remedy for the development of treatments for diabetic neuropathy. Objective: To determine the effectiveness of binahong leaf extract (Anredera cordifolia (Tenore) Steenis) in lowering blood sugar and MDA levels and increasing NGF in Wistar rats with diabetic neuropathy. Methods: This study was an experimental study using rats with a randomized control trial with a post-test control only design. The study population consisted of 36 Wistar rats divided into 6 groups randomly, which were then induced with diabetic neuropathy via streptozotocin injection at 65 mg/kg. Complete data collection was conducted, followed by blood glucose levels, MDA, and NGF measurements, and data analysis. Results: There were significant differences (p\<0.05) in blood glucose levels, MDA, and NGF between the normal group, the 50 mg/kg binahong leaf extract group, the 100 mg/ kg radish extract group, and the 200 mg/kg group compared to the negative control group. This indicates that binahong leaf extract, starting at a dose of 50 mg/kg, can reduce blood glucose levels and MDA while increasing NGF. Conclusion: Binahong leaf extract (Anredera cordifolia (Tenore) Steenis) is effective in lowering blood glucose levels and MDA levels while increasing NGF in a rat model of diabetic neuropathy.

}, keywords = {Anredera cordifolia, blood glucose levels, Diabetic neuropathy, Malondialdehyde, Nerve Growth Factor, Wistar Rats}, doi = {10.5530/pj.2026.18.123}, author = {Ana Fresia and Gusbakti Rusip and Ade Indra Mukti and Ali Napiah Nasution} } @article {1349, title = {The Antioxidant Effects of the Ethanolic Extract of Binahong Leaves Unilateral Ureteral Obstruction Rat Model}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {January 2021}, pages = {185-188}, type = {Research Article}, chapter = {185}, abstract = {

Background: Chronic kidney injury produced free radicals. In a previous study, the ethanolic extract of binahong leaves (Anredera cordifolia (Ten.) Steenis) has a flavonoid content, quercetin, a protective free radical effect. This study aims to determine the impact of binahong leaves against chronic kidney damage in Sprague Dawley rats. Results: To this end, we developed a chronic kidney injury animal model by Unilateral Ureteral Obstruction (UUO) method. We randomly divided rats into six groups. Group I is the Sham group; Group II is the negative control group; Group III is the positive control group (losartan 1.18 mg/kg BW); Group IV is Dose I of binahong leaves extract 75 mg/kg BW); Group V is Dose II binahong leaves extract 150 mg/kg BW); Group VI is Dose III binahong leaves extract 300 mg/kg BW). We administered losartan and binahong extracts on day 14 after UUO treatment. The plasma was examined for the superoxide dismutase (SOD) enzyme activity, catalase enzyme activity, and malondialdehyde (MDA). All statistical analyzes were processed using the Statistical Program of Social Sciences (SPSS) software for Windows, version 16. The measured values of the parameters were expressed in mean {\textpm} SD. The difference test between groups was evaluated by ANOVA (Analysis of Variance) followed by LSD (Least Significant Difference) with a degree of significance (p) \<0.05 if the data distribution was normal and homogeneous. If the distribution of data is not normal and not homogeneous use non-parametric Kruskal Wallis analysis. Results: The results showed that UUO produced high MDA levels, whereas SOD activity and catalase activity were decreased compared with the Sham group. Administration of binahong extracts could reduce the MDA amount and increased the SOD and catalase activity. Conclusion: Binahong leaves extracts showed antioxidant activity to prevent kidney injury in UUO model rats.

}, keywords = {Anredera cordifolia, Binahong, Chronic kidney injury, Unilateral Ureteral Obstruction}, doi = {10.5530/pj.2021.13.26}, author = {Anton Bahtiar and Putri Sagita Utami and Melati Raisa Noor} } @article {1051, title = {Impact of Solvent on the Characteristics of Standardized Binahong Leaf (Anredera cordifolia (Ten.) Steenis)}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {November 2019}, pages = {1463-1470}, type = {Original Article}, chapter = {1463}, abstract = {

Background: Binahong is a plant that has the potential to be used as a traditional herbal medicine in Indonesia, and has several kinds of classes of compounds, one of them is a flavonoids glycosides (vitexin). Previous research reported that binahong leaves have pharmacological activities as antihyperglycemic, antihyperlipidemic, antibacterial, and others. A traditional plant that has proven efficacious needs to be standardized to ensure the quality and its safety. Objective: This study aimed to characteristics of binahong leaves simplicia obtained from Bogor, West Java. Materials and Methods: The crude extract was obtained by the maceration method using 40\%, 70\%, and 96\% ethanol solvent. The selected extract then standardized, which includes macroscopic and microscopic observations and sets the standard parameter values binahong leaf extract. Parameters LCMS to identify active compounds semiquantitatively. Results: The yield of binahong ethanol extract from 40\%, 70\%, 96\% showed a value of 10.9\%, 11.4\%, and 12.32\%, respectively. From these results, 96\% ethanol extract has proceeded for standardization. Macroscopic observation results showed that binahong leaves simplicia has a fine and notched form with 5-10 cm long and 3-7 cm diameter. The microscopic binahong leaves contain palisade tissue, parenchymal tissue, chlorophyll grains, rosette Caoxalate crystals, and spiral type. Phytochemical screening of binahong leaves showed the presence of alkaloids, flavonoids, saponins, tannins, steroids, and phenolic compounds.The standardization of binahong leaves ethanol extract down showed a levels of ethanol-soluble extract\> 14.8\%, water-soluble extract content \> 13.5\%, drying \< 10\%, water content \< 8.9\%, total ash content \< 7.2\%. LCMS profiles showed that ethanolic extract 40\%, 70\%, and 96\% all contained vitexin at retention time 5.02 minutes, and m/z values 433.1111. Conclusion: 96\% ethanolic extract of binahong leaves contains vitexin with pharmacognostic parameters carried out following the standards listed in the Indonesian herb pharmacopeia.

}, keywords = {Anredera cordifolia, Extract, LCMS, Simplicia, standardization}, doi = {10.5530/pj.2019.11.226}, author = {Dwitiyanti and Yahdiana Harahap and Berna Elya and Anton Bahtiar} }