@article {1420, title = {Both Ethanol and Ethyl Acetate Curcuma Zedoaraia Extract was Capable of Inducing Cells Death in T47D Cell Line Culture}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {May 2021}, pages = {737-743}, type = {Research Article}, chapter = {737}, abstract = {

Introduction: Curcuma zedoaria (CZ) has been proven capable of inducing apoptosis in cells cancer. CZ extraction can be performed by ethanol and acetyl acetate as solvent. However, which one of these extracts is superior remains unclear. Objective: This study aimed to investigate the difference potential effect of ethanol and acetyl CZ extract on apoptosis of T47D cell line. Methods: In this study 21 wells were assign into seven groups: control group (T47D); treatment groups consisting of group of ethanol CZ extract 46 (EtZ-46); group of ethanol CZ extract 23 (EtZ-23); group of ethanol CZ extract 11 (EtZ-11); and group of ethyl acetate CZ extract 111 (AcZ-111); group of ethyl acetate CZ extract 55 (AcZ-55); and group of ethyl acetate CZ extract 27 (AcZ-27). In T47D group only loaded with T47D cell line; in treatment groups aside from loaded with T47D cell line culture, also treated with ethanol or acetyl acetate CZ extract respectively. Concentration of T47D cell was 5 x 104 T47D cells line in 100 μl suspension loaded on each well of 21 wells and kept in CO2 incubator overnight. The apoptosis cells were measured after 48 hours post CZ treatment. Results: Post Hoc analysis indicated that the number of apoptosis cells in AcZ-111 was significant higher compared to that of other groups, p\<0.05. Conclusion: Acetyl acetate CZ extract treatment with dose 111 μg was capable of inducing apoptosis in T47D cell line superior than that of other groups including ethanol CZ extract.

}, keywords = {Acetyl acetate, Apoptosis, Curcuma zedoaria, Ethanol, Necrosis, T47D cell line}, doi = {10.5530/pj.2021.13.94}, author = {Titiek Sumarawati and Chodidjah and Taufiqurrachman Nasihun} } @article {1041, title = {The Medicinal Plants Used in Anjir Pulang Pisau, Central Kalimantan-Indonesia}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {November 2019}, pages = {1572-1579}, type = {Research Article}, chapter = {1572}, abstract = {

Background: The use of medicinal plants in Anjir Pulang Pisau Village has been carried out for a long time through knowledge that is passed down through generations to family members. But there is no documentation of local knowledge about medicinal plants. Objective: This study was aimed to investigate the use of medicinal plants in Anjir Pulang Pisau Village, Central Kalimantan-Indonesia. Methods: The data were collected through individual interviews using semi{\textemdash}structured interviews. Information regarding the local names of the plant, medicinal uses, parts used, methods of preparation, and administration route were documented. Results: A total of 28 medicinal plants were identified. The family Anacardiaceae, Lamicaeae, Poaceae, and Myrtaceae had the highest proportion of medicinal plants used (7\% each). The most frequently utilized medicinal plant parts were roots (47\%). The plant species used to treat the high percentage of disease was Curcuma zedoaria (Christm.) Roscoe. (16\%). In terms of frequency of medicinal plant uses, the highest percentage of plant species (21\%) was used to treat wound. Majority of the plant remedies in this study were prepared by decoction (40\%), and most medicinal plant preparations were taken orally (75\%). Conclusion: Further research is needed to identify unidentified family and plant species. Pharmacognostical and pharmacological studies are also needed for the identification of chemical compounds and proving the efficacy of medicinal plants used by local people.

}, keywords = {Curcuma zedoaria, Ethnomedicine, Kahayan Hilir, Pulang Pisau, Traditional Knowledge}, doi = {10.5530/pj.2019.11.240}, author = {Susi Novaryatiin and Indah Indah} }