@article {2230, title = {Effect of Plasma Treatment on Tensile Bond Strength of (5) Yttrium Zirconia Coping Fixed on Titanium Implant Abutment}, journal = {Pharmacognosy Journal}, volume = {16}, year = {2024}, month = {February 2024}, pages = {205-210}, type = {Research Article}, chapter = {204}, abstract = {

Objective: The goal of this research is to investigate the effect of plasma surface treatment on retentive strength (RS) between the (5)Yttrium Zirconia coping and the titanium implant abutment (Dentium system) using self-adhesive resin cement. Methods: forty standard titanium implant abutments of 5.5 mm height and 4.5 mm in diameter were screwed with implant laboratory analogs embedded vertically in autopolymerizing acrylic resin blocks, forty Zirconia copings with a hole on the occlusal surface were fabricated using CAD/CAM system. Samples were divided into four groups (n 10 for each group); Group (1) no plasma surface treatment for implant abutment and coping (act as control). Group (2) plasma surface treatment for implant abutment only. Group (3) plasma surface treatment for coping only. Group (4)plasma surface treatment for implant abutment and coping. Coping of all groups were cemented with implant abutment by Allcem dual cure resin cement. All cemented samples were (5000) cycles of thermocycling process and then tensile bond strength evaluated by Universal testing machine, Following the tensile bond strength test, each debonded surface was examined by stereomicroscope at a 20x magnification. The one-way analysis of variance and Duncan test were used to statistically examine the experimental results. Results: Plasma surface treatment had observed effect that increase tensile bond strength between titanium implant abutment and (5) yttrium Zirconia coping, plasma surface treatment for abutment and coping (Group 4) was the highest value of tensile strength followed by abutment plasma surface treatment (Group 2), while lowest value of tensile bond strength in control group (Group 1) and coping plasma surface treatment (Group 3). Conclusion: Plasma surface treatment increase tensile bond strength between implant abutment and zirconia coping. Plasma surface treatment for both abutment and coping provided higher tensile bond strength. Mode of failure was adhesive failure occurs in abutment surface.

}, keywords = {(5)Y Zirconia. Tensile bond strength, Plasma, Titanium abutment}, doi = {10.5530/pj.2024.16.29}, author = {Amani Abduljabar Altaie and Emad Farhan Alkhalidi} } @article {962, title = {A New LC/MS/MS Method for the Analysis of Phyllanthin in Rat Plasma and its Application on Comparative Bioavailability of Phyllanthin in Different Formulations after Oral Administration in Rats}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {September 2019}, pages = {968-975}, type = {Original Article}, chapter = {968}, abstract = {

Introduction: A simple, short UPLC/MS/MS method for quantitation of phyllanthin in rat plasma in less than 2 minutes have been developed and fully validated. The validated method was used to investigate the pharmacokinetic properties of phyllanthin in PA extract and phospholipid complex of PA extract in rat. Methods: The separation was carried out on Acquity C18 (50 x 2.1 mm; 1.7 μm), with a mobile phase of 10 mM aqueous amonium acetate and acetonitrile (10:90; v/v), at a flow rate of 0.2 mL/min. Felodipin was used as internal standard. Phyllanthin is extracted from a small volume of rat plasma (100 μl) by means of liquid-liquid extraction method with tert butyl methyl ether. Electrospray ionization (ESI) mass spectrometry was applied in positive mode at capillary voltage of 4000 V for both phyllanthin and IS, cone voltage of 24 V for phyllanthin and 20 V for IS, desolvation temperature of 360oC, cone gas flow of 25 L/h, collision energy of 12 V for phyllanthin and 10 V for IS. Multiple reaction monitoring (MRM) was used to monitor the transitions at m/z (Q1/Q3) 436.41/355.36 for phyllanthin and 384.20/352.18 for IS. Results: The linear calibration curve of phyllanthin was obtained over the concentration range of 0.5 {\textendash} 100 ng/mL. The intra- and inter-day precisions were less than 7.08 \% and the accuracies were within {\textpm} 7.55\%. The Cmax values of phyllanthin from two different preparations in rat plasma after oral administration of 2.0 mg/kg were 11.44 and 31.44 ng/ml, and the AUC values were 18.07 and 41.43 h.ng/ml, respectively. Conclusion: A simple, short UPLC/MS/MS method for quantitation of phyllanthin in rat plasma in less than 2 minutes have been developed and fully validated. The bioavailability of phyllanthin from the phospholipid complex of PA extract in rat plasma was significantly improved compared with that of raw PA extract after oral administration.

}, keywords = {LC-MS/MS, Pharmacokinetics, Phospholipid, Phyllanthin, Plasma, Quantitation}, doi = {10.5530/pj.2019.11.153}, author = {Nguyen Van Long and Chu Van Men and Anh Vu Tuan and Nguyen Van Manh and Thanh Chu Duc and Ha Bui Thi Thu and Hoang Van Luong and Le Bach Quang and Pham Gia Khanh} }