@article {1971, title = {Sun Protection Factor Activity of Jamblang Leaves Serum Extract (Syzygium cumini)}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {March 2023}, pages = {134-140}, type = {Research Article}, chapter = {134}, abstract = {

Background: The development of serum preparations containing natural ingredients for sun protection is growing rapidly. Jamblang (Syzygium cumini) leaves are rich in phenolic compounds that can inhibit free radicals causing premature aging. Therefore, this study aims to determine the potential of S. cumini serum extract as sun protection. Methods: The extract was prepared and included in the serum base. The formulations were evaluated for rheological, pH, dispersion coefficient, and stability examinations. Furthermore, Sun Protection Factor was tested using a UV-Vis spectrophotometer. Results: The test of phytochemical compounds showed the presence of alkaloids, flavonoids, polyphenols, tannins, saponins, quinones, monoterpenoids, sesquiterpenoids, triterpenoids, and steroids. The result also showed that all serum formulations met the predetermined requirements. Furthermore, the extract has protective activity against ultraviolet rays, which was indicated by the SPF value. The higher the dose of S. cumini extracts in the serum formulation, the higher the value obtained. Formulations 1, 2, and 3 have SPF of 9.35{\textpm}0.11, 13.26{\textpm}0.16, and 26.05{\textpm}0.31, respectively. This indicates that they all met the Indonesian National Standard, that a sun protection preparation must have a minimum protection factor of 4. Conclusion: S. cumini extract serum has the potential to be developed as a new sun protection agent against ultraviolet radiation. However, further studies are still needed to determine the mechanism of its constituent active compounds.

}, keywords = {Serum, Sun protection factor, Syzygium cumini, Ultraviolet.}, doi = {10.5530/pj.2023.15.18}, author = {Himyatul Hidayah and Surya Amal and Nia Yuniarsih and Farhamzah and Anggun Hari Kusumawati and Neni Sri Gunarti and Ermi Abriyani and Iin Lidia Putama Mursal and Adinda Khansa Sundara and Maulana Yusuf Alkandahri} } @article {1938, title = {The Serum Formulation of Hati Tanah Tuber Ethanol Extract from Central Kalimantan}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {January 2023}, pages = {978-982}, type = {Research Article }, chapter = {978}, abstract = {

Introduction: Lately, the use of natural cosmetics can have a good effect on the skin. One of them is traditional beauty treatments. The Serum is a preparation with low viscosity, because of its low viscosity serum is categorized as an emulsion preparation. From the results of research that has been carried out, ethanol extract of Hati Tanah tuber has great potential as an anti-acne because it can inhibit the growth of acne-causing bacteria such as Staphylococcus aureus, Staphylococcus epidermidis, Propionibacterium acnes. With the innovation of serum ethanol extract of Hati Tanah tuber, it can be an option for the community later in the treatment of acne. Methods: The formulation is made in 4 (four) formulas with different concentrations of the main ingredients used. Next is to weigh all the ingredients needed according to each formula. Then physical properties test performed. a) Organoleptic test; b) Homogeneity Test; c) pH test; d) Spreadability Test and e) Adhesion Test. Results: The organoleptic test was carried out directly by looking at the shape and color and smelling the serum preparation of the ethanol extract of Tanah Hari tubers. The test results show that at F0 (0\%) the color is clear, for F1 (0,5\%) it is quite pale pink, F2 (1\%) is bright pink and F3 (5\%) is dark red. For scent organoleptic, F0 indicates no scent, for F1 and F2 there is a distinctive scent from the Hati Tanah tuber which is slightly pungent, while F3 shows a pungent aroma typical of the Hati Tanah tuber. The resulting serum has a thick texture at F0 and F1, a watery texture at F2 and a thinner texture at F3. All of the formulas have met the physical test requirement of organoleptic properties, homogeneity, pH, and adhesion test. Conclusion: The simplicia of Hati Tanah tuber can be made into an innovative cosmetic preparation in the form of serum with a concentration of 0,5\%, 1\% and 5\%. From the results of testing the physical properties of the formulations, all of the formulas have met the physical test requirement of organoleptic properties, homogeneity, pH, and adhesion test.

}, keywords = {Formulation, Hati Tanah Tuber Ethanol Extract., Serum}, doi = {10.5530/pj.2022.14.199}, author = {Nurul Qamariah and Rezqi Handayani and Jessika Maretania} } @article {961, title = {Aloe Vera Peel Extract Administration Increased Antioxidant Enzyme Levels of Serum and Seminal Plasma in Type 2 Diabetic Rats}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {September 2019}, pages = {962-967}, type = {Original Article}, chapter = {962}, abstract = {

Background: Diabetes mellitus (DM) is considered as a complex metabolic disorder characterized by hyperglycemia. Aim: The present study aimed to evaluate the effect of Aloe vera peel extract on the antioxidant levels of serum and seminal plasma of type 2 diabetic rats. Materials and Methods: Male Wistar rat was injected by 65 mg/kg streptozotocin (STZ) combined with 230 mg/kg of Nicotinamide acid (NA) intraperitoneally. The rats were declared to have diabetic with fasting blood glucose level \> 200 mg/dl 72 hours after induction. Diabetic rat samples were divided into four groups, control group (diabetes without treatment) and three groups were treated by Aloe vera peel extracts orally: 100 mg (P.1), 200 mg (P.2), and 400 mg/kg body weight (P.3), respectively. Antioxidant levels of serum and seminal plasma, including superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) were examined after 28 days of treatment. Results: The levels of SOD, CAT, and GSH in the group receiving Aloe vera peel extract were statistically significant (p \<0.05) higher than the control. There were also significant differences between the dose variations group. Conclusion: Aloe vera peel extract can significantly increase antioxidant levels in serum and seminal plasma of type 2 diabetic mice.

}, keywords = {Aloe vera peel extract, Antioxidants, Diabetes, Seminal Plasma, Serum}, doi = {10.5530/pj.2019.11.152}, author = {Wulan Christijanti and Achmad Zulfa Juniarto and Lisyani B. Suromo} }