@article {1000, title = {Inhibitory Effects of Different Varieties of Sweet Potato (Ipomoea batatas L.) Tubers Extracts on Lipoxygenase Activity}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {October 2019}, pages = {1195-1198}, type = {Original Article}, chapter = {1195}, abstract = {

Background: Sweet potatoes (Ipomoea batatas L.) with purple, orange and white varieties can be differentiated by their skin and flesh tubers{\textquoteright} colors. Research on anti-inflammatory activity of this plant is still limited although has been used traditionally. Objective: This study aimed to determine IC50 value of sweet potato tubers extracts in inhibiting lipoxygenase activity. Methods: Dried tubers of sweet potato were macerated with ethanol 70\%. Each extracts were tested for soybean lipoxygenase inhibitory activity, phytochemical screening and total flavonoid contents. IC50 value and total flavonoid contents obtained from each extracts were analyzed statistically. Results: IC50 value of purple, orange and white sweet potato tubers extracts are 46.09, 52.12 and 63.69 μg/mL respectively. Each extracts contain alkaloids, flavonoids, saponins, tannins and glycosides. Total flavonoid contents in purple, orange and white sweet potato extracts are 8.45{\textpm}0.41; 7.57{\textpm}0.03; and 6.12{\textpm}0.14 mgQE/g extract respectively. Conclusion: Total flavonoid contents and IC50 values of each extracts are strongly correlated and inversely proportional with significance value of 0.026 and correlation value of -0.999 which indicate that the higher total flavonoid contents, the stronger inhibitory activity.

}, keywords = {Anti-inflammatory, Ipomoea batatas L, Lipoxygenase, Sweet potato tubers, Total flavonoid contents}, doi = {10.5530/pj.2019.11.185}, author = {Sendangratri and Rosita Handayani and Berna Elya} } @article {696, title = {Antioxidant Activities, Acute Toxicity and Chemical Profiling of Torch Ginger (Etlingera elatior Jack.) Inflorescent Extract}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {August 2018}, pages = {979-982}, type = {Original Article}, chapter = {979}, abstract = {

Aim/Background: The objectives of the study were to determine total phenolic contents, flavonoid contents, antioxidant activities and assess acute toxicity of torch ginger (Etlingera elatior Jack.) inflorescent hydroethanolic extract. Methods: The analysis of total phenolic contents, total flavonoid contents and antioxidant activities were analyzed spectrophotometrically using micro-titer plate reader. With regard to acute toxicity assessment, Wistar rats were fed with a single dose of torch-ginger either 1.0, 1.5 or 2.0 g extract/kg body weight in comparison with control group. Results: Total phenolic contents, flavonoid contents of the extract were 0.17\±0.02 mM gallic acid equivalent/g extract and 0.30\±0.01 mM quercetin equivalent/g extract, respectively. The antioxidant evaluation using DPPH radical scavenging assay, FRAP assay and ABTS radical scavenging assay were 0.14\±0.08 mg/ml (EC50), 0.13\±0.01 mmol Fe2+ equivalent/g extract and 0.30\±0.12 mM trolox equivalent/g extract, respectively. According to acute toxicity, no mortality or bizarre behavior had been observed throughout 14 days. Clinical chemistry including blood glucose, AST, ALT, BUN, creatinine, total cholesterol, triglyceride, HDL, LDL, total serum protein, albumin, globulin and total bilirubin were in normal ranges and comparable to the control (p\<0.05). In conclusion, phenolic compounds and flavonoids of torch-ginger could be measured and indicated the quality of the extract as well as antioxidant activities. Regarding acute toxicity assessment, the extract was safe for experimental animals up to 2.0 g extract/kg body weight. Conclusion: Torch-ginger extract exhibited high amounts of phenolic contents, flavonoid contents, antioxidant activities and was safe in animal model.

}, keywords = {Acute toxicity, Antioxidant Activities, Torch ginger, Total flavonoid contents, Total Phenolic Contents}, doi = {10.5530/pj.2018.5.166}, author = {Bunleu Sungthong and Buavaroon Srichaikul} }