@article {619, title = {Neuroprotective Activity of Sesbania grandifolara Seeds Extract Against Celecoxib Induced Amnesia in Mice}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {May 2018}, pages = {747-752}, type = {Original Article}, chapter = {747}, abstract = {

Background: Sesbania grandiflora are characterized by their high anti-oxidant properties. The degeneration of neurons in Alzheimer disease mainly occurs because of high production of free radicals. However, the impact of Sesbania grandiflora on cholinergic system and oxidative stress parameter has not been investigated. Aim: The present study was designed to evaluate the neuroprotective effect of ethanolic extract of Sesbania grandiflora seeds in mice. Material and method: The seeds of Sesbania grandiflora were powdered and subjected to successive extraction in Soxhlet apparatus. The different doses of ethanolic extract of Sesbania grandiflora seeds were evaluated for its neuroprotective activity against celecoxib induced amnesia in mice. Result and Conclusion: Phytochemical analysis of various extracts of Sesbania grandiflora revealed the presence of steroid, saponin, flavonoid, tannins and phenolic compounds. The ethanolic extract of Sesbania grandiflora significantly improves the memory of mice and reestablishes the amnesia induced by celecoxib. In addition to improvement in memory the extract treatment also decreases the activity of AchE and MDA and restore the antioxidant anzyme SOD, GSH and catalase in experimental animals. The results of our study showed that ethanolic extract of Sesbania grandiflora improve the cognition dysfunction in celecoxib treated mice through the modification in cholinergic system or by the blockage of oxidative stress and inhibition of AchE enzyme.

}, keywords = {Acetylcholine, Celecoxib, Free radical, Morris water maze, Sesbania grandiflora}, doi = {10.5530/pj.2018.4.125}, url = {http://fulltxt.org/article/663}, author = {Bhupesh Chander Semwal and Madhuri Verma and Yogesh Murti and Harlokesh Narayan Yadav} } @article {1438, title = {Hepatoprotective effect of Livplus- A polyherbal formulation}, journal = {Pharmacognosy Journal}, volume = {7}, year = {2015}, month = {9th June 2015}, pages = {4-4}, type = {Original Article}, chapter = {4}, abstract = {

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}, keywords = {Acetylcholine, Antitussive, Bronchoprotection, Citric acid, Cough, Cough variant asthma (CVA), Ethanolic extract of Woodfordia fruticosa (L.) Kurz (EEWF), Histamine.}, author = {Rajesh A Maheshwari, and Bhagyashree Pandya and R. Balaraman, Avinash K Seth and Yogesh Chand and Yadav and Vasa Siva Sankar} } @article {73, title = {Phytopharmacological evaluation of aerial parts of Woodfordia fruticosa (L.) Kurz in Cough Variant Asthma}, journal = {Pharmacognosy Journal}, volume = {7}, year = {2015}, month = {01/2015}, pages = {296-299}, type = {Original Article}, chapter = {296}, abstract = {

Background: Cough variant asthma (CVA) is characterized by prolonged non productive cough which responds to bronchodilator therapy. None of herbal drug is reported to possess pharmacological activity against CVA. Objective: To investigate the pharmacological potential of ethanolic extract of Woodfordia fruticosa (L.) Kurz (EEWF) against CVA as well as to develop an efficient screening model for CVA. Material and Method: Anti-tussive effect of EEWF was evaluated against nebulized aqueous solution of 0.1 g/ml of citric acid to determine the cough response. EEWF potential was finally accessed against aerosolic mixture of 0.3 g/ml of citric acid mixed with 0.1\% histamine and 2\% acetylcholine chloride to evaluate the convulsive latency, percentage protection and cough frequency against CVA. Results: EEWF at aerosolic dose of 6\% w/v exhibit decrease in of the average coughs frequency (4.83 \± 0.30) which is quite significant effect as compared to standard drug codeine. EEWF against aerosol induced CVA was found to exhibit a significant bronchoprotection of 41.75\% and decreases number of coughs (7.16 \± 0.47) at 200 mg/kg as compared to control (14.16 \± 0.60). Conclusion: EEWF at 200 mg/kg dose exhibited bronchoprotective and anti-tussive effects against aerosol induced CVA.

}, keywords = {Acetylcholine, Anti-tussive, Bronchoprotection, Citric acid, Cough, Cough variant asthma (CVA), Ethanolic extract of Woodfordia fruticosa (L.) Kurz (EEWF), Histamine.}, doi = {10.5530/pj.2015.5.8}, author = {Amit Kumar Srivastava and Srivastava Abhinav Siddharth and Nagar Hemant and Srivastava Rajnish and Deepa and Shukla Gaurav} } @article {1444, title = {Phytopharmacological evaluation of aerial parts of Woodfordia fruticosa (L.) Kurz in Cough Variant Asthma}, journal = {Pharmacognosy Journal}, volume = {7}, year = {2015}, month = {8th June 2015}, pages = {5-5}, type = {Original Article}, abstract = {

Background: Cough variant asthma (CVA) is characterized by prolonged non productive cough which responds to bronchodilator therapy. None of herbal drug is reported to possess pharmacological activity against CVA. Objective: To investigate the pharmacological potential of ethanolic extract of Woodfordia fruticosa (L.) Kurz (EEWF) against CVA as well as to develop an efficient screening model for CVA. Material and Method: Antitussive effect of EEWF was evaluated against nebulized aqueous solution of 0.1 g/ml of citric acid to determine the cough response. EEWF potential was finally accessed against aerosolic mixture of 0.3 g/ml of citric acid mixed with 0.1\% histamine and 2\% acetylcholine chloride to evaluate the convulsive latency, percentage protection and cough frequency against CVA. Results: EEWF at aerosolic dose of 6\% w/v exhibit decrease in of the average coughs frequency (4.83\±0.30) which is quite significant effect as compared to standard drug codeine. EEWF against aerosol induced CVA was found to exhibit a significant bronchoprotection of 41.75\% and decreases number of coughs (7.16\±0.47) at 200 mg/kg as compared to control (14.16\±0.60). Conclusion: EEWF at 200 mg/kg dose exhibited bronchoprotective and antitussive effects against aerosol induced CVA.

Keywords: Acetylcholine, Antitussive, Bronchoprotection, Citric acid, Cough, Cough variant asthma (CVA), Ethanolic extract of Woodfordia fruticosa (L.) Kurz (EEWF), Histamine.

}, keywords = {Acetylcholine, Antitussive, Bronchoprotection, Citric acid, Cough, Cough variant asthma (CVA), Ethanolic extract of Woodfordia fruticosa (L.) Kurz (EEWF), Histamine}, author = {Amit Kumar Srivastava and Srivastava Abhinav Siddharth and Nagar Hemant and Srivastava Rajnish and Deepa and Shukla Gaurav} }