@article {1164, title = {The Extract of Kincung Flower (Etlingera elatior (Jack) R.M.Sm.) Activity to Decrease IL-4 and IgE Levels in Type I Hypersensitivity White Male Mice}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {June 2020}, pages = {682-686}, type = {Original Article}, chapter = {682}, abstract = {

Introduction: Kincung Flower (Etlingera elatior (Jack) R.M.Sm.) is a herbal plant which contains many secondary metabolites. It showed to suppress allergic reactions by inhibiting mast cell degranulation, active cutaneous anaphylaxis and decreasing the number of basophils and eosinophils. Aim: The study conducted to determine the decreased IL-4 and IgE level of type I hypersensitivity male white mice using kincung flowers extract. Materials and Methods: The maceration method used to make ethanol extract of Kincung flower (Etlingera elatior (Jack) R.M.Sm.). The research used 25 allergic male white mice, which made by injected 20\% albumen that given on the first day 0.2 mL/20 g intraperitoneally. On the seventh day are given albumen with the same dose subcutaneously. The characteristic of the allergic mice is the redness at the injection site. It divided into five groups: the negative control group, the positive control group and three dose groups (100; 300; and 1000 mg/kg). After mice given extract for seven days, then measured IgE and IL-4 levels in the serum of mice. Results: The results after three dose groups (100; 300; and 1000 mg/kg) given, the negative and positive control group showed sequentially the IL-4 level was: 33.024; 27.933; 25.192; 23.130 and 41.538 ng/ mL. And IgE level in serum was 0.944; 0.629; 0.210; and 1,597 μg/ mL. Conclusion: It concluded that kincung flowers decreased IL-4 and IgE level significantly (p\<0.05). So it could use as an anti-allergic drug.

}, keywords = {Allergies, Etlingera elatior (Jack) R.M.Sm, IgE, IL-4, Kincung Flower, Mice}, doi = {10.5530/pj.2020.12.100}, author = {Elidahanum Husni and Relin Yesika and Yufri Aldi} } @article {615, title = {Immunoinformatics Study of Procyanidins as Mast Cell Stabilizers}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {May 2018}, pages = {814-817}, type = {Original Article}, chapter = {814}, abstract = {

Background: Allergens are foreign proteins that stimulate the production of immunoglobulin E (IgE), when they come in contact with human body. These allergens after binding with IgE through Fc\εRI receptor, triggers the signal transduction reaction in mast cell and basophil cells, leading to allergic reactions by releasing some mediators. Four correctly written as surface-exposed tryptpphans Trp 87, Trp 110, Trp 113 and Trp 156 of Fc\εRI receptor protein,play significant role in IgE and Fc\εRI receptor binding interaction. Polyphenols in apple are proven effective for allergic rhinitis treatment by preventing degranulation of granulocytes. Objective:To prevent release of mediators like histamine etc., a therapeutic strategy can be designed by inhibiting IgE and Fc\εRI receptor interactions.This strategy may provide a symptomatic treatment for allergic reactions due to exposure to pollen allergens. Materials and methods: Molecular docking studies are used to analyse the IgE with Fc\εRI receptor binding in presence and absence of procyanidin molecules, present in apple. Results: For procyanidin molecules, binding affinity of IgE molecule with its high affinity receptor (Fc\εRI receptor)decreases markedly. Thepositions of Trp 87, Trp 110, Trp 113 and Trp 156 are changed for the presence of procyanidin C1 molecule. Since IgE and Fc\εRI receptor binding is highly affected in presence of procyanidin C1, so this compound can inhibit mast cell degranulation by altering the binding affinity of IgE with its its high affinity receptor (Fc\εRI receptor). Conclusion: Procyanidin C1 can be used as natural anti-allergic drug by stabilizing mast cells during pollen allergic reaction after experimental verification.

}, keywords = {Allergy, IgE, IgE receptor FcεRI, Mast cell stabilizer, Molecular docking, Procyanidins, Tryptophan residues}, doi = {10.5530/pj.2018.4.138}, url = {http://fulltxt.org/article/676}, author = {Anamika Basu and Anasua Sarkar and Piyali Basak} }