@article {2180, title = {Immunomodulatory and Antiallergic Potentials of the Bioactive Compounds of Ginger}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {December 2023}, pages = {1166-1176}, type = {Research Article}, chapter = {1166}, abstract = {

Background: Allergy is an ever-increasing immune disorder and is often fatal under certain circumstances. Lack of total curative medication prompts the search for various compounds as the lead molecules. Ginger, Zingiber officinale Roscoe, is a well-established medicinal plant in different traditional practices. Its use as antiallergic or anti-inflammatory agent has been vindicated but the underlying mechanism of action is yet unknown. Method: In this study, we analyzed the phytocompounds characterized from ginger for their binding affinities on cysteinyl leukotriene receptor 1 (CysLTR1) and histamine H1 receptor (H1R) by molecular docking. The molecular interactions were compared against known agonists and antagonists of the two receptors. Results: The data indicate that ginger compounds have high binding affinity for both LTR1 and H1R comparable to those of antiallergic medications. The highest binding affinities were recorded for gingerenone-A (-7.3 kcal/mol) and zingiberol (-7.2 kcal/mol) on LTR1; and gingerenone-A (-8.7 kcal/mol) and α-curcumene (-8.0 kcal/mol) on H1R. Conclusion: In addition to antiallergic activity, molecular predications on the probable biological activities of the ginger compounds show that they can have a variety of medicinal applications including immunomodulatory and anticancer activities.

}, keywords = {Allergy, Ginger, Histamine Receptor; Leukotriene Receptor, Molecular Modelling}, doi = {10.5530/pj.2023.15.212}, author = {B. Lalruatfela and P. B. Lalthanpuii and C. Lalrinmawia and K. Lalchhandama} } @article {615, title = {Immunoinformatics Study of Procyanidins as Mast Cell Stabilizers}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {May 2018}, pages = {814-817}, type = {Original Article}, chapter = {814}, abstract = {

Background: Allergens are foreign proteins that stimulate the production of immunoglobulin E (IgE), when they come in contact with human body. These allergens after binding with IgE through Fc\εRI receptor, triggers the signal transduction reaction in mast cell and basophil cells, leading to allergic reactions by releasing some mediators. Four correctly written as surface-exposed tryptpphans Trp 87, Trp 110, Trp 113 and Trp 156 of Fc\εRI receptor protein,play significant role in IgE and Fc\εRI receptor binding interaction. Polyphenols in apple are proven effective for allergic rhinitis treatment by preventing degranulation of granulocytes. Objective:To prevent release of mediators like histamine etc., a therapeutic strategy can be designed by inhibiting IgE and Fc\εRI receptor interactions.This strategy may provide a symptomatic treatment for allergic reactions due to exposure to pollen allergens. Materials and methods: Molecular docking studies are used to analyse the IgE with Fc\εRI receptor binding in presence and absence of procyanidin molecules, present in apple. Results: For procyanidin molecules, binding affinity of IgE molecule with its high affinity receptor (Fc\εRI receptor)decreases markedly. Thepositions of Trp 87, Trp 110, Trp 113 and Trp 156 are changed for the presence of procyanidin C1 molecule. Since IgE and Fc\εRI receptor binding is highly affected in presence of procyanidin C1, so this compound can inhibit mast cell degranulation by altering the binding affinity of IgE with its its high affinity receptor (Fc\εRI receptor). Conclusion: Procyanidin C1 can be used as natural anti-allergic drug by stabilizing mast cells during pollen allergic reaction after experimental verification.

}, keywords = {Allergy, IgE, IgE receptor FcεRI, Mast cell stabilizer, Molecular docking, Procyanidins, Tryptophan residues}, doi = {10.5530/pj.2018.4.138}, url = {http://fulltxt.org/article/676}, author = {Anamika Basu and Anasua Sarkar and Piyali Basak} }