@article {68, title = {In vitro Acetyl Cholinesterase Inhibitory assay of Acacia catechu Willd Ethanolic Seed Extract}, journal = {Pharmacognosy Journal}, volume = {7}, year = {2015}, month = {01/2015}, pages = {280-282}, type = {Original Article}, chapter = {280}, abstract = {

Aim \& objective: The aim of this study was to evaluate acetyl cholinesterase inhibitory activity of Acacia catechu ethanolic seed extract to introduce a new source for management of Alzheimer\’s disease. Background: Alzheimer\’s disease is a complex, multifactorial, progressive, neurodegenerative disease primarily affecting the elderly population and is estimated to account for 50\–60\% of dementia cases in persons over 65 years of age. It is likely that the inhibition of acetyl cholinesterase by Acacia catechu ethanolic seed extract that is rich in flavonoids and antioxidants may aid in the protection of neurodegenerative disorders and ultimately Alzheimer\’s disease. Methods: Anti cholinesterase activity is determined by adopting In vitro standard protocol. Results: According to the obtained results, the inhibitory activity (IC50 values, \μg /ml) of extracts was 204.38 \± 2.54 \μg/ ml. Conclusion: The results indicated and confirmed the traditional use of Acacia catechu ethanolic seed extract for management of central nervous system disorders. It showed the moderate activity in inhibition of acetyl cholinesterase at various concentrations. However, further investigations on identification of active components in the extracts are needed.

}, keywords = {Acacia catechu seed, Acetyl cholinesterase inhibitor, Alzheimer{\textquoteright}s disease, Neurodegenerative, Spectrophotometric analysis.}, doi = {10.5530/pj.2015.5.5}, author = {Lakshmi Thangavelu and Rajendran Ramasamy} } @article {1439, title = {In vitro Acetyl cholinesterase inhibitory assay of Acacia catechu Willd ethanolic seed extract}, journal = {Pharmacognosy Journal}, volume = {7}, year = {2015}, month = {9th June 2015}, pages = {1-1}, type = {Original Article}, chapter = {1}, abstract = {

Aim \& objective: The aim of this study was to evaluate acetyl cholinesterase inhibitory activity of Acacia catechu ethanolic seed extract to introduce a new source for management of Alzheimer\’s disease. Background: Alzheimer\’s disease is a complex, multifactorial, progressive, neurodegenerative disease primarily affecting the elderly population and is estimated to account for 50\–60\% of dementia cases in persons over 65 years of age. It is likely that the inhibition of acetyl cholinesterase by Acacia catechu ethanolic seed extract that is rich in flavonoids and antioxidants may aid in the protection of neurodegenerative disorders and ultimately Alzheimer\&$\#$39;s disease. Methods: Anti cholinesterase activity is determined by adopting In vitro standard protocol. Results: According to the obtained results, the inhibitory activity (IC50 values, \μg /ml) of extracts was 204.38 \± 2.54 \µ g/ml. Conclusion: The results indicated and confirmed the traditional use of Acacia catechu ethanolic seed extract for management of central nervous system disorders. It showed the moderate activity in inhibition of acetyl cholinesterase at various concentrations. However, further investigations on identification of active components in the extracts are needed.

Key words: Acacia catechu seed, Acetyl cholinesterase inhibitor, Alzheimer\’s disease, spectrophotometric analysis.

}, keywords = {Acacia catechu seed, Acetyl cholinesterase inhibitor, Alzheimer{\textquoteright}s disease, Spectrophotometric analysis.}, author = {Lakshmi.T and Rajendran.R} } @article {79, title = {Preliminary Phytochemical analysis and In vitro Antioxidant, FTIR Spectroscopy, Anti-diabetic activity of Acacia catechu ethanolic seed extract}, journal = {Pharmacognosy Journal}, volume = {7}, year = {2015}, month = {Nov-Dec 2015}, pages = {356-362}, type = {Original Article}, chapter = {356}, abstract = {

Objective: To evaluate the preliminary phytochemical analysis and in vitro antioxidant activity, anti-diabetic effect of ethanolic seed extract of Acacia catechu against the alpha amylase and alpha glucosidase digestive enzymes in the pancreas and small intestine. Methods: Preliminary phytochemical analysis was done by adopting the method of Evans. Antioxidant assay is performed by DPPH, ABTS and FRAP assay, Anti diabetic activity was determined by modified method of miller, the extract at different concentrations was tested for mammalian alpha amylase and alpha glucosidase enzyme inhibitory assay under the controlled experimental conditions and subjected to determination of absorbance. Results: The present study reveals the presence of few secondary metabolites and the extract exhibits potent Antioxidant activity and a concentration dependent inhibition of Alpha amylase and Alpha glucosidase. Conclusion: From the present study it can be concluded that ethanolic seed extract of Acacia catechu possessed marked in vitro antioxidant and anti-diabetic effect. The effect was plausibly due to the presence of phenolic contents of Acacia catechu

}, keywords = {Acacia catechu seed, Alpha glucosidase, Alpha-amylase, Antidiabetic, Antioxidant, FTIR Spectroscopy, Phytochemical}, doi = {10.5530/pj.2015.6.7}, author = {Thangavelu Lakshmi and Rajendran Ramasamy and Rathinam Thirumalaikumaran} }