@article {1845, title = {Potential of Rhinachanthus nasutus (L.) Kurz Leaves Extract as an Antioxidant and Inhibitor of α-Glucosidase Activity}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {August 2022}, pages = {373-378}, type = {Research Article }, chapter = {373}, abstract = {

Aims: The goal of this study is to learn more about the antioxidant and antidiabetic properties of Rhinachantus nasutus (L.) Kurz (RnLK) leaf extract. The Ultrasound-Assisted Extraction (UAE) technique was used to extract the leaf material, and the solvent used was ethanol with a 70\% concentration. The total phenol content (TPC) of the extracted material was determined. The Cupric Ion Reducing Antioxidant Capacity (CUPRAC) method was used to examine antioxidant activity, whereas α-glucosidase activity was used to test antidiabetic action. Results: The ethanol extract of RnLK leaves yielded 8.36\%, with a TPC of 607.1{\textpm}0.2 mg GAE/g sample. The IC50 value for leaf extract antioxidant activity was 19.1{\textpm}0.1 mg/L. Furthermore, the leaf extract inhibits α-glucosidase activity and has an IC50 value of 81.3{\textpm}3 mg/L, making it an antidiabetic. Conclusion: The ethanolic extract of RnLK leaves can be used as an alternative antioxidant and antidiabetic material, according to the findings of this study.

}, keywords = {Anti-diabetic, CUPRAC method, RnLK, UAE, α-glucosidase activity}, doi = {10.5530/pj.2022.14.110}, author = {Candra Irawan and Berna Elya and Muhammad Hanafi and Fadlina Chany Saputri} } @article {1075, title = {Comparative Pharmacognostical and Pharmacological Evaluation of Costus speciosus (Koen) J.E. Sm. Germplasm Collected from Eastern Ghats of India}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {February 2020}, pages = {150-156}, type = {Research Article}, chapter = {150}, abstract = {

Background: Costus speciosus is an erect perennial herb belonging to family Costaceae, an important medicinal plant widely used in several indigenous medicinal formulations. Objective: A comparative evaluation of Pharmacognostical and Pharmacological potential of Costus speciosus for the validation of traditional claims and quality parameters for industry. Materials and Methods: Pharmacognostical studies were performed as per Ayurvedic Pharmacopeia of India and quantification of diosgenin was done through HPTLC. In vitro antidiabetic activity was evaluated by α-amylase inhibition assay based on starch iodine method and in vitro anti-inflammatory were done by using inhibition of protein denaturation assay. Results: The pharmacognostical standards were also laid down for each sample. Morpho-anatomical characters had no distinct variation in all the collected samples of Eastern Ghats. The quantification of diosgenin (without hydrolysis of samples) in the collected germplasm varies significantly from 0.002 to 0.076 \% on dry weight basis. The maximum content was recorded in NBCS-06 from Patiya, Bhubaneswar and was identified as distinct chemotype with high metabolite content. IC50 value of Costus speciosus extract in starch-iodine assay was found to be maximum in NBCS- 6 (87.54 μg/ml) and inhibition of protein denaturation assay was found to be maximum in NBCS- 11 (73.91 μg/ml), respectively. Conclusion: The study suggests that the Costus speciosus germplasm possess potential anti-inflammatory and anti-diabetic activity and comparative pharmacognostical parameters will be useful in collection of location specific potential samples for industrial usage along with quality control of raw materials.

}, keywords = {Anti-diabetic, Anti-inflammatory, Costus speciosus, Diosgenin, HPTLC}, doi = {10.5530/pj.2020.12.22}, author = {Manish Kumar and Ankita Misra and Akanksha Srivastava and Pushpendra Kumar Shukla and L M Tewari and Sharad Srivastava} } @article {1265, title = {A Critical Review on Ethnobotanical and Pharmacological Aspects of Euryale Ferox Salisb.}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {September 2020}, pages = {1444-1454}, type = {Review Article}, chapter = {1444}, abstract = {

Introduction: One of the relished dry fruits known by the names of Makhana, Phool Makhana, Gorgon Nut and Fox Nut in the Indian continent, Euryale ferox Salisb. (Nymphaeaceae) is the only plant that belongs to Euryale genus. It is found in abundance in Mithila, Darbhanga and Madhubani region of Bihar state. Since ages, in Ayurveda and Chinese practices, it has been used for the treatment of the renal disorder, chronic diarrhoea, excessive leucorrhea and hepatic dysfunctioning. Its bio-active compounds act as antioxidant, antimicrobial, antiischaemic, anti-diabetic, immunomodulatory, anti-melanogenic, anti-cytotoxic. Methods: The information has been collected from various scientific journals, reviews, books, reports and patent databases. Results: This review summarizes the isolated bioactive compounds in different extracts, patented compounds/formulations with pharmacological activities, present in different parts of Euryale ferox Salisb. Hence, it has been used as a remedy for numerous ailments since long and also proves itself as a panacea for humanity.

}, keywords = {Anti-aging, Anti-cytotoxic, Anti-diabetic, Cerebrosides, Ethnobotanical, Euryale ferox}, doi = {10.5530/pj.2020.12.199}, author = {Roopal Mittal and Shailesh Sharma and Amit Mittal} } @article {794, title = {Evaluation of Pharmacological Properties of Caesalpinia bonducella Seed and Shell Extract}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {January-2019}, pages = {150-154}, type = {Original Article}, chapter = {150}, abstract = {

Background: Caesalpinia bonducella L. is a medicinal plant belonging to the family Caesalpiniaceae. It is a prickly shrub widely distributed all over the world especially in Indian tropical regions such as Kerala, Andaman and Nicobar Islands and Sri Lanka. There are claims that its leaves or seeds/ seed kernel possess antipyretic, antidiuretic, antibacterial, antiviral, antiestrogenic and antidiabetic activities Due to the above properties several preparations of the plant were used in folk medicine. Materials and Methods: The aqueous extract of Caesalpinia bonducella nut containing the seed and the shell, has been evaluated for qualitative analysis of secondary metabolites (tannis, flavonoids, alkaloids, saponins, coumarins, quinone and phenols), in-vitro anti -inflammatory, anti-diabetic assay, antioxidant, antimitotic and antimicrobial activity. The studies were carried out using HRBC membrane stabilization, inhibition of alpha amalyse enzyme, DPPH method, green gram growth inhibition, agar diffusion method respectively. Results: Our results indicate the presence of Alkaloids, Flavanoids and Saponins. We report in our study the antidiabetic, anti-inflammatory, anti-oxidant, anti-microbial and antimitotic activity of Caesalpinia bonducella.

}, keywords = {Anti-diabetic, Anti-inflammatory, Anti-mitotic, Anti-oxidant, Caesalpinia bonducella}, doi = {10.5530/pj.2019.1.25}, author = {Vigasini Subbiah and Pannaga Nagaraja and Priya Narayan and Holenarasipur GunduRao Nagendra} } @article {581, title = {Anti-Diabetic, Anti-Oxidant and Anti-Adipogenic Potential of Quercetin Rich Ethyl Acetate Fraction of Prunus persica}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {March 2018}, pages = {463-469}, type = {Original Article}, chapter = {463}, abstract = {

Background: Diabetes mellitus is enfeebling threatening diseases with continuously increasing rates of incidence and mortality and it may rise tremendously by 2025. Objective: Quercetin rich ethyl acetate fraction (PP-EtOA) of leaves of Prunus persica was evaluated for antidiabetic, anti-oxidant and anti-adipogenic activities. Material and Methods: Streptozotocin (STZ)-induced diabetic rat model, oral glucose tolerance test (OGTT) and normalglycemic rat models were investigated at the doseof 100 and 200 mg/kg,p.o. of PP-EtOA. Results: At 200 mg/kg, significant anti-hyperglycaemic activity(p\<0.05) was observed in all the rat models. In STZ induced diabetic rat model, improvement in body weight and lipid profile was also observed.DPPH (2,2\’-diphenyl-1-picrylhydrazyl) free radical scavenging method showed dose dependent scavenging. Preadipocyte differentiation assay (3T3-L1) showed significant inhibition of differentiation. HPLC fingerprinting analysis of fraction was also performed. Conclusion: PP-EtOA possesses potent free radical scavenging property. Its antihyperglycemic and antiadipogenic activities may be due to quercetin (flavonoid) and may prove to be effective in the treatment of diabetes mellitus and diabetes driven dyslipidemic conditions.

}, keywords = {Anti-adipogenic, Anti-diabetic, Anti-oxidant, Prunus persica, Quercetin}, doi = {10.5530/pj.2018.3.76}, url = {http://fulltxt.org/article/509}, author = {Gaurav Sharma and Sunil Kumar and Megha Sharma and Navneet Upadhyay and Sunil Kumar and Zabeer Ahmed and Neeraj Mahindroo} } @article {760, title = {Phytochemical Screening, LC-MS Studies and Antidiabetic Potential of Methanol Extracts of Seed Shells of Archidendron bubalinum (Jack) I.C. Nielson (Julang Jaling) from Lampung, Indonesia}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {November 2018}, pages = {s77-s82}, type = {Original Article}, chapter = {s77}, abstract = {

Background: Some Malaysia and Indonesia people believed that root and seed shell of Archidendron bubalinum can treat diabetes. However, seed shell of Archidendron bubalinum has not yet to be scientifically proven and confirmed their ability to treat diabetes. The study of the potential of this seed shell was also scarcely available. Objective: The recent work was aimed to investigate the phytochemical screening of methanol extracts of seed shells of Archidendron bubalinum and to evaluate their chemical compositions and antidiabetic activities. Material and Methods: The methods of phytochemical screening were including alkaloids, flavonoids, tannins, polyphenols, saponins, and terpenoids. Their chemical compositions were determined by Liquid Chromatography-Mass Spectrometry (LC-MS) and antidiabetic activities were performed by \α-glucosidase inhibitory method. Results: The phytochemical screening showed that methanol extracts of seed shells of Archidendron bubalinum contain flavonoids, tannins, polyphenols, and terpenoids. This extracts exhibited antidiabetic activity with IC50 7.77 \μg/mL. This result was supported by LC-MS analysis which showed the presence of phlorizin and astilbin, in which these compounds had high inhibitory activity against \α-glucosidase or diabetes. Conclusion: LC-MS analysis revealed the presence of polyphenol compounds namely phlorizin and astilbin in which had high \α-glucosidase inhibitory activity, might largely contribute in the antidiabetic activity. Key words: Phytochemical screening, Mass spectrometry

}, keywords = {Anti-diabetic, Archidendron bubalinum, Mass spectrometry, Phytochemical screening}, doi = {10.5530/pj.2018.6s.15}, author = {Hanafi and Candra Irawan and Henny Rochaeni and Lilis Sulistiawaty and Achmad Nandang Roziafanto and Supriyono} } @article {1482, title = {Anti-diabetic, Hypolipidemic and Anti-oxidant Activities of Hydroethanolic Root Extract of Rhus Mysurensis Heyne in Streptozotocin Induced Diabetes in Wistar Male Rats}, journal = {Pharmacognosy journal}, volume = {6}, year = {2014}, month = {8th April 2014}, pages = {62-71}, type = {Original Article}, abstract = {

Objectives: The present study was designed to investigate the potential role of hydroethanolic root extracts\  were Rhus mysurensis (HERM) in the treatment of diabetes along with its antioxidant and antihyperlipidemic effects was studied in streptozotocin induced diabetes in Wistar rats. Methods: In this study, the anti-diabetic, hypolipidemic and anti-oxidant activities of hydroethanolic root extract of Rhus mysurensis was evaluated by using STZ induced diabetic rats at a dose of 200 mg/kg, 400 mg/kg and 800 mg/kg p.o. daily for 21 days. Blood glucose levels and body weight were monitored at specific time intervals, and different biochemical parameters, serum cholesterol, serum triglyceride, high density lipoprotein, low density lipoprotein were also assessed in the experimental animals. Results: Oral administration of hydroethanolic root extracts of Rhus mysurensis (HERM) 400 and 800 mg/kg for 21 days significantly decreased the blood glucose level and considerably increased the body weight of diabetic induced rats. Daily oral treatment with HERM for 3 weeks resulted in reduced serum cholesterol, and triglycerides and improved HDL-cholesterol levels when compared to the diabetic control group. HERM significantly decreased thiobarbituric acid reactive substances (TBARS) and significantly increased superoxide dismutase and catalase in streptozotocin-induced diabetic rats at the end of 21 days of treatment. Conclusion: Hydroethanolic root extract of Rhus mysurensis showed significant anti-diabetic, hypolipidemic and anti-oxidant activities, which provide the scientific proof for its traditional claims. The results also put forward that the HERM is promising for development of standardized phytomedicine for the treatment of diabetes mellitus.

Key words: Anti-diabetic, anti-oxidant, hypolipidemic, Rhus mysurensis.

}, keywords = {Anti-diabetic, Anti-oxidant, Hypolipidemic, Rhus mysurensis.}, author = {Sanwar Mal Lamba, and Kunjbihari Sulakhiya, and Parveen Kumar, and Mangala Lahkar, and Chandana C. Barua, and Babul Bezbaruah} } @article {1542, title = {Evaluation of Anti-Diabetic Activity of Methanolic Extract from the Leaves of Rotula Aquatica Lour in Alloxan-Induced Diabetic Rats}, journal = {Pharmacognosy Journal}, volume = {6}, year = {2014}, month = {18th Feb,2014}, pages = {110-114}, type = {Original Article}, chapter = {110}, abstract = {

Objective: The objective of the present study was to evaluate the anti-diabetic activity of methanolic extract from the leaves of Rotula aquatica lour in Alloxan-induced diabetic rats. Materials and Methods: Diabetes was induced in rat by injection of Alloxan (120 mg/kg, i.p.). Diabetic rats were divided into different groups and methanolic leaves extract of Rotula aquatica lour (RA-ME) was administered at dose ranges of 100\–400 mg/kg, p.o for 21 days. Control group received normal saline (0.9\%) for 21 days. Glibenclamide (5 mg/kg, p.o) was used as standard drug. Blood samples were collected from all the groups and analyzed for serum glucose and lipid levels such as total cholesterol (TC), triglyceride (TG), proteins (TP). RA-ME was also tested for oral glucose tolerance test (OGTT) in normal fasted rats. Results: RA-ME (400 mg/kg, p.o) showed a significant (P\<0.01) reduction of serum glucose level in Alloxan-induced diabetic mice as compared with diabetic control. RA-ME (200 and 400 mg/kg) also showed a significant reduction in serum TC, TG, and TP levels in Alloxan-induced diabetic rats. RA-ME (200 and 400 mg/kg, p.o) significantly (P\<0.01) increased the glucose tolerance in OGTT. Conclusion: The results obtained from the present study revealed the potential anti-diabetic activity of methanolic extract from the leaves of Rotula aquatica lour.

Key words: Alloxan, Anti-diabetic, Glibenclamide, Rotula aquatica lour.

}, keywords = {Alloxan, Anti-diabetic, Glibenclamide, Rotula aquatica lour.}, author = {Bhanu Priya, and Manoj Gahlot, and Punam Joshi, and Sarika Zade, and Ujwala Bagmar} }