@article {863, title = {Clinical Uses and Toxicity of Aloe vera: An Evidence-Based Comprehensive Retrospective Review (2007-2017)}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {February 2019}, pages = {424-428}, type = {Review Article}, chapter = {424}, abstract = {

Background: Aloe vera (AV), mostly known as succulents, or the healing plant of the genus Aloe of Liliaceae family. It contains large range of vitamins, amino acids, antiseptic, antiinflammatory, and sulfur compounds to control and eliminate mold, bacteria, viruses; however, AV toxicity is most of the times described poorly among AV consumers. Aim of the Study: To report and highlight AV clinical uses and toxicity cases to compare and highlight its therapeutic as well toxic profile. Materials and Methods: AV cases were gathered from databases such as Google Scholar, PubMed, Web of Science, Scopus, and E-Resource Portal of Imam Abdulrahman bin Faisal University using the keywords, i.e., AV case report, AV toxicity, hepatitis, clinical trials about AV, interactions, the current uses of AV, etc. Results: Ten cases met the eligibility criteria where the toxicities were mostly associated with the usage of AV except the intended use, i.e., to be administered topically or AV capsules ingestion or as a drinkable solutions. Major symptoms observed in these cases were related to hepatocytes inflammation (hepatitis), fatigue, nausea, vomiting, thyroid dysfunction, abdominal discomfort, and diarrhea along with severe weight loss. These results were not associated with a specific age; however they were more predominant in female gender. Conclusion: AV should be taken within normal/specified dose range which can only be achieved through asking an herbal specialist, and in approved suitable dosage form which is topical.

}, keywords = {Acemannan, Aloe vera, Cosmetics, Hepatitis, Toxicity}, doi = {10.5530/pj.2019.11.66}, author = {Ahmed Muhammad Ibrahim and Hussain Al Sadah and Rizwan Ahmad and Niyaz Ahmad and Atta Abbas Naqvi} } @article {834, title = {Comparison between the Effect of Precipitate and Supernatant Aloe vera Gel on Experimental Cutaneous Wound Healing Using Optical Coherence Tomography}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {February 2019}, pages = {405-412}, type = {Original Article}, chapter = {405}, abstract = {

Background: Wound healing is a fundamental response to injured tissue that results in the restoration of tissue integrity. One of the famous herbs that promote wound healing is Aloe vera. Despite well known for its therapeutic effect, several studies reported inconclusive evidence regarding this. Besides, lack of evidence to postulate the superior effect of two components of Aloe vera which are the precipitate and supernatant. Objective: Study compares the effects of precipitate and supernatant in promoting tissue repair. Evaluation takes place by using optical Coherence Tomography (OCT) and is comparable with histopathology study. Methods: Twelve male mice were randomly divided into four groups (precipitate, supernatant, control 50\% ethanol, and normal). 200 mg of Aloe vera was extracted. A standardized 2 cm longitudinal incision wound was created. All mice were given topical Aloe vera, 0.5 g each, once daily and assessment of wound surface was performed using OCT. The animals were sacrificed on day 10 to evaluate histopathologically. Results: R parameter from the OCT was utilized to analyze the data. There is no significant difference in the treatment effect between Aloe vera treated group and control on day 10 post-injury. Treated animals with precipitate did not differ significantly from supernatant treated group. Nevertheless, from histopathology analysis, precipitate showed better wound reepithelialisation, collagen formation and angionesis despite having numerous inflammatory cells. Conclusion: OCT using R parameter is not the best choice to detect wound healing. Nevertheless, from histopathological perspective, Aloe vera accelerates wound healing and precipitate Aloe vera gel does have a superior effect from supernatant in promoting wound healing.

}, keywords = {Aloe vera, OCT, Precipitate, Supernatant, Wound Healing}, doi = {10.5530/pj.2019.11.63}, author = {Kusmardi Kusmardi and Nurrashida Binti Mok Hallim and Aryo Tedjo and Anwar Ibrahim and Salinah} } @article {456, title = {Aloe Vera (Medicinal Plant) Research: A Scientometric Assessment of Global Publications Output during 2007-16}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {December 2017}, pages = {1-8}, type = {Invited Article}, chapter = {1}, abstract = {

The paper examines 1988 global publications on Aloe Vera research, as covered in Scopus database during 2007-16. The Aloe Vera research registered 3.91\% growth and averaged its citation impact to 9.57 citations per paper. The top 12 most productive countries individually contributed global share 5.36\% to 52.17\%. India accounted for the largest global publication share (32.55\%), followed by USA (11.52\%), Iran (8.15\%), China (4.63\%) etc. Together, the top 12 countries accounted for 79.18\% global publications share and 84.94\% global citation share during 2007-16. Seven of top 12 countries scored relative citation index above the world average i.e. 1.04: U.K. (1.82), Thailand and USA (1.63 each), Spain (1.23), Pakistan and China (1.15 each) and Italy (1.12) during 2007-16. The country share of international collaborative publications across top 12 most productive countries varied from 5.36\% to 52.17\%, in Aloe Vera research during 2007-16. Medicine, among other subjects, accounted for the highest publications share (40.90\%), followed by pharmacology, toxicology and pharmaceutics (35.16\%), agricultural and biological sciences (23.09\%), biochemistry, genetics and molecular biology (20.27\%), chemistry (7.90\%), immunology and microbiology (6.24\%) and engineering (5.38) during 2007-16. The top 20 most productive research organizations and the authors collectively contributed 11.47\% and 8.55\% respectively global publication share and 12.87\% and13.82\% respectively global citation share during 2007-16. The journals medium accounted for the largest 79.08\% global share with top 15 journals accounting for just 16.01\% of total output that was reported in journals during 2007-16. Only 18 papers in Aloe Vera research registered 100 plus citations between 104 to 242 citations per paper, and together these papers cumulated 2656 citations, averaging to 147.55 citations per paper. These 18 highly cited papers involved the participation of 66 authors and 41 organizations and were published in 15 journals.

}, keywords = {Aloe vera, Bibliometrics, Global research output, Medicinal plant, Scientometrics}, doi = {10.5530/pj.2018.1.1}, url = {http://fulltxt.org/article/356}, author = {BM Gupta and KK Mueen Ahmed and SM Dhawan and Ritu Gupta} }