@article {763, title = {Antioxidant Capacity and Cytotoxicity of the Aqueous Extract of Myrcia guianensis (Aubl.) DC}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {November 2018}, pages = {s135-s140}, type = {Original Article}, chapter = {s135}, abstract = {

Introduction: Ethnobotanical studies report that Myrcia guianensis (Myrtaceae), belonging to a group of plants known as pedr\á-ume-ca\á or insulin plant, is used as a tea to treat various diseases, including diabetes, a metabolic disorder that leads to the constant production of free radicals. The objective of this work was to determine the antioxidant capacity and the cytotoxicity of the AEMg. Methods: The content of phenolic compounds in AEMg was determined by colorimetric assays. In vitro tests of the antioxidant capacity of AEMg, in the sequestration of DPPH radicals, in \β-carotene bleaching, in the FRAP, as well as in human fibroblast cells of the MRC-5 lineage, were performed. The cytotoxic activity of AEMg was evaluated in assays with eukaryotic cells from yeast Saccharomyces cerevisiae and in PBMC. Results: The results showed that the AEMg is rich in phenolic compounds, presenting high antioxidant potential in all the tests carried out, including in human fibroblast cells of the MRC-5 lineage, besides not being toxic to eukaryotic cells. Conclusion: The AEMg, rich in antioxidant compounds and no toxicity, can be used as source of natural antioxidant in the treatment of metabolic diseases to combat free radicals.

}, keywords = {antioxidant activity, Myrtaceae, Oxidative stress, Pedra-ume-ca{\'a}, Phenolic compounds}, doi = {10.5530/pj.2018.6s.25}, author = {Regiane Sablina Almeida Bernardes and Sandra Layse Ferreira Sarrazin and Flaviana Alves dos Santos and Moacyr Jesus Barreto de Melo R{\^e}go and Maira Galdino da Rocha Pitta and Marina Ferraz Cordeiro and Patr{\'\i}cia Danielle Oliveira de Almeida and Ricardo Bezerra de Oliveira and Leoneide {\'E}rica Maduro Bouillet and Jos{\'e} Guilherme Soares Maia and Rosa Helena Veras Mour{\~a}o} } @article {445, title = {Isolation and Identification of Compounds from the Leaf Extract of Melaleuca alternifolia}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {November 2017}, pages = {s52-s55}, type = {Original Article}, chapter = {s52}, abstract = {

Introduction: Melaleuca alternifolia also known as Tea tree oil belonging to family Myrtaceae. This plant has diverse and therapeutic uses in traditional herbal medicine for treating Skin care, First Aid, Household Cleaning, Hair care, Aromatherapy, Feminine care, Chronic illness, and Dental care in Australia.\ Method: The methanolic extract of Melaleuca alternifolia family Myrtaceae was subjected for Soxhlet extraction in round bottomed flask with petroleum ether. The petroleum ether extracted leaf powder was dried and once again subjected to Soxhlet extraction successively with different solvents viz, chloroform, ethyl acetate and methanol. Result: The IR spectra showed characteristic absorption bands at 3421 cm-1 indicating the presence of a OH group, at 1691cm-1 for C=O group, 2848 cm-1. The 1HNMR spectra showed a triplet signal at \δ 10.44, 9.48, 13.21 showing the presence of OH group and Carboxylic acid. The 13C NMR spectra showed signals at \δ 16.28 for a methyl carbon, \δ 29.89 for a methylene carbon, The ESI-negative mode mass spectrum showed pseudo molecular ions at m/z 515 for [M+] ion. Conclusion: Based on spectral analysis and comparison of the spectral data with literature values, the compounds were identified as 3,3\’dimethylellagic acid and its aglycone portion with some little impurity.

}, keywords = {3, 3{\textquoteright}dimethylellagic acid, Aromatherapy, Chloroform, Melaleuca alternifolia, Methalonic, Myrtaceae}, doi = {10.5530/pj.2017.6s.157}, url = {http://fulltxt.org/article/381}, author = {Gagan Shah and Dhandeep Singh and Uttam Singh Baghel} } @article {1523, title = {Isolation of Phytochemicals From Anticancer Active Extracts of Syzygium alternifolium Walp. Leaf}, journal = {Pharmacognosy Journal}, volume = {6}, year = {2014}, month = {26th May 2014}, pages = {83-85}, type = {Research Article}, abstract = {

Objective: The aim of the present study was to isolate the phyto molecules from the leaf of endemic medicinal pant, Syzygium alternifolium. The phytochemical investigation of the leaf of the plant yielded a flavonoid Eucalyptin 1 and a triterpinoid Epibetulinic acid 2 in pure state. Results: The compound 1 is being reported for the first time from this plant. The anti-cancer activity showed leaf hexane extract (IC50 values 8.177 and 2.687 \µg/ml) was significantly active, when compared to extracts and compounds, against human cancer cell lines MCF-7 and DU-145. Also, hexane extract potentially inhibited the growth of DU-145 cell lines when compared with the reference compound doxorubicin. Amongst the isolated compounds, 1 was better cytotoxic than 2. Conclusion: The hexane extract of leaves of S. alternifolium yielded compounds 1 and 2 and the structure elucidation, based on spectroscopy, revealed them as Eucalyptin and Epibetulinic acid respectively. The compound 1 is being reported for the first time from this plant. The anti-cancer activity showed leaf hexane extract (IC50 values 8.177 and 2.687 mg/mL) was significantly active, when compared to extracts and compounds, against human cancer cell lines MCF-7 and DU-145. Also, hexane extract potentially inhibited the growth of DU-145 cell lines when compared with the reference compound doxorubicin. Amongst the isolated compounds, 1 was better cytotoxic than 2.

Key Words: Syzygium alternifolium, Myrtaceae, Eucalyptin, Epibetulinic acid, anticancer activity.

}, keywords = {Anticancer activity, Epibetulinic acid, Eucalyptin, Myrtaceae, Syzygium alternifolium}, author = {B. Komuraiah and Srinivas Chinde and A. Niranjana Kumar and K.V.N. Satya Srinivas and Ch. Venu and J. Kotesh Kumar and K.P. Sastry and Paramjit Grover} }