@article {1359, title = {Medicinal Value of Three Agricultural Weed Species of the Asteraceae Family: A Review}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {January 2021}, pages = {264-277}, type = {Review Article}, chapter = {264}, abstract = {

Ageratum conyzoides L., Tridax procumbens L. and Bidens pilosa L. are well known plant species of the Asteraceae family that are considered weeds in intensive agriculture. These weeds are traditionally known to have medicinal properties and have been used for therapeutic treatments. However, it is only the lack of proper knowledge, awareness and screening that have limited their use in pharmaceutical sectors. This review attempts to consolidate the traditional, phytochemical and pharmacological studies that have been carried out on Ageratum conyzoides L., Tridax procumbens L. and Bidens pilosa L., which we note are widely spread throughout the world. This study was conducted through a coherent search on Ageratum conyzoides L., Tridax procumbens L. and Bidens pilosa L. with respect to traditional uses, phytochemical and pharmacological studies that have been performed on these three agricultural weeds all over the world. An exploration of reported descriptions of the potential medical importance of three agricultural weed species (A. conyzoides, T. procumbens and B. pilosa) has been presented. The present review would encourage further clinical investigations into these three plants and their extracts to more closely define the range of uses of these herbs for clinical applications. This, in turn, would give a clear understanding whether these weed species might be targeted to be conserved in a sustainable manner rather than eradicated.

}, keywords = {Ageratum conyzoides, Bidens pilosa, Pharmacological, Phytochemical, Traditional use, Tridax procumbens}, doi = {10.5530/pj.2021.13.36}, author = {Mithila Jayasundera and Singarayer Florentine and Kushan U Tennakoon and Bhagirath Singh Chauhan} } @article {405, title = {Influence of Extraction Parameters on the Yield, Phytochemical, TLC-Densitometric Quantification of Quercetin, and LC-MS Profile, and how to Standardize Different Batches for Long Term from Ageratum conyoides L. Leaves}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {September 2017}, pages = {767-774}, type = {Original Article}, chapter = {767}, abstract = {

Introduction: Ageratum conyzoides Linn is one of the Indonesian herbs are used as folk medicine. There are many studies to the therapeutic activity. However, the study of the influence in extraction parameters and how to standardize different batches of plant is still limited. Objective: The present study was designed to investigate the influence of extraction parameters on the variables matter, yield, phytochemical profile, and total quercetin from A. conyzoides L. leaves extract. The study also evaluates Liquid Chromatography-Mass Spectroscopy (LC-MS) and TLC fingerprint profiles of the extract to determine the proper quality of plant material of A. conyzoides L. leaves. Methods: Different temperatures (from 0\°C to 60\°C), solvent types (water and 70\% ethanol (\%v/v), and extraction time (192 h VS 2 h) were used to investigate the influence of extraction parameters. The profiles of extract were performed by TLC and LC-MS method. Results: The extract yield was influenced by temperature, solvent types, and time extraction. Our results suggest that the digestion technique at 60\°C with 70\% ethanol for 2h was recommended for the extraction method to obtained high yield and quercetin content as bioactive compound in A. conyzoides L. leaves extract. The range of quercetin content (40\–52 ppm) combined with TLC and LC-MS profile can be used to determine the proper quality of plant material. Conclusion: All parameter of extraction have an affect on the yield extract and total quercetin on the final extract. Thus, there is a need an optimized method to obtain the suitable method.

}, keywords = {Ageratum conyzoides, Lc-Ms, Quercetin, Standardization., Tlc-Densitometric}, doi = {10.5530/pj.2017.6.121}, url = {http://fulltxt.org/article/174}, author = {Anita Paulina Tambunan and Anton Bahtiar and Raymond Rubianto Tjandrawinata} } @article {1448, title = {Anxiolytic Potential of Methanol Extract from Ageratum conyzoides Linn Leaves}, journal = {Pharmacognosy Journal}, volume = {7}, year = {2015}, month = {29th Apr, 2015}, pages = {236-241}, type = {Original Article}, chapter = {236}, abstract = {

Objective: Ageratum conyzoides Linn. (Asteraceae) has been widely used in African traditional medicine for healing mental and infectious diseases. The present study was designed to scientifically validate the traditional claim of A. conzyoides as anti-anxiety drug and to identify the compound responsible for the anxiolytic effects of A. conzyoides. Method: The methanol extract of A. conzyoides was prepared by soxhlet apparatus. The methanol extract was fractionated into ethylacetate and butanol fractions by liquid-liquid partitioning method. Methanol extract (100 and 200 mg/kg; p.o.) and its prepared fractions (25 and 50 mg/kg; p.o.) were evaluated for anxiolytic activity in mice by using elevated plus maze (EPM) model. Thin layer chromatography studies were performed to identify the possible anxiolytic component. Results: Methanol extract at both doses showed significant, when compared to vehicle control group, increase in time spent and number of entries in open arms of EPM confirming the anti-anxiety effects of A. conzyoides. Liquid-liquid partitioning of methanol extract gave two fractions (ethylacetate and butanol) which were administrated at 25 and 50 mg/kg doses to mice in EPM, respectively. Results showed that ethylacetate fraction was responsible for anxiolytic effects of methanol extract of A. conzyoides. The TLC studies were carried out for ethylacetate fraction and Quercetin was identified by comparing Rf values with the standard (Quercetin). Conclusion: The present investigation revealed that the extract has significant anxiolytic effect. The flavonoid quercetin may be responsible for the observed anxiolytic effects of A. conyzoides.

Key words:Ageratum conyzoides, Anxiolytic, Methanol extract, Quercetin, TLC.

}, keywords = {Ageratum conyzoides, Anxiolytic, Methanol extract, Quercetin, TLC.}, author = {Ravinder Kaur and Sarabjit Kaur} } @article {58, title = {Anxiolytic Potential of Methanol Extract from Ageratum conyzoides Linn Leaves}, journal = {Pharmacognosy Journal}, volume = {7}, year = {2015}, month = {Jul-Aug 2015}, pages = {236-241}, type = {Original Article}, chapter = {236}, abstract = {

Objective: Ageratum conyzoides Linn. (Asteraceae) has been widely used in African traditional medicine for healing mental and infectious diseases. The present study was designed to scientifically validate the traditional claim of A. conzyoides as anti-anxiety drug and to identify the compound responsible for the anxiolytic effects of A. conzyoides. Method: The methanol extract of A. conzyoides was prepared by soxhlet apparatus. The methanol extract was fractionated into ethylacetate and butanol fractions by liquid-liquid partitioning method. Methanol extract (100 and 200 mg/kg; p.o.) and its prepared fractions (25 and 50 mg/kg; p.o.) were evaluated for anxiolytic activity in mice by using elevated plus maze (EPM) model. Thin layer chromatography studies were performed to identify the possible anxiolytic component. Results: Methanol extract at both doses showed significant, when compared to vehicle control group, increase in time spent and number of entries in open arms of EPM confirming the anti-anxiety effects of A. conzyoides. Liquid-liquid partitioning of methanol extract gave two fractions (ethylacetate and butanol) which were administrated at 25 and 50 mg/kg doses to mice in EPM, respectively. Results showed that ethylacetate fraction was responsible for anxiolytic effects of methanol extract of A. conzyoides. The TLC studies were carried out for ethylacetate fraction and Quercetin was identified by comparing Rf values with the standard (Quercetin). Conclusion: The present investigation revealed that the extract has significant anxiolytic effect. The flavonoid quercetin may be responsible for the observed anxiolytic effects of A. conyzoides.

}, keywords = {Ageratum conyzoides, Anxiolytic, Methanol extract, Quercetin, TLC}, doi = {10.5530/pj.2015.4.5}, author = {Ravinder Kaur and Sarabjit Kaur} }