@article {1636, title = {Anti-diabetic Activity of the Red Dragon Fruit Peel (Hylocereus polyrhizus) in Ethanol Extract against Diabetic Rats}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {September 2021}, pages = {1079-1085}, type = {Original Article}, chapter = {1079}, abstract = {

Background: The red dragon fruit peel, which is rarely used in general, contains higher antioxidant properties compared to the flesh parts and has various secondary metabolites utilised in medicines. Objectives: This study was aimed to determine the effects of ethanol extract administration of the red dragon fruit peel (Hylocereus polyrhizus) against the decline of blood glucose levels in diabetes mellitus rats. Methods: In this study, the total of 24 male white Wistar rats (Rattus novergicus) were divided into 4 groups. All experimental animals were induced to diabetic conditions by the administration of streptozotocin and nicotinamide dosages at 45 mg/kg body weight and 110 mg/kg body weight, respectively. For 14 days, each group was treated accordingly. The first group or negative control (NC) was treated with the administration of CMC-Na 0.5\% dose 2 ml/200 g body weight; the second group or positive control (PC) was administrated with glibenclamide dose 0.09 mg/200 g body weight; the third (E1) and fourth (E2) groups were administered with the ethanol extracts of the red dragon fruit peels at dosages of 37.44 mg/200 g body weight and 74.88 mg/200 g body weight, respectively. Results: After the 14-day trial, the average levels of blood glucose on the negative control group (382.92 mg/dl) experienced no decline, and the blood glucose levels amongst groups were statistically different (p\<0.05). Conclusion: The anti-diabetic activity of the red dragon fruit peel in the ethanol extract dose 74.88 mg/200 g body weight is statistically equal to the glibenclamide dose 0.09 mg/200 g body weight.

}, keywords = {Antidiabetic activity, Diabetic rats, Hylocereus polyrhizus}, doi = {10.5530/pj.2021.13.140}, author = {Ruqiah Ganda Putri Panjaitan and Novitasari} } @article {1237, title = {Effect of Afghan Senjed (Elaeagnus Angustifolia L.) Leaves Aqueous alcoholic Extract on Blood Glucose Level of Diabetic Rats}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {September 2020}, pages = {1218-1222}, type = {Original Article}, chapter = {1218}, abstract = {

Introduction: Diabetes mellitus is a metabolic disorder, which affects many people throughout the world. The inefficacy and multiple side effects of most synthetic anti-diabetic drugs are reported by various studies. Thus, many researchers are focused on the use of medicinal plants as safe and potent anti-hyperglycemic drugs. The aim of this study is the evaluation of the effect of Afghan senjed (Elaeagnus Angustifolia L.) leaves aqueous alcoholic extract on blood glucose level of diabetic rats. Methods: Rats were divided into 6 groups: normal, diabetic, metformin and Elaeagnus Angustifolia leaves extract (EALE) groups, which received 200, 400 and 800 mg/kg doses of extract for 15 days. Diabetes was induced by single dose intraperitoneal administration of streptozotocin (STZ). During treatment, the effect of single and repeated oral administration of EALE on blood glucose level of diabetic rats was evaluated. On last day, the effect of EALE on oral glucose tolerance test (OGTT) was also assessed. Results: All doses of EALE showed significant reduction in blood glucose level, an improvement of glucose tolerance and enhancement in body weight. Conclusion: EALE possessed an antihyperglycemic property in diabetic rats.

}, keywords = {Blood glucose level, Diabetic rats, Elaeagnus Angustifolia leaves, Glucose tolerance, Streptozotocin}, doi = {10.5530/pj.2020.12.170}, author = {Hamida Sadat and Kawsar Alami and Sayed Yousof Mousavi} } @article {358, title = {Antihyperglycemic Effect of Silkworm Powder, Fibroin and Sericin from Three Thai Silkworm (Bombyx mori Linn.) in Streptozotocin-Induced Diabetic Rats}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {May 2017}, pages = {559-564}, type = {Original Article}, chapter = {559}, abstract = {

Objective: The present study was aimed to investigate the antihyperglycemic activities of Thai silkworm (Bombyx mori Linn.) powder, fibroin and sericin from three races of Thai silkworm including Nangnoi, Nanglai, and Samrong in streptozotocin-induced diabetic rats. Materials and Methods: All rats were daily and orally administered with silkworm powder (5th-instar, 3rd-day), fibroin, and sericin at a dose of 250 mg/kg for 6 weeks. After that, various parameters including body weight, blood glucose, hematological and biochemical parameters were determined. Results: The results revealed that fasting plasma glucose level in 6th week of Nanglai fibroin, Nangnoi fibroin and Nangnoi sericin expressed a better reduction of FPG in diabetic rats compared with diabetic control groups (p\<0.05). All hematological parameters of each group were not different within those values (p\>0.05). In case of blood urea nitrogen, creatinine and alkaline phosphatase value showed that some of treated groups was different from diabetic control (p\<0.05), while all of treated groups showed different in cholesterol and high density lipoprotein value (p\<0.05). Conclusion: Silkworm powders, fibroin and sericin of three races exhibited a therapeutic potential for the reduction plasma glucose level. Treatments of silkworm powder, fibroin and sericin did not have any effect on hematological parameters. Improvement of blood urea nitrogen, creatinine, alkaline phosphatase values and lipid profiles also were also observed in the treatment groups.

}, keywords = {Antihyperglycemic effect, Diabetic rats, Fibroin., Sericin, Silkworm}, doi = {10.5530/pj.2017.4.89}, url = {/files/PJ-9-4/10.5530pj.2017.4.89}, author = {Surapong Rattana and Teeraporn Katisart and Chirapha Butiman and Bunleu Sungthong} }