@article {927, title = {Antihyperlipidemic Activity of Murraya koenigii Leaves Methanolic and Aqueous Extracts on Serum Lipid Profile of High Fat-Fructose Fed Rats}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {July 2019}, pages = {836-841}, type = {Original Article}, chapter = {836}, abstract = {

Background: Dyslipidemia has been considered as one of coronary risk factors contributing to the cardiovascular diseases. The beneficial effects of Murraya koenigii leaf on HFFD induced hyperlipidemia in rats has been very less reported in the recent review of literature. Aim and Objectives: To study the hypolipidemic activity of Murraya koenigii leaves on the serum lipid profile in HFFD rat model. Material and Methods: Thirty-six rats of either sex were randomly divided into six groups of six animals each. HFFD was fed p.o to all rats from Groups I, II, IV, V and VI except Group III throughout the period of 14 weeks. Group III rats received normal diet and water ad libitum only. Group I, II, IV and V were treated respectively with AEMK (200 mg/kg/day, p. o), MEMK (200 mg/kg/day, p. o), MET (50 mg/kg/day, p. o) and ATO (10 mg/kg/day, p. o). On the last day of experimental study, blood was collected by retro-orbital puncture method. BSL and lipid profile were assessed. Results: Elevated levels of TC, TG, LDL-C, VLDL-C and diminished level of HDL-C were observed in group VI. Murraya koenigii leaves extract exhibited significant hypolipidemic effect on serum TC and LDL-C in rats owing to its hypocholesterolemic properties. AIP was highly significant in both of AEMK and MEMK extracts. Conclusion: Results of the present study have suggested that the antihyperlipidemic activity of Murraya koenigii leaves leading to decrease in serum lipid parameters mainly TC, LDL-C along with atherogenic risk might be due to its presence of bioactive compounds.

}, keywords = {Atherogenic index, High fat-fructose diet, Hyperlipidemia, lipid profile, Murraya Koenigii}, doi = {10.5530/pj.2019.11.134}, author = {Rohan S. Phatak and Chitra C. Khanwelkar and Somnath M. Matule and Kailas D. Datkhile and Anup S. Hendre} } @article {870, title = {Effect of Porana paniculata Whole Plant on Blood Glucose Levels and Lipid Profile of STZ Induced Diabetic Rats}, journal = {Pharmacognosy Journal}, year = {2019}, month = {March 2019}, pages = {xx-xx}, type = {Original Article}, chapter = {xx}, abstract = {

Background: To establish the antidiabetic potential of Porana paniculata whole plant belongs to Convolvulaceae family. Methods: Extraction and preliminary phytochemical screening were conducted by standard methods. Antidiabetic activity was evaluated by streptozotocin induced diabetic rats where the hydroalcoholic extract of plant was administered orally at a dose of 250 and 500 mg/kg for 30 days. Blood glucose levels were estimated at 1st, 10th, 20th and 30th day of study. Lipid profile was studied 30th day of study and body weight of the animals was measured at day 1 and 30. Results: Plant extract significantly (p\<0.01) reduced the blood glucose levels at both the tested dose levels of 250 and 500 mg/kg. The lipid profile was estimated in which the plant extract showed significant improved in both tested dose level that is 250 and 500 mg/kg. The body weight of the animals under study was also estimated on day 1 and 30 in which a good control was observed by the plant extract. Conclusion: Antidiabetic activity of Porana paniculata whole plant extract may be due to the presence of various phytoconstituents. Present study gives a scientific evidence for the folklore claim of the plant under study for its use in diabetes.

}, keywords = {Diabetes, Folklore, lipid profile, Porana paniculata, Streptozotocin}, doi = {10.5530/pj.2019.11.xx}, author = {Sanjeeva Kumar A and Raveendra Reddy Juturu and Rama Mohan Gupta Vankadari} } @article {838, title = {Effect of Porana paniculata Whole Plant on Blood Glucose Levels and Lipid Profile of STZ Induced Diabetic Rats}, journal = {Pharmacognosy Journal}, year = {2019}, month = {March 2019}, pages = {xx-xx}, type = {Original Article}, chapter = {xx}, abstract = {

Background: To establish the antidiabetic potential of Porana paniculata whole plant belongs to Convolvulaceae family. Methods: Extraction and preliminary phytochemical screening were conducted by standard methods. Antidiabetic activity was evaluated by streptozotocin induced diabetic rats where the hydroalcoholic extract of plant was administered orally at a dose of 250 and 500 mg/kg for 30 days. Blood glucose levels were estimated at 1st, 10th, 20th and 30th day of study. Lipid profile was studied 30th day of study and body weight of the animals was measured at day 1 and 30. Results: Plant extract significantly (p\<0.01) reduced the blood glucose levels at both the tested dose levels of 250 and 500 mg/kg. The lipid profile was estimated in which the plant extract showed significant improved in both tested dose level that is 250 and 500 mg/kg. The body weight of the animals under study was also estimated on day 1 and 30 in which a good control was observed by the plant extract. Conclusion: Antidiabetic activity of Porana paniculata whole plant extract may be due to the presence of various phytoconstituents. Present study gives a scientific evidence for the folklore claim of the plant under study for its use in diabetes.

}, keywords = {Diabetes, Folklore, lipid profile, Porana paniculata, Streptozotocin}, doi = {10.5530/pj.2017.4.x} } @article {356, title = {Acute and Sub-acute Toxicities of Thai Silkworm Powder (Bombyx mori Linn.) From Three Races in Male Wistar Rats and In vitro Antioxidant Activities}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {May 2017}, pages = {541-545}, type = {Original Article}, chapter = {541}, abstract = {

Background: The silkworm powder from Japanese and Korean races has a high biological activity. However, there was less scientific evidence regarding bioactivities in Thai silkworm races. Objective: This research was interested in toxicity and antioxidant activities of Thai silkworm races. Material and methods: The 5th instar, 3rd day of growth stage of Thai traditional silkworm (Nanglai, Nangnoi and Samrong races) were lyophilized by freeze dryer and ground as silkworm powder. The acute and sub-acute toxicities studies were carried out in male Wistar rats. The antioxidant capacities of silkworm powder were investigated with DPPH, ABTS and FRAP methods. Results: The acute toxicity in rats by single dose oral administration show that the high dose at a concentration of 2,000 mg/kg b.w. did not have toxicity in rats. The sub-acute toxicity in rats by oral administration showed that the high dose concentration at 2,000 mg/kg body weight for 6 weeks had no toxicity in all group either. In addition, the hematological parameters and lipid profiles of treated group and control groups were not significantly different. The antioxidant study showed that silkworm powders were not significant difference in all groups of samples in three assays (DPPH, ABTS and FRAP). However, significant difference had been found in comparison to ascorbic acid (p \< 0.05). Conclusion: Silkworm powder from three races of Thai silkworm did not produce any toxicity in male rats. In addition, the silkworm powder also exhibited antioxidant activities.

}, keywords = {antioxidant activities., hematological parameters, lipid profile, Silkworm, toxicities}, doi = {10.5530/pj.2017.4.87}, url = {/files/PJ-9-4/10.5530pj.2017.4.87}, author = {Surapong Rattana and Teeraporn Katisart and Bunleu Sungthong and Chirapha Butiman} } @article {1497, title = {Role of Boswellia ovalifoliolata Bal. Henry extract on high fat diet induced hypercholesterolemia}, journal = {Pharmacognosy journal}, volume = {6}, year = {2014}, month = {8th April 2014}, pages = {108-116}, type = {Original Article}, abstract = {

Objective: To evaluate the Antihypercholesterolemic effect of Boswellia ovalifoliolata Bal. Henry extract by performing in vivo studies and to check out its effects by evaluating parameters like food consumption, weight gain, fecal fat excretion, serum and liver lipid \&biochemical profiles. Even the study includes confirmation of activity by the histopathological studies. Methods: Animals were fed with cholesterol rich high fat diet. Food intake, Body weight and fecal fat excretion were measured. Serum and liver samples were analyzed for the estimation of lipid profiles and other biochemical parameters by using different kits. Histopathological study on liver, aorta, heart and adipose tissue was done to ensure the activity. Results: The animal group administered with methanolic extract of the plant has shown decreased levels of TC, LDL, VLDL, TG, HDL+VLDL, VLDL+LDL, LDL/TC, AI, SGOT, SGPT and elevated levels of HDL, HDL/TC in a dose dependent manner significantly (p\<0.01 \& p\<0.05). The evaluation of liver tissue of animal groups treated with herbal extract and standard had shown increased levels of SOD, GSH and Catalase, whereas levels of SGOT, SGPT, Total glucose, HMG-CoA, lipase, amylase and percentage of monaldehyde were decreased when compared with high fat diet fed rats. Body weight and Food intake in treated groups were significantly lower than that in model control. Conclusion: It can be confered from the present studies that the Boswellia ovalifoliolata Bal. Henry extract have strong activity against hypercholesterolemia and obesity suggesting a potential benefit as antihypercholesterolemic agent.

key words: Boswellia ovalifoliolata Bal. Henry, High fat diet, Lipid profile, Histopathological studies.

}, keywords = {Boswellia Ovalifoliolata Bal. Henry, High Fat Diet, lipid profile}, author = {D. Sathis Kumar, and David Banji, and A. Harani, and Ch. Pavan Kumar, and JN. Ravi Varma} }