@article {576, title = {Estrogenic Effects of Euphorbia hirta L. Extract in Ovariectomized Rats}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {March 2018}, pages = {435-438.}, type = {Original Article}, chapter = {435}, abstract = {

Context: Euphorbia hirta L. has been wildly used for its health benefits. It has been used as a decoction and to treat diarrhea, peptic ulcers, menstrual problems and venereal diseases. Aims: The study aims to investigate the estrogenic effects of E. hirta on ovariectomized (OVX) rats. Methods: The ovariectomized rats were divided into four groups, including those that received the vehicle (1\% v/v Tween 80, p.o.), 17\β-estradiol at a dose of 0.01 mg/kg B.W. and the ethanolic extract of E. hirta at the doses of 100 and 500 mg/kg B.W. These were administered daily for 14 days. Estrogenic activity was determined by analyzing the body, vaginal and uterine weight as well as the uterine and vaginal histopathology characteristics of the estrogen-induced response. Results: At the dose of 500 mg/kg B.W., the plant extract produced a significant increase in vaginal weight when compared with the ovariectomized rats, a slightly increase in the uterine weight and could induce hyperplastic epithelium and endometrial thickness of the vagina. Conclusion: The data in this work suggests that the plant crude extract showed weak estrogenic effects in ovariectomized rats and could be useful for health benefits for vagina atrophy of females during the menopause.

}, keywords = {Estrogenic, Euphorbia hirta L, Ovariectomized rats, Uterus, Vagina.}, doi = {10.5530/pj.2018.3.71}, url = {http://fulltxt.org/article/504}, author = {Wilawan Promprom and Wannachai Chatan} } @article {333, title = {Anti-hyperglycemic and Anti-hyperlipidemic Effects of Extract from Houttuynia cordata Thumb. in Streptozotocin-Induced Diabetic Rats}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {April 2017 }, pages = {382-387}, type = {Original Article}, chapter = {382}, abstract = {

Aim: Various properties of Houttuynia cordata Thumb. has been reported. However, few studies on its pharmacological effects have been documented. To elucidate whether there are more pharmacological effects of this plant, this study was therefore, carried out to determine the anti-hyperglycemic and anti-hyperlipidemic effects of 80\% ethanol extract of H. cordata (HCE). Their antioxidant activity and acute toxicity were also conducted. Methods: HCE at a dose of 250 mg/kg was oral given to Streptozotocin-induced diabetic rats daily for 8 weeks. DPPH assay and HCE at the doses of 1,000, 2,000 and 3,000 mg/kg were employed in antioxidant and acute toxicity studies. Results: HCE lowered FBG in the diabetic, but not in the normal treated rats. HCE did not affect the body weight of all rats, but recovered TP, Alb, Glob, BUN, CREA, UA, TB, AST, ALT, ALP, and reduced the elevated CHO, TG and LDL in the diabetic rats. HCE possessed relatively low antioxidant activity with IC50 of 115.98\± 0.82 \μg/mL compared to Vitamin C (42.54+1.37 \μg/ml), but did not produce any symptoms of acute toxicity. Conclusions: The extract of H. cordata may have beneficial properties and is a new agent for diabetic treatment and improve renal and hepatic functions.

}, keywords = {Acute toxicity, Anti-Hyperglycemic, Anti-Hyperlipidemic, Antioxidant, Houttuynia cordata Thumb}, doi = {10.5530/pj.2017.3.65}, url = {/files/PJ-9-3/10.5530pj.2017.3.65}, author = {Patcharee Poolsil and Wilawan Promprom and Chusri Talubmook} } @article {376, title = {GC-MS Analysis and Antioxidant Activity of Bauhinia nakhonphanomensis Leaf Ethanolic Extract}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {July 2017}, pages = {663-667}, type = {Original Article}, chapter = {663}, abstract = {

Context: Bauhinia nakhonphanomensis Chatan. A new species that is endemic to Thailand. Aims: Leaves of B. nakhonphanomensis were extracted and the extract was used in gas chromatography-mass spectrometry (GC-MS) analysis to evaluate the total phenols, total flavonoids and antioxidant activity. Methods: The extract of B. nakhonphanomensis was analyzed by GC-MS. Quantitative analysis for total phenols was done by the Folin-Ciocatteu method and for total flavonoids by the aluminium chloride method. The antioxidant activity of the ethanolic extract was evaluated by the DPPH method. Results: GC-MS analysis revealed the presence of 19 phytochemical constituents. These compounds were identified by comparing their retention times and peak areas with those from the literature and by interpretation of the mass spectra. The major chemical constituents were inositol (48.55 \%), alpha-tocopherol (12.21 \%) and phenol (6.61 \%). Total phenolic content was 48.69\±0.56 mg/100 of Gallic acid equivalent (GE). The total flavonoid contentwas 10539\± 6.14 mg/100 of quercetin equivalent (QE). Antioxidant activity was 17.07\±0.24 \μg/100 of ascorbic acid equivalent antioxidant capacity (AEAC).Conclusion: These findings are the first report and suggest that the rich phytochemical content of B. nakhonphanomensis has good antioxidant activity.

}, keywords = {antioxidant activity, Bauhinia Nakhonphanomensis, GC-MS, total flavonoid content, total phenolic content}, doi = {10.5530/pj.2017.5.105}, url = {/files/pj-9-5/10.5530pj.2017.5.105/index.html}, author = {Wilawan Promprom and Wannachai Chatan} }