@article {727, title = {Cholesterol-lowering Effects of Extract from Garcinia daedalanthera in Hyperlipidemic rats}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {August 2018}, pages = {1125-1128}, type = {Original Article}, chapter = {1125}, abstract = {

Background: A native plant from Indonesia, Garcinia daedalanthera has been scientifically proven have antidiabetic effects and antioxidant activity. We hypothesized that Garcinia daedalanthera can modulate the lipid profiles of hyperlipidemic rats. Objective: This study aimed to evaluate the antihyperlipidemic potential of Garcinia daedalanthera extract. Materials and Methods: Garcinia daedalanthera leaves extract (GDE) were orally administrated to high fat diet-induced rats for 15 days. After the end of experimental period (43 days) the lipid profiles were estimated along with histopathological liver examination of animals. Results: The results showed that Garcinia daedalanthera extract significantly reduced the level of serum total cholesterol, total triglycerides and low-density lipoprotein as compared to control group with an increasing level of serum high-density lipoprotein. Furthermore, the extract has a favorable effect on histopathological study. Conclusion: This study proved antilipidemic property by lowering altered levels of lipid profile in male wistar rats and suggest lipid lowering effects of Garcinia daedalanthera extract which serves as a new potential natural product for preventing hyperlipidemia.

}, keywords = {Anti-cholesterol, Garcinia, Herbal, In vivo, Pre-clinical study, Rat}, doi = {10.5530/pj.2018.6.191}, author = {Sarah Zielda Najib and Wilzar Fachri and Rani Sauriasari and Berna Elya and Raymond Tjandrawinata} } @article {255, title = {Pharmacognostic and Phytochemical Standardization of White Tea Leaf (Camellia sinensis L. Kuntze) Ethanolic Extracts}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {February 2017}, pages = {221-226}, type = {Original Article}, chapter = {221}, abstract = {

Background: Tea or also known as Camellia sinensis (Theaceae family) is the most popular plant and beverage in the world because of the sensory properties, prices are relatively cheap, stimulant effects, and their potential health benefits but white tea is not widely known. White tea is made from unfermented tea leaves young shoots protected from sunlight to avoid polyphenols degradation which inhibits of the chlorophyll formation and causing the white color on the leaf buds. Objective: The objective of research and development of herbal medicine is to improve the quality and safety of natural products. Materials and Methods: Macroscopical and microscopical features of the leaf have been analysis using an optical microscope and fragment analysis under scanning electron microscopy (SEM). Phytochemical and physico-chemical analysis were evaluated. The observation of the FTIR spectrum profiles is done by interpreting the typical peak that appears. Results: The leaf has actinocytic stomata, unicellular trichomes, heterogenous mesophyll which is characterized by the presence of calcium oxalate crystals and sclereid cells. Phytochemical analysis indicated resources the presence of tannins, flavonoids, glycosides and saponins.The content of polyphenol from white tea leaves ethanolic extract is 35.73\% with the largest concentration of catechins is 18.84\% and 17.43\% tannins. The derivative content of catechins is EGCG with 7.37\%. FTIR analysis showed functional groups of O-H, C-H, N-H, C=O, C=C, and C-O. Conclusion: Pharmacognostic and phytochemicals features established in this study may be used as part of the pharmacopoeial standard which can play an important role in its standardization.

}, keywords = {Characteristic, Macroscopic, Microscopic, Physico-chemicals, Phytochemicals, Theaceae.}, doi = {10.5530/pj.2017.2.37}, author = {Meiliza Ekayanti and Lia Ardiana and Sarah Zielda Najib and Rani Sauriasari and Berna Elya} } @article {346, title = {Preliminary Acute Oral Toxicity Study of White Tea Leaf (Camellia sinensis (L.) Kuntze) Ethanolic Extracts}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {May 2017}, pages = {479-482}, type = {Original Article}, chapter = {479}, abstract = {

Background: White tea is a kind of tea which manufactured with minimal processing only drying without fermentation process. White tea prepared from very young tea leaves or buds of Camellia sinensis (L.) Kuntze, Theaceae, covered with tiny, silvery hairs, and dried immediately after picking to prevent oxidation and commonly used as a beverage and herbal medicine. Objective: The present study was aimed to evaluate the safety of the white tea leaf ethanolic extract (WTE) with acute toxicity tests. Methods: The acute oral toxicity of WTE performed at dose 1250, 2500, and 5000 mg/Kg BW of Deutschland, Denken, and Yoken (DDY) mice. The animals observation for any mortality, behavioral, body weight and feed-water consumption pattern during the 14- day study. The liver, kidney, and heart isolation performed on day-15 to observe macroscopic and relative organ weight (ROW). Results: No treatment-related toxic symptom or mortality observed for the first 4 hours and 24 hours after oral administration of WTE at a dose of 1250, 2500, and 5000 mg/kg BW. All the groups of mice did not show the significant changes in behavior, breathing, and motoric activity. Conclusions: This studies showed that the oral LD50 of WTE was greater than 5000 mg/kg BW and suggests that the WTE is practically non-toxic in a single dose of level 5000 mg/kg BW.

}, keywords = {Acute toxicity, Camellia Sinensis (L.) Kuntze, Safety, Teh Putih, Theaceae}, doi = {10.5530/pj.2017.4.77}, url = {/files/PJ-9-4/10.5530pj.2017.4.77}, author = {Lia Ardiana and Meiliza Ekayanti and Sarah Zielda Najib and Rani Sauriasari and Berna Elya} }