@article {492, title = {Antidiabetic Activity Studies of White Tea (Camellia sinensis (L.) O. Kuntze) Ethanolic Extracts in Streptozotocin-nicotinamide Induced Diabetic Rats}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {December 2017}, pages = {186-189}, type = {Original Article}, chapter = {186}, abstract = {

Background: The high polyphenol content of white tea exhibits antiseptic and antioxidant properties that can prevent free radicals, inhibit oxidative stress and inflammation associated with various diseases such as obesity, diabetes and other degenerative diseases. Oral administration of white tea ethanolic extract (WTE) is expected to use as an alternative in the treatment of diabetes mellitus. Objective: This study aims to evaluate the effect of WTE on reducing fasting blood glucose levels in diabetic rats. Methods: Antidiabetic activity study of white tea extract performed on diabetic Sprague-Dawley male rats induced streptozotocin-nicotinamide for 14 days of oral administration. The antidiabetic effect compared to normal control, diabetic control, and standard control groups. Results: The administration of WTE for 14 days showed decreased fasting blood glucose level in diabetic rats. The dose of 100 mg/kg BW of WTE has the highest effect on reducing fasting glucose level significantly compared to negative control group (p\<0.05). The content of flavonoids, especially catechin compounds are suspected to play a role in lowering fasting blood glucose levels. Conclusion: The administration of WTE for 14 days has potentially antidiabetic activity in diabetic rats induced streptozotocin-nicotinamide.

}, keywords = {Antidiabetic, Camellia sinensis, Catechin, Hypoglycemic, Streptozotocin, White tea}, doi = {10.5530/pj.2018.1.31}, url = {http://fulltxt.org/article/417}, author = {Lia Ardiana and Rani Sauriasari and Berna Elya} } @article {255, title = {Pharmacognostic and Phytochemical Standardization of White Tea Leaf (Camellia sinensis L. Kuntze) Ethanolic Extracts}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {February 2017}, pages = {221-226}, type = {Original Article}, chapter = {221}, abstract = {

Background: Tea or also known as Camellia sinensis (Theaceae family) is the most popular plant and beverage in the world because of the sensory properties, prices are relatively cheap, stimulant effects, and their potential health benefits but white tea is not widely known. White tea is made from unfermented tea leaves young shoots protected from sunlight to avoid polyphenols degradation which inhibits of the chlorophyll formation and causing the white color on the leaf buds. Objective: The objective of research and development of herbal medicine is to improve the quality and safety of natural products. Materials and Methods: Macroscopical and microscopical features of the leaf have been analysis using an optical microscope and fragment analysis under scanning electron microscopy (SEM). Phytochemical and physico-chemical analysis were evaluated. The observation of the FTIR spectrum profiles is done by interpreting the typical peak that appears. Results: The leaf has actinocytic stomata, unicellular trichomes, heterogenous mesophyll which is characterized by the presence of calcium oxalate crystals and sclereid cells. Phytochemical analysis indicated resources the presence of tannins, flavonoids, glycosides and saponins.The content of polyphenol from white tea leaves ethanolic extract is 35.73\% with the largest concentration of catechins is 18.84\% and 17.43\% tannins. The derivative content of catechins is EGCG with 7.37\%. FTIR analysis showed functional groups of O-H, C-H, N-H, C=O, C=C, and C-O. Conclusion: Pharmacognostic and phytochemicals features established in this study may be used as part of the pharmacopoeial standard which can play an important role in its standardization.

}, keywords = {Characteristic, Macroscopic, Microscopic, Physico-chemicals, Phytochemicals, Theaceae.}, doi = {10.5530/pj.2017.2.37}, author = {Meiliza Ekayanti and Lia Ardiana and Sarah Zielda Najib and Rani Sauriasari and Berna Elya} } @article {346, title = {Preliminary Acute Oral Toxicity Study of White Tea Leaf (Camellia sinensis (L.) Kuntze) Ethanolic Extracts}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {May 2017}, pages = {479-482}, type = {Original Article}, chapter = {479}, abstract = {

Background: White tea is a kind of tea which manufactured with minimal processing only drying without fermentation process. White tea prepared from very young tea leaves or buds of Camellia sinensis (L.) Kuntze, Theaceae, covered with tiny, silvery hairs, and dried immediately after picking to prevent oxidation and commonly used as a beverage and herbal medicine. Objective: The present study was aimed to evaluate the safety of the white tea leaf ethanolic extract (WTE) with acute toxicity tests. Methods: The acute oral toxicity of WTE performed at dose 1250, 2500, and 5000 mg/Kg BW of Deutschland, Denken, and Yoken (DDY) mice. The animals observation for any mortality, behavioral, body weight and feed-water consumption pattern during the 14- day study. The liver, kidney, and heart isolation performed on day-15 to observe macroscopic and relative organ weight (ROW). Results: No treatment-related toxic symptom or mortality observed for the first 4 hours and 24 hours after oral administration of WTE at a dose of 1250, 2500, and 5000 mg/kg BW. All the groups of mice did not show the significant changes in behavior, breathing, and motoric activity. Conclusions: This studies showed that the oral LD50 of WTE was greater than 5000 mg/kg BW and suggests that the WTE is practically non-toxic in a single dose of level 5000 mg/kg BW.

}, keywords = {Acute toxicity, Camellia Sinensis (L.) Kuntze, Safety, Teh Putih, Theaceae}, doi = {10.5530/pj.2017.4.77}, url = {/files/PJ-9-4/10.5530pj.2017.4.77}, author = {Lia Ardiana and Meiliza Ekayanti and Sarah Zielda Najib and Rani Sauriasari and Berna Elya} }