@article {726, title = {Sterols from Lentinus tigrinus}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {August 2018}, pages = {1079-1081}, type = {Original Article}, chapter = {1079}, abstract = {

Aim: To investigate the chemical constituents of the dichloromethane extract of the fruiting bodies of the mushroom Lentinus tigrinus. Materials and Methods: The chemical constituents of L. tigrinus were isolated by silica gel chromatography, while the chemical structures of the isolated compounds were identified by NMR spectroscopy. Results: The dichloromethane extract of the fruiting bodies of L. tigrinus afforded cerevisterol (1), and a mixture of stellasterol (2) and ergosterol (3) in about 4:5 ratio. Conclusion: To the best of our knowledge, this is the first report on the isolation of 1-3 from the fruiting bodies of L. tigrinus.

}, keywords = {Cerevisterol, Ergosterol, Lentinus tigrinus, Polyporaceae, Stellasterol}, doi = {10.5530/pj.2018.6.182}, author = {Consolacion Y. Ragasa and Maria Carmen S. Tan and Ma. Ellenita De Castro and Mariquit M. De Los Reyes and Glenn G. Oyong and Chien-Chang Shen} } @article {751, title = {A Triterpene and a Depside from Parmotrema austrocetratum Elix and J. Johnst.}, journal = {Pharmacognosy Journal}, volume = {10}, year = {2018}, month = {November 2018}, pages = {s27-s29}, type = {Original Article}, chapter = {s27}, abstract = {

Introduction: Parmotrema austrocetratum Elix and J. Johnst. (syn. Rimelia austrocetrata Elix and J. Johnst.) which belongs to a large genus of lichenized fungi, Parmotrema Massalongo under family Parmeliaceae was investigated for its chemical constituents. Methods: The compounds were isolated by silica gel chromatography and their chemical structures were elucidated by NMR spectroscopy. Results: Chemical investigation of the dichloromethane extract of Parmotrema austrocetratum Elix and J. Johnst. has led to the isolation of zeorin (1) and atranorin (2). Conclusion: P. austrocetratum shares similar chemical characteristic with other Parmotrema species which afforded atranorin. This work highlights the first reported isolation of 1 from P. austrocetratum and the genus Parmotrema.

}, keywords = {Atranorin, Parmeliaceae, Parmotrema austrocetratum, Rimelia austrocetrata, Zeorin}, doi = {10.5530/pj.2018.6s.4}, author = {Consolacion Y. Ragasa and Maria Carmen S. Tan and Virgilio C. Linis and Chien-Chang Shen} } @article {374, title = {Chemical Constituents of Dracontomelon Dao (Blanco) Merr. et Rolfe}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {July 2017}, pages = {654-656}, type = {Original Article}, chapter = {654}, abstract = {

Introduction: The leaves, twigs and flowers of Dracontomelon dao (Blanco) Merr. et Rolfe, an indigenous Philippine tree were investigated for their chemical constituents. Methods: The compounds were isolated by silica gel chromatography and their structures were identified by NMR spectroscopy. Results: Chemical investigation of D. dao led to the isolation of cardol (1), \β-sitosteryl-3\β-glucopyranoside-6, O-fatty acid esters (2), \β-sitosteryl fatty acid esters (3), and a mixture of \β-sitosterol (4a) and stigmasterol (4b) from the petiole; 1, a mixture of 4a and 4b, anacardic acid (5), triacylglycerols (6), monoacylglycerol (7), long-chain fatty acid esters (8), and linoleic acid (9) from the twigs; and a mixture of 4a and 4b, 5, 6, 8, long-chain fatty alcohols (10), and long- chain hydrocatbons (11) from the flowers of D. dao.The structures of 1 and 5 were elucidated by extensive 1D and 2D NMR spectroscopy, while those of 2-4 and 6-11 were identified by NMR spectroscopy. Conclusion: This is the first report on the isolation of 1, 4b and 6-9 from D. dao.

}, keywords = {3-Alkylphenols, Anacardaceae, Anacardic Acid, B-Sitosteryl Fatty Acid Esters, B-Sitosteryl-3β-Glucopyranoside-6{\textquoteright}-O-Fatty Acid Esters, Cardol, Dracontomelon dao (Blanco) merr. Et Rolfe}, doi = {10.5530/pj.2017.5.103}, url = {/files/pj-9-5/10.5530pj.2017.5.103/index.html}, author = {Consolacion Y. Ragasa and Tyson C. Batarra and Julius Leonard A. Vivar and Mariquit M. De Los Reyes and Chien-Chang Shen} } @article {218, title = {Cytotoxic Compounds from Kibatalia gitingensis (Elm.) Woodson}, journal = {Pharmacognosy Journal}, volume = {9}, year = {2017}, month = {December 2016}, pages = {8-13}, type = {Original Article}, chapter = {8}, abstract = {

Ursolic acid (1), squalene (2), a mixture of \α-amyrin acetate (3a) and lupeol acetate (3b), and isoscopoletin (4), isolated from the dichloromethane extracts of the leaves and twigs of Kibatalia gitingensis, were evaluated for their cytotoxic activities against three human cancer cell lines, breast (MCF-7) and colon (HT-29 and HCT-116), and a normal cell line, human dermal fibroblast-neonatal (HDFn), using the in vitro PrestoBlue cell viability assay. Compounds 1-4 exhibited strong cytotoxic activities against HT-29 cells with IC50 values ranging from 0.6931 to 1.083 \μg/mL. Furthermore, 1-4 were moderately cytotoxic against HCT-116 cells with IC50 values ranging from 4.065 to 11.09 \μg/mL. These compounds were least cytotoxic against MCF-7 cells with IC50 values ranging from 8.642 to 25.87 \μg/mL. The most cytotoxic against HT-29 cells, HCT-116 cells and MCF-7 cells are 2, 4 and 1, respectively.

}, keywords = {Apocynaceae, Cytotoxicity, HCT-116, HDFn, HT-29, Isoscopoletin, Kibatalia gitingensis, Lupeol acetate, MCF-7, PrestoBlue{\textregistered} cell viability assay., Squalene, Ursolic acid, α-amyrin acetate}, doi = {10.5530/pj.2017.1.2}, author = {Mariquit M. De Los Reyes and Glenn G. Oyong and Vincent Antonio S. Ng and Chien-Chang Shen and Consolacion Y. Ragasa} }