@article {2598, title = {The Effectiveness of Enteral Administration of Binahong Leaf Extract (Anredera cordifolia (Tenore) Steenis) on Blood Glucose Levels, MDA, and NGF in Wistar Rats with Diabetic Neuropathy Model}, journal = {Pharmacognosy Journal}, volume = {18}, year = {2026}, month = {June 2026}, pages = {107-112}, type = {Original Article}, chapter = {107}, abstract = {

Background: Chronic hyperglycemia causes oxidative stress in the peripheral nervous system, which leads to the development of diabetic neuropathy. Free radicals initiate lipid peroxidation of membranes and produce malondialdehyde (MDA). Reduced Nerve Growth Factor (NGF) in diabetes indicates significant neuronal abnormalities. Binahong (Anredera cordifolia (Ten.) Steenis) belongs to the Basellaceae family and possesses therapeutic effects, making it a promising herbal remedy for the development of treatments for diabetic neuropathy. Objective: To determine the effectiveness of binahong leaf extract (Anredera cordifolia (Tenore) Steenis) in lowering blood sugar and MDA levels and increasing NGF in Wistar rats with diabetic neuropathy. Methods: This study was an experimental study using rats with a randomized control trial with a post-test control only design. The study population consisted of 36 Wistar rats divided into 6 groups randomly, which were then induced with diabetic neuropathy via streptozotocin injection at 65 mg/kg. Complete data collection was conducted, followed by blood glucose levels, MDA, and NGF measurements, and data analysis. Results: There were significant differences (p\<0.05) in blood glucose levels, MDA, and NGF between the normal group, the 50 mg/kg binahong leaf extract group, the 100 mg/ kg radish extract group, and the 200 mg/kg group compared to the negative control group. This indicates that binahong leaf extract, starting at a dose of 50 mg/kg, can reduce blood glucose levels and MDA while increasing NGF. Conclusion: Binahong leaf extract (Anredera cordifolia (Tenore) Steenis) is effective in lowering blood glucose levels and MDA levels while increasing NGF in a rat model of diabetic neuropathy.

}, keywords = {Anredera cordifolia, blood glucose levels, Diabetic neuropathy, Malondialdehyde, Nerve Growth Factor, Wistar Rats}, doi = {10.5530/pj.2026.18.123}, author = {Ana Fresia and Gusbakti Rusip and Ade Indra Mukti and Ali Napiah Nasution} } @article {2463, title = {Comparison of the Effectiveness of Cream Extracts and VEGF Expression on Incision Wounds in Male Wistar Rats Treated with Ethanol Extracts of Papaya Leaf, Fruit Flesh, and Seeds (Carica Papaya L.)}, journal = {Pharmacognosy Journal}, volume = {17}, year = {2025}, month = {January 2025}, pages = {28-39}, type = {Original Article}, chapter = {28}, abstract = {

Background: Papaya (Carica papaya Linn) is a tropical fruit plant known for its medicinal benefits, including wound healing. Objective: This study aimed to analyze and compare the potential of papaya leaf, fruit, and seed extracts in accelerating incision wound healing in male Wistar rats. Additionally, we compared the flavonoid content and stability of the extracts in cream formulations. Materials and Methods: Creams containing 30\% ethanol extracts of papaya leaf, fruit, and seeds were prepared and applied to the backs of male Wistar rats for two weeks. The wound diameter, epithelial thickness, fibroblast count, macrophage count, collagen density, and VEGF expression were measured after two weeks. Results: Our findings revealed no significant differences between the effects of the papaya leaf, fruit, and seed ethanol extracts on wound diameter, epithelial thickness, fibroblast count, macrophage count, and collagen density (p \> 0.05). There were also no significant differences when compared to the negative control group (p \> 0.05). The highest flavonoid content was found in the ethanol extract of papaya leaves. Application of the ethanol extract creams of leaf, fruit, and seeds had a significant effect on angiogenesis, as evidenced by VEGF expression (p = 0.002). Conclusion: Papaya leaf, fruit, and seed extracts are promising products for wound healing. Further research is recommended to conduct periodic histopathological examinations during the wound healing process and to explore different extract concentrations for optimal results.

}, keywords = {Incision wound; Male Wistar rats; Papaya; VEGF}, doi = {10.5530/pj.2025.17.4}, author = {Ali Napiah Nasution and Juanto Tiojaya and Stephanie and Erny Tandanu and Suandy Suandy and Andre Budi and Masdalena Nasution} } @article {2564, title = {Hepatoprotective Potential of Coffea arabica Extract Against Carbon Tetrachloride Induced Liver Damage: Ultrasonographic and Cytokine Evaluation}, journal = {Pharmacognosy Journal}, volume = {17}, year = {2025}, month = {December 2025}, pages = {742-750}, type = {Original Article}, chapter = {742}, abstract = {

Carbon tetrachloride (CCl$_{4}$) is a hepatotoxic agent widely used to model liver injury in experimental animals, and coffee (Coffea arabica) extract is known to contain various bioactive compounds with antioxidant and anti-inflammatory potential. This study aimed to evaluate the hepatoprotective activity of Coffea arabica extract in male Wistar rats induced with CCl$_{4}$ through phytochemical analysis, liver biochemical parameters (albumin, bilirubin, SGOT, SGPT), inflammatory cytokines (TNF-α, IL-6, CRP), and liver morphology observations using ultrasonography and histopathology. The extract contained alkaloids, flavonoids, triterpenoids, saponins, and glycosides, with total phenolic and flavonoid contents of 51.32 mg GAE/g and 1.25 mg QE/g extract, respectively, and moderate antioxidant activity (IC$_{5}$$_{0}$ = 124.36 ppm). Administration of the extract at 300 mg/kg BW significantly improved liver structure, reduced TNF-α (120.62 {\textpm} 21.78 pg/mL), IL-6 (68 {\textpm} 14.44 pg/mL), CRP (199.0 {\textpm} 41.5 pg/mL), SGOT (147.0 {\textpm} 34.28 g/dL), and SGPT (69.6 {\textpm} 9.94 g/dL) levels, while increasing albumin (2.94 {\textpm} 0.34 g/dL) and reducing bilirubin (0.09 {\textpm} 0.04 mg/dL), approaching normal conditions. The 300 mg/kg BW dose showed the most optimal protective effect compared to other treatment groups, as evidenced by improvements in biochemical parameters, liver morphology, and hepatic histology, indicating that Coffea arabica extract has strong potential as an effective hepatoprotective agent against CCl$_{4}$-induced liver damage

}, keywords = {CCl$_{4}$, Coffea arabica, Cytokines, Hepatotoxicity, liver protection, Ultrasonographic}, doi = {10.5530/pj.2025.17.93}, author = {Desi Novianti and I Nyoman Ehrich Lister and Ali Napiah Nasution} }