@article {2299, title = {Effect of Propofol TIVA Compared Sevoflurane Inhalation Anesthesia on Triglyceride Levels After Elective Craniotomy Surgery}, journal = {Pharmacognosy Journal}, volume = {16}, year = {2024}, month = {June 2024}, pages = {597-601}, type = {Research Article}, chapter = {597}, abstract = {

Background: Propofol TIVA has been shown to be more effective than sevoflurane in craniotomy surgery. Propofol TIVA offers the benefit of giving better brain relaxation during surgery while also being less expensive than sevoflurane. Nonetheless, it is important to highlight that propofol has side effects that should be considered. Large doses and prolonged anesthesia may result in increased triglycerides (lipids) as well as Propofol Infusion Syndrome (PRIS). As part of their investigation into the detrimental effects of propofol, researchers discovered the necessity for controls to avoid confusing the effects of the surgery itself. Therefore, sevoflurane was chosen as the control group to comprehend and analyze the effects of propofol more accurately. Methods: A prospective observational study analysis was conducted on elective craniotomy patients at RSUD Dr. Soetomo from November to December 2023. 52 subjects were divided into two groups, namely the TIVA Propofol and Sevoflurane Inhalation groups. Each group will be examined for preoperative triglyceride levels and postoperative triglyceride levels while already in the ICU. Results: Postoperative triglyceride levels in the Propofol TIVA group were significantly higher. In the comparison test between the two anesthesia methods on triglyceride levels, there was a significant effect in the Propofol TIVA group. In the test of the relationship between the duration of anesthesia in both groups, there was no significant relationship. In the test of the relationship between the total dose of propofol and triglyceride levels, it was found that the greater the dose of propofol used, the higher the increase in triglyceride levels. In the test of the relationship between the total amount of sevoflurane and triglyceride levels, it was found that the greater the dose of sevoflurane used, the greater the decrease in triglyceride levels, which was statistically not significant. Conclusion: TIVA Propofol increases triglyceride levels compared to sevoflurane inhalation in patients undergoing elective craniotomies.

}, keywords = {Craniotomy, Sevoflurane, TIVA propofol, Triglycerides}, doi = {10.5530/pj.2024.16.93}, author = {Andika Perdani Somawi and Nancy Margarita Rehatta and Prihatma Kriswidyatomo and Kohar Hari Santoso and Hamzah and Pudji Lestari} } @article {2329, title = {Relationship Between Cerebrospinal Fluid S100B Levels with Glasgow Coma Scale and Rotterdam CT Score in Traumatic Brain Injury Patients}, journal = {Pharmacognosy Journal}, volume = {16}, year = {2024}, month = {June 2024}, pages = {503-508}, type = {Original Article}, chapter = {503}, abstract = {

Background: Traumatic brain injury (TBI) stands as one of the foremost reasons for mortality and incapacitation in young adults on a global scale, accounting for nearly half of all injury-related deaths. The severity of TBI can be assessed using various biomarkers, with the SI00B protein being one of them. While many studies have explored the correlation between serum protein levels and various aspects such as neuroimaging findings, clinical scores, and neuropsychological evaluations, there is a notable lack of research examining the correlation with cerebrospinal fluid (CSF) levels. Methods: The research design of this study was prospective and observational, employing analytic methods for analysis. Fifteen TBI patients who met the inclusion and exclusion criteria and were fitted with ICP monitors comprised the study sample. GCS data used is post-resuscitation GCS. Data on SIOOB protein levels were taken from the examination of CSF samples taken when the ICP monitor was installed. Rotterdam CT score variables was taken from the last CT scan performed before the patient was fitted with an ICP monitor. The statistical analysis was conducted utilizing the SPSS version 26 software. Results: Demographic characteristics for this study tended to be more male (73.3\%), with ages ranging from 18 to 65 years, and a mean age of 34.60 {\textpm} 16.22 years. The majority of injury mechanisms were traffic accidents (80\%), and the most common lesion type was ICH. The mean CSF S 100B value of the 15 samples was 2753.689 pg/ ml. The results of the relationship test between S 100B CSF and GCS using the Spearman test obtained a p-value of less than 0.05, indicating a meaningful correlation between S 100B CSF and GCS, with a correlation coefficient or r value of -0.684. The results of the SIOOB CSF relationship test with Rotterdam CT Score obtained a p-value \<0.05, with a correlation coefficient or r value of 0.827. Conclusion: Increased levels of S100B in cerebrospinal fluid are associated with decreased GCS and increased Rotterdam CT score in traumatic brain injury patients.

}, keywords = {Glasgow Coma Scale, Rotterdam CT score., S100B, Traumatic Brain Injury}, doi = {10.5530/pj.2024.16.81}, author = {Rian Nofiansyah and Kohar Hari Santoso and Prananda Surya Airlangga and Prihatma Kriswidyatomo and Hamzah} } @article {2277, title = {The Role of Neuron Specific Enolase, S100B, Glial Fibrillary Acidic Protein, and Myelin Basic Protein as Prognostic and Survival Values in Traumatic Brain Injury: Systematic Review and Meta-analysis}, journal = {Pharmacognosy Journal}, volume = {16}, year = {2024}, month = {April 2024}, pages = {478-484}, type = {Review Article}, chapter = {478}, abstract = {

Background: The high number of accidents and traumatic brain injuries, especially in the productive age group, causes a lot of morbidity and mortality. A fast and accurate examination method is needed for the diagnosis and treatment of traumatic brain injury. Nerve damage biomarkers such as Neuron Specific Enolase, S100B, Glial Fibrillary Acidic Protein, and Myelin Basic Protein, have been used globally both for research and daily use to determine the severity of traumatic brain injury. Methods: Searches and journal searches were carried out from Science Direct, Scopus, Springer Link, and PubMed, with the keywords "Neuron Specific Enolase", "S100B", "Glial Fibrillary Acidic Protein", "Myelin Basic Protein", and "Traumatic Brain Injury {\textquotedblright}. Screening was carried out using PRISMA 2021 to look for studies that met the criteria and were of sufficient study quality according to the Newcastle-Ottawa Scale. Results: Twenty-three studies were collected and further grouped based on outcomes, both prognostic and survival outcomes. Neuron Specific Enolase, S100B, and Glial Fibrillary Acidic Protein values were higher in poor outcomes (all p values \< 0.001) and poor survival (all p values \< 0.001) in traumatic brain injury. Myelin Basic Protein was not significant in poor outcome (p = 0.35), but was higher in poor survival (p \< 0.001) in traumatic brain injury. Conclusion: Neuron Specific Enolase, S100B, and Glial Fibrillary Acidic Protein, can be used as markers for prognostic and survival value in traumatic brain injury. Myelin Basic Protein can be used as a marker for survival value in traumatic brain injury.

}, keywords = {Glial Fibriallary Acidic Protein, Myelin Basic Protein, Neuron Specific Enolase, Prognostic Value, S100B, Survival, Traumatic Brain Injury}, doi = {10.5530/pj.2024.16.76}, author = {Wibowo Artho Sutrisno and Prananda Surya Airlangga and Citrawati Dyah Kencono Wungu and Prihatma Kriswidyatomo and Hamzah and Bambang Pujo Semedi and Mahmudah} }