@article {2382, title = {Increasing Oxytocin through Electroacupuncture Stimulation at LI4 and SP6 Points in Postpartum Cesarean Section}, journal = {Pharmacognosy Journal}, volume = {16}, year = {2024}, month = {October 2024}, pages = {1051-1055}, type = {Original Article}, chapter = {1051}, abstract = {

Background: Pain from postoperative cesarean section stitches can cause physiological stress, thereby disrupting mobility and affecting the uterine involution process postpartum. Acupuncture at points LI4 and SP6 has been reported to stimulate uterine contractions and reduce pain. Objective: To look into how electroacupuncture (EA) stimulation works at particular places LI4, SP6, and the combination of LI4 \& SP6 with frequencies of 30, 50, and 100 Hz on the increase in oxytocin levels postpartum cesarean section. Method: The number of respondents was 144 postpartum cesarean section patients who met the inclusion criteria, divided using the randomized controlled trial (RCT) method into 8 intervention and control groups. Oxytocin levels were analyzed through blood samples using the ELISA method, comparing results before and after the intervention as well as with the control group. Result: The electroacupuncture intervention group{\textquoteright}s analysis at points LI4 and SP6 showed a substantial (P\<0.05) rise in oxytocin levels when compared to the control group. Conclusion: The findings of this research suggest that electroacupuncture intervention following a cesarean section can induce a rise in the levels of the hormone oxytocin.

}, keywords = {Electroacupuncture, LI4, Oxytocin, Postpartum, SP6}, doi = {10.5530/pj.2024.16.170}, author = {Nurul Azizah and Budi Santoso and Abdurachman and Hanik Badriyah Hidayati and Ario Imandiri and Rafhani Rosyidah and Ratna Dwi Jayanti} } @article {2314, title = {A Study is Examining How Postpartum Pain after Cesarean Section (SC) Can be Reduced by Boosting Levels of β-endorphin Through Electroacupuncture Stimulation at The Specified Points LI4 and SP6}, journal = {Pharmacognosy Journal}, volume = {16}, year = {2024}, month = {June 2024}, pages = {670-676}, type = {Research Article}, chapter = {670}, abstract = {

Background: The physical healing process following a cesarean section surgery can induce anxiety and physiological stress due to wound pain, potentially impairing patient mobility and necessitating the administration of analgesic therapy. Pharmacological treatment sometimes proves insufficient or contraindicated for postpartum cesarean section patients, highlighting the need for non-pharmacological alternative therapies. Objective: This study aims to investigate the impact of electroacupuncture (EA) stimulation at specific points SP6 and LI4 using frequencies of 30, 50, and 100 Hz on reducing pain intensity and increasing levels of the hormone β-endorphin in postpartum cesarean section patients. Method: In this research, 144 postpartum cesarean section participants meeting inclusion criteria are divided into 8 groups, comprising intervention and control groups, utilizing a randomized control trial (RCT) technique. Pain intensity is measured using the pain numeric rating scale (PNRS), while levels of β-endorphin are analyzed through blood samples using the enzyme-linked immunosorbent assay (ELISA) method to compare outcomes before and after intervention. Result: The analysis of the intervention group receiving electroacupuncture at specific points LI4 and SP6 has demonstrated effectiveness in reducing pain by increasing levels of the hormone β-endorphin, in comparison to the control group, with significant findings. Conclusion: The findings of this study show that electroacupuncture intervention in postpartum cesarean section patients can stimulate an increase in β-endorphin hormone levels and effectively reduce postpartum cesarean section pain intensity.

}, keywords = {Cesarean section, Electroacupuncture, LI4, Postpartum, SP6}, doi = {10.5530/pj.2024.16.112}, author = {Nurul Azizah and Budi Santoso and Abdurachman and Hanik Badriyah Hidayati and Ario Imandiri} } @article {2166, title = {Alteration of IL-6, BMP-15 and GDF-9 Levels on PCOS Rat Models After Treated with Syzygium Polyanthum (Wight) Walp Leaves Extract}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {December 2023}, pages = {1084-1090}, type = {Original Article}, chapter = {1084}, abstract = {

Background: Polycystic ovary syndrome (PCOS) is a global health concern for women in reproductive age women. Numerous studies have been reported an association between chronic inflammation and alteration of cytokine in women with PCOS. Syzygium polyanthum (S. polyanthum) contains antioxidants and has antiinflammation activity. Objectives: This study aims to measure the alteration of IL-6, BMP-15, and GDF-9 in rat PCOS model after treated with S. polyanthum leaves extract. Materials and Methods: The female Wistar rats were divided into five groups (n = 5), K0 (normal control), K1 (PCOS group), and three treatment groups which received three different doses of S. polyanthum leaves extract. The treatment group consisted of PCOS rat models with S. polyanthum leaves extract supplementation of 150 mg/KgBW (P1), 300 mg/KgBW (P2), and 450 mg/KgBW (P3). Results: IL-6 expression was highest in K1 (4,690 {\textpm} 0.099) and lowest in the P3 treatment, namely (2,370 {\textpm} 0.105). The expression of BMP-15 and GDF-9 was lowest at K1 (2.554 {\textpm} 0.04; 4.502 {\textpm} 0.050) and highest at P3, namely (2.265 {\textpm} 0.072; 4.736{\textpm}0.074). Conclusion: S. polyanthum leaves extract was significantly effective in decreasing IL-6 expressions, as well as a significant increase in BMP-15 and GDF-9 expressions in the PCOS rat model.

}, keywords = {BMP-15, GDF-9, IL-6, Syzygium polyanthum}, doi = {10.5530/pj.2023.15.198}, author = {Renny Aditya and Budi Santoso and Widjiati} } @article {2120, title = {The Effect of Syzygium Polyanthum (Wight) Walp. Extract on Glutathione, Tumour Necrosis Factor-Alpha, Spdl1, And Degraff Follicles Expression in PCOS Rat Models}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {October 2023}, pages = {791-800}, type = {Original Article}, chapter = {791}, abstract = {

Background: Polycystic ovary syndrome (PCOS) is an endocrine and reproductive disorder affecting 5\% to 13\% of women of reproductive age. Approximately 80\% of women with PCOS underwent infertility cases. Many studies have shown an association between PCOS and low-grade inflammation. Syzygium polyanthum (S. polyanthum) contains antioxidants and has antiinflammation activity. Objectives: This study aims to investigate the effectiveness of S. polyanthum leaf on glutathione, tumour necrosis factoralpha (TNF-α), sPDL1, and DeGraff follicle expression in PCOS rat models. Materials and Methods: The female Wistar rats were divided into five groups (n = 5), K0 (normal control), K1 (PCOS group), and three treatment groups which received three different doses of S. polyanthum extract. The treatment group consisted of PCOS rat models with S. polyanthum extract supplementation of 150 mg/KgBW (P1), 300 mg/KgBW (P2), and 450 mg/KgBW (P3). Results: S. polyanthum leaf extract significantly decreased TNF-α expression in the treatment group. The highest TNF-α, GSH, and sPDL1 concentration was found in the P3 group (3.83{\textpm}0.123, 273.12{\textpm}12.4 ng/ml, and 3.25 ng/ml, respectively). Moreover, the number of follicles was statistically significant in the P1, P2, and P3 groups (2.0, 3.0, and 3.50, respectively). The number of follicles in the P1, P2, and P3 groups was higher than in the positive control; however, it was lower in the negative control (K0) (p\<0.05). Conclusion: S. polyanthum extract was significantly effective in decreasing TNF-α expression, as well as a significant increase GSH, sPDL1 and DeGraff foliclle count in PCOS rat model.

}, keywords = {DeGraff follicle count, GSH, sPDL1, Syzygium polyanthum, TNF-.}, doi = {10.5530/pj.2023.15.154}, author = {Renny Aditya and Budi Santoso and Widjiati} }