@article {2019, title = {Development of Patient Safety Management Learning Model Based on Problem Based Learning Integrated Soft Skill Higher Level Thinking for Health Students in Samarinda}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {April 2023}, pages = {418-423}, type = {Research Article}, chapter = {418}, abstract = {

Background: Nursing students who participate in clinical practice in hospitals are not ready to provide quality care in maximizing patient safety. This study aims to develop a Problem Based Learning Patient Safety (PBLPS) conceptual model design that stimulates high-level thinking soft skills for students and finds PBLPS learning tools. Method: Research and Development (R\&D), which is a research method that aims to produce new products through a development process. The stages of the research method consist of 3 stages, namely: the preliminary study stage; model development stage; model testing stage. The research subjects were nursing students at tertiary institutions in Samarinda city who had taken patient safety management courses, totaling 162 people. Data were analyzed using the Wilcoxon test. Results: Patient safety goals have not been implemented properly by students who practice clinical practice in hospitals. Students state that case-based learning can improve both hard skills and soft skills. The design of the integrated Problem Based Learning (PBL) learning model and the integrated PBLPS learning tools developed are RPS and integrated PBL-based modules on patient safety management. The results of the analysis of the soft skills assessment of high-level thinking students who practice in hospitals in the first year and the second-year show that there are differences in the results of the assessment of high-level thinking soft skills in the application of patient safety. Conclusion: The Problem Based Learning Patient Safety (PBLPS) conceptual model can stimulate high-order thinking soft skills for students in patient safety management practices in hospitals.

}, keywords = {Patient Safety, Problem Based Learning, Soft skills.}, doi = {10.5530/pj.2023.15.65}, author = {Hilda and Supriadi and Hesti Prawita Widiastuty and Arsyawina and Anwar Mallongi} } @article {1925, title = {Differences in interleukin-6 and interleukin-17 expression in covid-19 post-mortem lung tissue biopsy compared with noncovid- 19}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {January 2023}, pages = {887-892}, type = {Original Article }, chapter = {887}, abstract = {

Background: COVID-19 has spread rapidly around the world. It is necessary to study lung tissue of postmortem COVID19 patients to determine the molecular alteration particularly the role of IL-6 and IL-17 in causing fatality. Objective: This study aims to determine the differences in the expressions of IL-6 and IL-17 in lung tissue of post-mortem COVID-19 patients compared to non-COVID-19 patients. This study also aimed to analyze the correlation between the expressions of IL-6 and IL-17 in lung tissue of post-mortem COVID-19 patients. Methods: This research is an observational analytic study with crosssectional approach. The samples were 15 paraffin blocks of post-mortem lung tissue biopsy of COVID-19 patients, and 15 paraffin blocks of inflammatory lung tissue biopsy or surgery of non-COVID-19 patients. IL-6 and IL-17 expressions were evaluated by immunohistochemical procedure. Result: There was a significant difference in the expression of IL-6 in the COVID-19 group and the non-COVID-19 group with a p-value = 0.001 (p \< 0.05). There was a significant difference in the expression of IL-17 in the COVID-19 group and the non-COVID-19 group with p-value = 0.001 (p \< 0.05). There was a significant correlation between the expressions of IL-6 and IL-17 in the COVID-19 group, with the Spearman coefficient value (rs) of 0.548 with p = 0.034 (p \< 0.05). Conclusion: There are differences in the expression of IL-6 and IL-17 between COVID-19 and non-COVID-19 lung tissue. There is a significant correlation between the expressions of IL-6 and IL-17 in post-mortem lung tissue of COVID-19 patients.

}, keywords = {Biopsy, COVID-19, IL-17, IL-6, Post mortem lung tissue.}, doi = {10.5530/pj.2022.14.184}, author = {Etty Hary Kusumastuti and Priangga Adi Wiratama and Grace Ariani and Stephanie Natasha Djuanda and Alphania Rahniayu and Nila Kurniasari and Dyah Fauziah and Anny Setijo Rahaju and Isnin Anang Marhana and Alfian Nur Rosyid and Dwi Wahyu and Gilang Muhammad Setyo Nugroho and Adhitri Anggoro and I Komang Rusgi Yandi and Bambang Pujo Semedi and Jilientasia Godrace Lilihata and Ummi Maimunah and Supriadi and Achmad Lefi and Lalu Galih Pratama Rinjani and Edi Suyanto and Ricardo Ardian Nugraha} }