@article {2384, title = {Effect of Tender Coconut Water Powder Enriched with Vitamin E in Preventing Oxidative Stress of Diabetes Male Wistar Rats}, journal = {Pharmacognosy Journal}, volume = {16}, year = {2024}, month = {October 2024}, pages = {1062-1068}, type = {Original Article}, chapter = {1062}, abstract = {

Background: Diabetes mellitus (DM) is associated with increased oxidative stress and higher mortality rates. Analysis is needed to identify compounds in natural foods that can prevent oxidative stress. According to previous studies, tender coconut waterwith added vitamin E is more effective in preventing oxidative stress caused by DM compared to plain tender coconut water. This development is necessary to provide added value and practicality. Objective: To evaluate the potential of tender coconut water powder inriched with vitamin E on male rats diabetes by measuring the oxidative stress (SOD, GPx, MDA, IL-1, IL-6, TNF-α, and CRP levels). Methods: An experimental method was used with a posttest control group design. A total of 36 male Wistar rats used were randomly divided into 6 groups namely normal; DM; P1 (type 2 DM + Spray Drying tender coconut water powder); P2 (type 2 DM + Spray Drying tender coconut water powder + vitamin E); P3 (type 2 DM + Freeze Drying tender coconut water powder); and P4 (type 2 DM + Freeze Drying tender coconut water powder + vitamin E). Type 2 DM induction was carried out using Streptozotocin (STZ) 65 mg/kgBW and Nicotinamide 230 mg/kgBW. Tender coconut water powder was administered daily for 4 weeks beginning on the 3rd day after inducing DM. The data obtained were analyzed using the One Way Analysis of Variance test (ANOVA). Result: The results showed that the average levels of SOD and GPx in P4 were higher compared to P2, while MDA, IL-1, IL-6, TNF α, and CRP in P4 were lower compared to P2. Conclusion: Tender coconut water powder enriched with vitamin E effectively prevented oxidative stress, as indicated by increased SOD and GPx, along with decreased MDA, IL-1, IL-6, TNF α, and CRP levels.

}, keywords = {Tender coconut water powder; oxidative stress; Diabetes mellitus; spray drying; freeze drying}, doi = {10.5530/pj.2024.16.172}, author = {Ratnawati Ratnawati and Siti Thomas Zulaikhah and Atina Hussaana and Arrizki Azka Pratama} } @article {1897, title = {Comparison of Powdered Active Compounds Made from Tender Coconut Water Fortified with Vitamin E, Processed by Spray Drying and Freeze Drying}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {December 2022}, pages = {682-686}, type = {Original Article}, chapter = {682}, abstract = {

Background: Tender coconut water contains antioxidants vitamin C, amino acids, L-arginine, polyphenols, selenium, and minerals that prevent oxidative stress, anemia, and inflammation. It also lowers lipid profiles, increases enzyme antioxidant status, and controls lipid peroxidation. Previous investigations have shown that tender coconut water provides health benefits but is difficult to store. This is due to its short shelf life, which can be extended by drying to obtain a dry or powdered form. A special drying method to acquire dry materials and maintain the characteristics of the raw materials is spray or freeze drying. Objective: This study aims to develop tender coconut water into a powder fortified with vitamin E and to differentiate the active compound content of the powder processed by spray and freeze drying. Method: This study used a randomized block design and the sample used was green tender coconut water (Viridis variety) aged about 5-7 months from the Bogor area. The procedures include the purchase of tender coconut water, followed by spray and freeze drying, while the content of active compounds that are beneficial to health was also analyzed. Drying was carried out at the Seafast Center Laboratory of Research and Community Service Institute, Bogor Agricultural Institute (IPB), while the active compound content was analyzed at the Integrated Research and Testing Laboratory, Gadjah Mada University (UGM), Yogyakarta. Result: The active compounds analyzed from powder made from tender coconut water fortified with vitamin E were vitamin C, phenol, L-Arginine, L-Histidine, L-Lycine, L-Phenylalanine, L-Isoleucine, L-Leucine, L-Valine, and minerals consisting of Cu (Copper), Fe (Iron), Mg (Magnesium), Zn (Zinc), Na (Sodium), K (Potassium), and P (Phosphor). Conclusion: There are differences in the content of active compounds in tender coconut water powder fortified with vitamin E between freeze and spray-drying methods.

}, keywords = {Freeze drying., Spray drying, Tender coconut water}, doi = {10.5530/pj.2022.14.154}, author = {Siti Thomas Zulaikhah and Ratnawati Ratnawati and Atina Hussaana and Tjahja Muhandri} }