@article {1785, title = {Coleus atropurpureus (L) Benth. Leaves as a New Promising Drug for Abscesses Caused by Methicillin-resistant Staphylococcus aureus and Staphylococcus aureus}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {April 2022}, pages = {439-443}, type = {Research Article }, chapter = {439}, abstract = {

Background and Objective: Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus (MRSA) can cause an abscess, a skin condition with a build-up of pus due to a fluid or pus-filled tissue covering. This study aimed to determine the antibacterial activity of the ethanolic extract and its fraction from jawer kotok (Indonesian), Coleus atropurpureus (L) Benth.) against abscess-causing bacteria, S. aureus and MRSA. Materials and Methods: Laboratory Experimental Design. C. atropurpureus was collected, macerated using 96\% ethanol extract, then fractionated using ethyl acetate and n-hexane. Antibacterial properties of ethanol extract and its fraction using S. aureus ATTC 25923 and MRSA. Statistical analysis used: descriptive statistics. Results: It was found that the MIC values for S. aureus ATTC 25923 and MRSA were in the range of 0.78\% - 1.56\% w/v and the MBC value for the two test bacteria was 1.56\% Conclusions: Ethanol extract and n.hexane fraction from C. atropurpureus were new drugs for abscess treatment. It is necessary to research the formulation and evaluation of the ethanolic extract and the n-hexane fraction from C. atropurpureus against the two bacteria that cause abscesses first.

}, keywords = {Antibacterial, Coleus atropurpureus (L) Benth., Maceration, Methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus aureus ATTC 25923}, doi = {10.5530/pj.2022.14.56}, author = {Resmi Mustarichie and Yoppi Iskandar and Nyi Mekar Saptarini} } @article {1804, title = {Molecule Attachment and Prediction of ADMET Compounds in Cinnamomum burmannii on Orexin Receptor as Anti-insomnia}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {June 2022}, pages = {576-583}, type = {Research Article}, chapter = {576}, abstract = {

Background and Objectives: Insomnia is a sleep disorder characterized by a person{\textquoteright}s dissatisfaction with the quantity or quality of sleep. Suvorexant is a sedative and hypnotic drug that has been shown to be useful for the treatment of insomnia and can act more centrally and selectively on the orexin system. However, suvorexant has quite a lot of side effects. According to research, cinnamon has pharmacological benefits, one of which is anti-insomnia. The aimed this study to determine the interaction between the compounds contained in the cinnamon plant and the Orexin receptor with the molecular anchoring method and to determine the prediction of the ADMET properties of cinnamon compounds which have the potential as anti-insomniac. Material and Methods: The research method was in-silico study consisted of validation, bonding of cinnamon compounds and prediction of ADMET properties. Results: The results showed that cinnamon compounds, namely Cinnamic acid and Methylhidroxy calcone, had the best interactions with lower Gibbs bond energy values (ΔG) and inhibition constants (Ki). From the results of the prediction of ADMET properties, the Methylhydroxy calcone compound obtained positive results on the hepatotoxicity parameter and the Cinnamic acid compound obtained negative results, which means that the compound does not have toxic properties. Conclusion: The Cinnamic acid could be used as a new promising anti-insomnia agent.

}, keywords = {ADMET, Cinnamic acid, Cinnamomum burmanii, Insomnia, Orexin.}, doi = {10.5530/pj.2022.14.74}, author = {Resmi Mustarichie and Nyi Mekar Saptarini and Sandra Megantara} } @article {1778, title = {The Potential of Moringa (Moringa oleifera Lamk) Seed Oil as Anti- Alopecia}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {April 2022}, pages = {379-387}, type = {Research Article }, chapter = {379}, abstract = {

Objective: This review article aimed to examine the potentiality of moringa seed oil as anti-alopecia. Method: The data was collected by studying national and international journal articles using several search engines, namely Google and Google Scholar websites, Research Gate, Sciencedirect and Scimagojr. The keywords for this article include moringa seed oil, fatty acids, phytosterol, and anti-alopecia. Results: The result was tabulated in a table and described according to the mechanism of action of the active compounds found in moringa seed oil, fatty acids, phytosterol, and anti-alopecia. Moringa seed oil contain the phytosterol compounds (β-sitosterol, ergosterol and campesterol) show the activities that obstruct the formation of the dihydrotestosterone (DHT) compound known to be the cause of alopecia. The fatty acid compounds found in moringa seed oil (lauric acid, linoleic acid, palmitoleic acid, palmitic acid, and oleic acid) reinforce its potential to be an anti-alopecia. Conclusion: The phytosterol and fatty acid compounds supported the growth of hair to be fertile and healthy.

}, keywords = {Anti-alopecia, Fatty Acids, Moringa Seed Oil, Phytosterol}, doi = {10.5530/pj.2022.14.49}, author = {Yulius Baki Korassa and Nyi Mekar Saptarini and Resmi Mustarichie and Rini Hendriani} }