@article {1749, title = {The Potency of Cinnamon Bark Oil (Cinnamomum burmannii (Nees \& T. Nees) Blume) from 5 Regions in Indonesia as Anti- Inflammatory}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {February 2022}, pages = {154-164}, type = {Research Article}, chapter = {154-164}, abstract = {

Introduction: An alternative anti-inflammatory with milder side effects is needed. One of them can be sourced from plants such as Cinnamomum spp. Indonesia is the largest producer of cinnamon bark (Cinnamomum burmannii (Nees \& T. Nees) Blume) in the world. Thus, research is needed to increase the benefits and database of C. burmannii bark, especially as an anti-inflammatory. This study aims to determine the metabolite profile of the essential oil of C. burmannii bark (CBO) from 5 regions in Indonesia as an anti-inflammatory. Methods: The location of the sampling was carried out by fulfilling 3 criteria, namely the difference in the island, province, and the area that produces the bark of C. burmannii. Analysis was performed using GC-MS Agilent 7890B GC and 5977B MSD. A total of 40 male rats (Rattus novergicus) Wistar strain were divided into 8 groups, each group consisted of 5 rats. Group 1 as negative control treated with 1\% CMC-Na solution, group 2 as positive control treated with ibuprofen at a dose of 27 mg/kg BW, Group 3, 4, 5, 6, 7, and 8 treated with CBO from 5 locations. After 30 min of treatment, experimental animals were injected left paw with carrageenan1\%/100μl/paw. Measurements of left paw swelling were carried out at 1, 2, 3, and 4 hours and the animals were sacrificed. Edema inhibition percentage, number of inflammatory cells, and TNF-α expression were analyzed. Result: The results of this study indicate that CBO from 5 regions in Indonesia has anti-inflammatory properties. Conclusion: There was no significant difference in anti-inflammatory activity CBO from 4 regions, namely from Kerinci, Lombok Timur, Karanganyar, and Gorontalo areas.

Key words: Anti-inflammatory, Cinnamon bark Oil, Metabolite profile, Essential oil.

}, doi = {10.5530/pj.2022.14.21}, author = {Budiastuti and Rosy Dwi Nurcholida and Riesta Primaharinastiti and Sukardiman} } @article {1625, title = {Anti-Inflammatory Activity of Cinnamon Bark Oil (Cinnamomum burmannii (Nees \& T. Nees) Blume from Lombok Timur Indonesia}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {July 2021}, pages = {1005-1013}, type = {Research Article}, chapter = {1005}, abstract = {

Introduction: Research related to alternative medicine from natural ingredients that can relieve the effects of inflammation is important, especially to reduce the unwanted side effects of antiinflammatory drugs. Cinnamomum burmannii (Nees \& T. Nees) Blume is a native Indonesian species which contains essential oils and reported for its anti-inflammatory effect. Therefore, this research was conducted to determine the metabolite profile and anti-inflammatory effect of essential oil from the bark of C. burmannii (CBO) from Lombok Timur Regency. Methods: The metabolite profile of CBO was determined using Gas Chromatography-Mass Spectra (GCMS). The anti-inflammatory test was conducted used male Wistar rats. A total of 30 male rats were divided into 5 groups, each group consisting of 6 rats. Rats were injected with carrageenan 1\%/100μl/paw which had previously been given oral CBO at a dose of 30, 60, 90 mg/kg BW. Paw swelling was measured at 1, 2, 3, 4 and 5 hours after injection. The volume of edema was measured and the animals were sacrificed. The left leg was cut and preserved as material for Hematoxylin Eosin (HE) and Immunohistochemistry (IHC) preparations. The variables taken were the percentage of inhibition edema, the number of inflammatory cells by HE and the amount of TNF-α by IHC staining. Results: The results showed that there was a difference between negative control and positive control in the number of inflammatory cells and TNF-α observed in rat{\textquoteright}s paw edema. The number was less in the positive control. Likewise, when administering CBO (60 mg/kg BW and 90 mg/kg BW) the number of inflammatory cells and TNF-α was lower than the negative control. Conclusion: It can be concluded that CBO from Lombok Timur can be used as a natural anti-inflammatory agent.

}, keywords = {Cinnamomum burmannii, Immunohistochemical staining, Inflammatory cells, Metabolites profile, TNF-α}, doi = {10.5530/pj.2021.13.130}, author = {Budiastuti and Rosy Dwi Nurcholida and Riesta Primaharinastiti and Sukardiman} }