@article {1742, title = {Identification of CF Mutations and Clinical Symptoms in CBAVD Patients}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {February 2022}, pages = {98-102}, type = {Original Article}, chapter = {98}, abstract = {

CBAVD has a prevalence or morbidity rate of 1-2 percent and has an association with low sperm count and damage, including being associated with recessive inherited genetic disorders. In 1971, several men with CBAVD were identified and had an association with mild cystic fibrosis. The classic clinical symptoms of cystic fibrosis are chronic diseases of the lungs, exocrine disorders of the pancreas, increased electrolyte levels in the sweat glands. It is based on various studies that the mutation frequency in CFTR is very high in patients with CBAVD compared to non-CBAVD patients. The 5 T allele on intron 8 causes changes in amino acids that is elevated when there is translation in the mRNA. The 5 T variant is a common mutation associated with the CBAVD phenotype and clinical symptoms. The method used in writing this review article is online literature studies obtained by accessing national and international scientific journals as well as scientific articles related to CF mutation and clinical symptoms. From the results of research that has been done, mutations in CBAVD patients have differences in clinical symptoms and require further study, especially with regard to the immunological expression profile in patients using animal models.

Key words: Mutations, Clinical symptoms, CBAVD, Infectious Disease

}, doi = {10.5530/pj.2022.14.14}, author = {M Mafruchati and Jonathan Makuwira} } @article {1659, title = {Analysis of Three-Dimensional Protein Structure of CBAVD in Indonesia as a Basis for Immunotherapy to Ensure Maternal Health}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {September 2021}, pages = {1282-1286}, type = {Research Article}, chapter = {1282}, abstract = {

Introduction: Congenital Bilateral Advance Vass Deferens (CBAVD) is a birth defect characterized by azoospermia. Determine the protein structure by laboratory research was relatively difficult. The threedimensional structure of proteins is computationally analyzed as an excellent and cost-effective alternative to analyzing protein characteristics. Objective: This study has an objective to identify the three-dimensional protein structure of CBAVD in Indonesia so that it can be used to obtain drugs and immunotherapy. Method: This study uses method of DNA extraction, PCR, and sequencing in collecting the data sample. The data was analyzed using using expasy software and Swiss prot. Result: The results of this study were found 6 CBAVD proteins, four to three dimensional CBAVD protein structures and 2 CBAVD proteins that have not been identified by the three dimensional protein structure. Further studies of CBAVD protein are needed, especially those related to protein isolation and crystallography. Conclusion: The three dimensional protein can be used as immunotherapy to ensure the maternal health.

}, keywords = {CBAVD, Dimensional structure, Maternal health, Protein}, doi = {10.5530/pj.2021.13.162}, author = {Maslichah Mafruchati and Jonathan Makuwira} } @article {1623, title = {Number of research papers about Agricultural production, Meat, and Egg During COVID-19 Pandemic: Does it Changed than Before?}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {July 2021}, pages = {995-998}, type = {Research Article}, chapter = {995}, abstract = {

COVID-19 pandemic limits many physical activities of the society in public areas. The agricultural production sector is one of the important sectors in supporting the country{\textquoteright}s nutrition demand. Research is a way to maintain the productivity of the agricultural sector. This study has a purpose to analyze if pandemic COVID-19 has an impact on the number of papers about agriculture recorded by Scopus. This study uses a quantitative with secondary data analysis approach in collecting data. The samples are paper on the Scopus website contains keywords {\textquotedblleft}agriculture\& meat{\textquotedblright}, and {\textquotedblleft}agriculture\&egg{\textquotedblright}. the period of samples are during 2019-2020. The data are analyzed using Vosviewer software to show the institution with the most related topic paper. The result shows that some papers are decreasing while others are increase based on the document type. For paper related to {\textquotedblleft}agriculture{\textquotedblright} meat{\textquotedblright}, article as full type research paper increases along with review type paper. For a paper about {\textquotedblleft}agriculture \& egg{\textquotedblright}, conference type paper and review increase, while other decreases. It can be concluded that the type of paper along with the topic affects the institutions{\textquoteright} productivity in publishing papers

}, keywords = {Agricultural production, COVID-19, Egg, Meat, Research papers}, doi = {10.5530/pj.2021.13.128}, author = {Maslichah Mafruchati and Jonathan Makuwira} }