@article {1883, title = {Phytochemical Test and Acute Safety Evaluation of Oral Purple Leaves (Graptophyllum Pictum L. Griff) Extract in Rats}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {October 2022}, pages = {649-654}, type = {Research Article}, chapter = {649}, abstract = {

Background: Purple leaves (Graptophyllum pictum (L) Griff) is a native plant from Indonesia (Polynesia) which is empirically common used to treat hemorrhoids, diabetes, and many other diseases. Despite its massive development globally, there are few studies have written about the toxicity of this herbal medicine. Aim: The aim of this study is to describe the acute toxicity of this herbal medicine, as the basic ground of the further safe development of this medicine. Method: Each purple leaf dry powder (2 kg) was extracted with 15 L of 70\% ethanol and 15 L of hexane by maceration method for 3 days at room temperature and then filtered to obtain macerate liquid. The study was conducted on 36 male 6-8 weeks, Sprague{\textendash}Dawley (SD) rats. The result was presented as the mean value {\textpm} standard deviation (SD). Data were evaluated for homogeneity using Saphiro Wilk. The comparisons between pre dan post treatment body weight were measured by paired student t test and hematological measurements were analyzed by ANOVA. P value less than 0.05 was considered significant. Results: Acute toxicity of ethanol and hexane extract were assessed following a single dose administered by gavage at a dose of 50, 2000 and 3000 g/kg bw. The mean body weight of rats increased from 150 {\textpm} 2.22 g to 161 {\textpm} 6.68 g during the 14 days. The difference of body weight between before and at 14 days amongs groups were significantly different with P value \<0.01. Conclusion: The present study showed that hexane extract contains more valuable components for medical treatment purposes. The acute toxicity on 50, 2000,3000 kg/BW oral ethanol and hexane extract of Graptophyllum pictum showed no significant influence on hematological blood parameters of rats. It is safe to administered orally ethanol or hexane extract of G. pictum below 3000mg/kgBW rats.

}, keywords = {Acute, purple leaves, Safety, Toxicity}, doi = {10.5530/pj.2022.14.148}, author = {Feda Makkiyah and Eldiza Puji Rahmi and Yuni Setyaningsih} } @article {1432, title = {Graptophyllum pictum (L.) Griff. (Syn: Justicia picta Linn.) and its Effectiveness: A Well-Known Indonesian Plant}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {May 2021}, pages = {835-838}, type = {Review Article}, chapter = {835}, abstract = {

Graptophyllum pictum (L.) Griff., a shrubby stove plant, has been used traditionally to treat various diseases. This review summarizes the up-to-date data about its phytochemistry and pharmacological properties and provides a perspective and direction for future research. The phytochemical analysis of G. pictum revealed the presence of flavonoids, steroids, glycoside, tannins, saponin, chlorophyll, nontoxic alkaloid, and anthocyanin. Meanwhile, the pharmacological analysis revealed that this plant possessed various activities such as antimicrobial, immunomodulatory, antioxidant, anti-inflammation, anti-analgetic, woundhealing, anti-hemorrhoid, anti-diabetic, and estrogenic effects. However, most of its pharmacological activities were based on the crude extracts and the bioactive compounds responsible for the bioactivities have not been well identified. A further detailed investigation in phytochemistry to identify the bioactive compounds and to investigate the mechanism action of its bioactivities is required. Moreover, a toxicology study is also needed to develop a standardized formulation of G. pictum preparation and to fulfill the requirements of modern phytomedicine.

}, keywords = {Activities, G pictum, Indonesia, Pharmacological}, doi = {10.5530/pj.2021.13.106}, author = {Feda Makkiyah and Eldiza Puji Rahmi and Rika Revina and Tiwuk Susantiningsih and Yuni Setyaningsih} }