@article {2050, title = {Effectiveness of Ketapang (Terminalia cattapa L.) Extract Against Avian Pathogenic Eschericia coli (APEC) Infections in Layer Performance}, journal = {Pharmacognosy Journal}, volume = {15}, year = {2023}, month = {June 2023}, pages = {417-422}, type = {Research Article}, chapter = {417}, abstract = {

This study aimed to determine the activity of Ketapang extract (Terminalia cattapa L.) in layers infected with APEC. In vitro study that was conducted dilution methods using Ketapang extract at 5\%, 10\%, 15\%, 20\%, 25\% and 30\% concentrations. In vivo study was conducted by randomly dividing 20 layers into five treatment groups, four per group. The chickens (except in group P0-) were infected with APEC aged 24 weeks. Then, the treatment was conducted according to the divided groups in one week. The said treatments are P0- (uninfected APEC and unadministered with Ketapang extract), P0+ (infected with APEC and unadministered with Ketapang extract), and P1, P2, and P3 (infected with APEC and administered with Ketapang extract with 5\%, 10\%, and 20\% concentrations, respectively). The data from layers{\textquoteright} performance were analyzed using ANOVA and Duncan{\textquoteright}s test. The dilution method (MIC and MBC) exhibited the antibacterial ability of Ketapang extract against APEC at 5\% dose. The Ketapang extract administration in layers exhibited improved performance of chickens infected with APEC, with the administration of 10\% dose of Ketapang extract showing the best result. In summary, about 10\% concentration Ketapang extract can serve as an antibacterial agent and showed the best results in layers infected with APEC.

}, keywords = {Avian Pathogenic Escherichia coli., Food security, Layer chicken performance, Terminalia cattapa L.}, doi = {10.5530/pj.2023.15.94}, author = {Kadek Rachmawati and Rochmah Kurnijasanti and Emy Koestanti Sabdoningrum and Sin War Naw} } @article {1812, title = {Potential Roles of Purslane (Portulaca oleracea L.) as Antimetabolic Syndrome: A Review}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {June 2022}, pages = {710-714}, type = {Review Article}, chapter = {710}, abstract = {

The number of cases of obesity and type 2 diabetes mellitus (T2DM) is part of the metabolic syndrome case. Purslane (Portulaca oleracea L.) is a plant that has been clinically tested and has the potential to prevent and treat metabolic syndrome as well as pathogenic and pathophysiological activities that cause disease. The aim of this study is to discuss and conclude information regarding the activity and use of purslane (P. oleracea) as an antimetabolic. This review article is based on scientific publications found on Google Scholar and PubMed databases using the keywords of {\textquotedblleft}Portulaca obesity{\textquotedblright}, {\textquotedblleft}Portulaca overweight{\textquotedblright}, {\textquotedblleft}Portulaca dyslipidemia{\textquotedblright}, and {\textquotedblleft}Portulaca metabolic syndrome{\textquotedblright}. This plant acts on numerous pathways in the metabolic syndrome such as reduction of lipids, blood sugar, body weight and total cholesterol. Purslane (P. oleracea) can be used as a candidate for a new herbal plant as an anti-metabolic syndrome.

}, keywords = {Body weight, Insulin resistance, Metabolic syndrome, Obesity., Portulaca oleracea}, doi = {10.5530/pj.2022.14.90}, author = {Nur Sofiatul Aini and Arif Nur Muhammad Ansori and Viol Dhea Kharisma and Muhammad Farraz Syadzha and Muhammad Hermawan Widyananda and Ahmad Affan Ali Murtadlo and Rasyadan Taufiq Probojati and Md. Emdad Ullah and Sin War Naw and Vikash Jakhmola and Rahadian Zainul} } @article {1382, title = {Novel Antiviral Investigation of Annona squamosa Leaf Extract against the Dengue Virus Type-2: In vitro Study}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {March 2021}, pages = {456-462}, type = {Research Article}, chapter = {456}, abstract = {

Introduction: Dengue virus (DENV) infection is general mosquito-transmitted viral taint. It can lead to the dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Dengue is a solemn illness with no endowed antiviral medication or recognized vaccine. Therefore, we aimed to investigate the activity of Annona squamosa leaf extract (ASLE) against dengue virus type-2 (DENV-2) isolated from Surabaya, Indonesia in 2013 (NCBI accession number: KT012509). Methods: In this study, the antiviral activity of ASLE was evaluated against DENV- 2 in Vero cells using Viral ToxGlo{\texttrademark} Assay. In addition, we used CellTiter-Glo{\textregistered} Luminescent Cell Viability Assay to set the amount of viable cells in culture based on quantitation of the ATP. Results: DENV-2 replication inhibited by ASLE in Vero cells with IC50 = 73.78 μg/mL and SI = 4.49 when cells were treated two days after virus infection, whereas its CC50 for cytotoxicity to Vero cells was 331.54 μg/mL. Interestingly, this is the first report on the investigation of ASLE against DENV-2. Conclusion: In summary, ASLE demonstrated the antiviral activity against DENV-2 with less toxicity, and high possibility as a drug candidate. Therefore, it might be suggested for in vivo assessment in the progress of a potent antiviral against DENV-2.

}, keywords = {Annona squamosa, Antiviral activity, DENV-2, Vero cells}, doi = {10.5530/pj.2021.13.58}, author = {Arif Nur Muhammad Ansori and Amaq Fadholly and Annise Proboningrat and Yulanda Antonius and Suhailah Hayaza and Raden Joko Kuncoroningrat Susilo and Bilqis Inayatillah and Mada Triandala Sibero and Sin War Naw and Gabrielle Ann Villar Posa and Teguh Hari Sucipto and Soegen Soegijanto} }