@article {1376, title = {Anti-inflammatory Activity of Pegagan Embun (Hydrocotyle sibthorpioides Lam.) Plant Extract on Topical Application}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {March 2021}, pages = {411-417}, type = {Original Article}, chapter = {411}, abstract = {

Introduction: Pegagan embun (Hydrocotyle sibthorpioides Lam.) is traditionally known to have many benefits, including anti-inflammatory. Aims: This study aimed to determine the activity of ethanol extract of Pegagan Embun as an anti-inflammatory using the granuloma pouch method. Methods: This experiment used 25 male white mice and were divided into five groups, namely, the positive control group, Hydrocotyle sibthorpioides Lam. extract group with concentration 0.5\%; 1\%; 2\%, and the comparison group that given Kaltrofen{\textregistered} gel containing 2.5\% ketoprofen. Experimental animals were given carrageenan 2\% to induced the inflammation subcutaneously. The dosage form was given as much as 0.2 g topically for four days once a day. Results: Based on the results of one-way ANOVA analysis and Duncan{\textquoteright}s test, there were significant differences in exudate volume and total leukocytes (p\<0.05) in the positive control group, extract with concentration 0.5\%, 1\%, 2\%, and the comparator. While the percentage of leukocyte cells showed that they were not significantly different (p\>0.05), the number of neutrophil cells decreased. Conclusion: From the overall data obtained, it can be concluded that the extract of Hydrocotyle sibthorpioides Lam. at concentration 0.5 \%; 1\%; 2\%, has an anti-inflammatory effect.

}, keywords = {Anti-inflammatory, Exudate, Gel, Hydrocotyle sibthorpioides Lam., Ketoprofen, Leukocytes}, doi = {10.5530/pj.2021.13.52}, author = {Afriwardi and Rahmatul Nazmi and Dwisari Dillasamola and Elsa Badriyya and Yufri Aldi} }