@article {1372, title = {Characterization and Acute Toxicity Bioactive Compound Canning Waste of Lemuru Fish Oil as Potential Immunomodulator}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {March 2021}, pages = {376-382}, type = {Original Article}, chapter = {376}, abstract = {

Background: Poly Unsaturated Fatty Acids have beneficial effects as an immunomodulator for periodontitis therapy. Lipid studies show that fish can be a unique source of polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid. Lemuru fish (Sardinella longicep) is one of fish that abbundant in Indonesia. Purpose: This study aims to find out the characterization and acute toxicity of lemuru fish oil for using in dental treatment. Methods: characterization study was tested using capillary gas chromatography coupled method with flame ionization. Acute toxicity performed by given lemuru orally with dose 174.1-917.3mg/20g mice weight for 24 hours observation and sacrificed for histopathology, meanwhile groups 96 hours observation continued. Results: Lemuru Fish oil contains 14.5\% eicosapentaenoic acid and 13,2\% Docosahexaenoic Acid. Acute toxicity showed the percentage of death below 50\%, however, liver structure start to show an effect on dose 355.3mg/20gr Conclusion: Lemuru Fish oil had a component Poly Unsaturated Fatty Acids an potential immunomodulator. There was no acute toxicity found and the maximum dose without changing the microscopic structure of the liver is 174.1mg / 20gr.

}, keywords = {Docosahexaenoic acid, Eicosapentaenoic acid, Lemuru fish oil, Polyunsaturated fatty acid, Toxicity}, doi = {10.5530/pj.2021.13.48}, author = {Damaiyanti DW and Sari RP and Muwarmanti D} }