@article {1702, title = {Syzygium polyanthum (Wight.) Walp Ethanol Extract Decreased Malondialdehyde Level in Type 2 Diabetic Patients}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {December 2021}, pages = {1557-1561}, type = {Original Article}, chapter = {1557}, abstract = {

Background: Beside conventional oral antidiabetic, many diabetic patients used plant as an alternative medicine. One of the plants is Syzygium polyanthum Wight. Walp. Previous study showed that ethanolic extract of Syzygium polyanthum (Wight.) Walp leaves (EESP) is safe to be consumed by healthy volunteer. Aim: The present study was conducted to investigate the effect of EESP on malondialdehyde (MDA) level in type 2 diabetes mellitus volunteers. Materials and Methods: EESP was obtained by maceration then formulated in capsules (weight of 350 mg). A total of 12 volunteers were randomly given EESP or Placebo/ Pl (amylum) once daily for 14 days in conjunction with metformin 500 mg twice daily. Hemoglobin (Hb), liver and kidney function and MDA were measured at the beginning and at the end of the study. Results: After 14 days administration of EESP, Hb 12.52{\textpm} 1.23 (g/dL), SGOT 24.16{\textpm}13.57 (U/L), SGPT 27.50 {\textpm} 20.52 (U/L), ureum 23.12{\textpm}13.27 (mg/dL), creatinine 0.71 {\textpm} 0.23 (mg/dL) while MDA 1041.63 {\textpm} 615.66 ng/mL in EESP treated group. The reduction of MDA level in EESP-treated group (24\%) were higher than Pl-treated group (16\%). Conclusion: S. polyanthum leaf extract is potential as antioxidant in type 2 diabetes mellitus patients.

}, keywords = {Diabetes mellitus; Extract; Malondialdehyde; S. polyanthum}, doi = {10.5530/pj.2021.13.198}, author = {Tri Widyawati and M. Aron Pase and Milahayati Daulay and Imam Bagus Sumantri} } @article {1303, title = {Evaluation of Myrmecodia pendans Water Extracts on Hematology Profiles, Liver, Kidney Function and Malondialdehyde Level in Healthy Volunteer}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {November 2020}, pages = {1489-1493}, type = {Original Article}, chapter = {1489}, abstract = {

Background: Ant Nest (Myrmecodia pendans) is one of plants that have been used by locals in Indonesia to empirically treat various diseases. Ant Nest in vitro and in vivo studies on animals have been widely reported its pharmacological activities as an antioxidant. Unfortunately, scientific proofs reported on this plant as human medicine are still lacking. Aim: This study aimed to ensure effectiveness, and safety due to administration of Ant Nest Water Extract (ANWE) formulated in capsule. Materials and Methods: Twelve volunteers were divided into 2 groups, 6 volunteers in each group. Group I: Ant Nest Water Extract Capsule (ANWEC) in dose of 350 mg ANWE, and group II: Placebo Capsule (PC) which contained 350 mg amylum. Each groups given the capsule once daily for 28 days. The comparison was made between group I and group II. Hematology tests include hemoglobin, leucocyte and thrombocyte. Blood chemistry tests include SGOT, SGPT, total cholesterol, triglycerides, HDL, LDL, glucose, ureum (Ur) and creatinine (Cr). Malondialdehyde (MDA) level was measured at day-28 which was the last day of the intervention. Results: After 28 days administration of ANWE, the SGOT, SGPT, Ur, and Cr showed in normal level as follows SGOT (U/L): 19.2 {\textpm} 3.99; SGPT (U/L): 17.2 {\textpm} 6.80; Ur (mg/dL): 19.75 {\textpm} 3.66; Cr (mg/dL): 1.06 {\textpm} 0.13. MDA (ng/mL) level in ANWEC-treated group was significantly lower (117.2{\textpm}23.8) than PC (147.25{\textpm}18.7). There was no intolerable complaints during the observation. Conclusion: The study concluded that Water Extract of Ant Nest 350 mg has no damage to liver, kidney and hematology, so it was proven that this plant is safed to be consumed by human for its potency as antioxidant.

}, keywords = {Antioxidant, Malondialdehyde, Myrmecodia pendans, Safety}, doi = {10.5530/pj.2020.12.204}, author = {Tri Widyawati and M Aron Pase and Milahayati Daulay and Imam Bagus Sumantri and Nor Adlin Yusoff} }