@article {1663, title = {Potential Neuroprotective Activity of Essential Oils in Memory and Learning Impairment}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {September 2021}, pages = {1312-1322}, type = {Review article}, chapter = {1312}, abstract = {

Memory and learning is negatively affected by many factors. Alzheimer{\textquoteright}s disease is a progressive and irreversible neurological disorder that occurs gradually, a sickness that is increasingly common, and multiple scientific articles suggest that essential oils improve memory and learning and are useful in the treatment of various neurodegenerative diseases, including Alzheimer{\textquoteright}s disease. This review aims to conduct a critical collection of current information on research into both memory and learning impairment, as well as essential oils that are able to avoid this neurodegenerative disease. Currently, different animal models have been useful for the study of neurodegenerative problems that alter memory and learning, experimental pharmacological, genetic and toxicological models that can simulate specific cognitive deficit syndromes. In addition, research in this review show several essential oil compounds that present positive results in animal studies, but still lack human clinical trials. Therefore, the assessment of the safety and efficacy of these phytochemical compounds in diseases that cause memory impairment and learning, remain a promising area for future research.

}, keywords = {Alzheimer disease, Animal model, Essential oil, Learning, Memory, Neurodegenerative diseases}, doi = {10.5530/pj.2021.13.166}, author = {Carmen R. Silva-Correa and Jorge L. Campos-Reyna and V{\'\i}ctor E. Villarreal-La Torre and Abhel A. Calder{\'o}n-Pe{\~n}a and William Antonio Sag{\'a}stegui-Guarniz and Luz M. Guerrero-Espino and Anabel D Gonz{\'a}lez-Siccha and Cinthya L. Aspajo-Villalaz and Mar{\'\i}a V. Gonz{\'a}lez-Blas and Jos{\'e} L. Cruzado-Razco and Julio Hilario-Vargas} } @article {1242, title = {Wound Healing Activity of an Ointment from Solanum tuberosum L. "Tumbay Yellow Potato" on Mus musculus Balb/c}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {September 2020}, pages = {1268-1275}, type = {Original Article}, chapter = {1268}, abstract = {

Background: Solanum tuberosum L. is an Andean tuber that is mainly characterized by its antioxidant properties. Objective: To evaluate the healing activity of an S. tuberosum-based ointment on wounds induced in mice. Material and methods: Ethanolic extracts of peel and pulp of tubers of S. tuberosum "Tumbay yellow potato" were prepared, which were incorporated into 1\% and 2\% ointment formulations. Mus musculus Balb/c with induced wound were distributed in the following working groups: Group I (Negative Control), Group II (Positive Control: Neomycin, Polymyxin B and Bacitracin Ointment) and Groups III and IV (Ointment at 1 \% and 2\% of S. tuberosum extract, respectively), daily administration of topical treatments were carried out for 07 days. Wound closure was determined during the experimentation time, then euthanized with sodium pentobarbital 60 mg/kg b.w. (i.p.) to obtain skin samples for histopathological analysis. Results: Groups III and IV showed that better evidence of wound closure and scarring in the histopathological analysis, the greatest effect being in Group IV. Conclusions: S. tuberosum ointments show healing activity in induced wounds in mice, the most effective treatment being the 2\% ointment formulation.

}, keywords = {Histology, Skin, Solanum tuberosum, Wound Healing, Yellow potato}, doi = {10.5530/pj.2020.12.175}, author = {Galy P Rosas-Cruz and Carmen R Silva-Correa and Abhel A Calder{\'o}n-Pe{\~n}a and V{\'\i}ctor E Villarreal-La Torre and Cinthya L Aspajo-Villalaz and Jos{\'e} L. Cruzado-Razco and Jorge Del Rosario-Ch{\'a}varri and Juan C Rodr{\'\i}guez-Soto and Orlando E Pretel-Sevillano and William Antonio Sag{\'a}stegui-Guarniz and Anabel D Gonz{\'a}lez-Siccha} }