@article {1751, title = {Antimicrobial Compound from Endophytic Pseudomonas azotoformans UICC B-91 of Neesia altissima (Malvaceae)}, journal = {Pharmacognosy Journal}, volume = {14}, year = {2022}, month = {February 2022}, pages = {172-181}, type = {Research Article}, chapter = {127}, abstract = {

Centrifugated extract of endophytic Pseudomonas azotoformans strain UICC B-91 has been observed for its antimicrobial activity against Escherichia coli ATCC 8739, Bacillus cereus ATCC 10876, Staphylococcus aureus ATCC 6583, Staphylococcus aureus ATCC 25923, Salmonella typhimurium ATCC 25241, Pseudomonas aeruginosa ATCC 15442, Bacillus subtilis ATCC 19659 and Candida albicans ATCC 10231, with minimum concentration in the range 250 μg/mL. But, the novel compound of the bioactive substances which relevant for antimicrobial activity have not been described. Further fractionation and identification of the extract by thin layer chromatography (TLC) and liquid chromatography mass spectrophotometry (LCMS-MS) detected several compound as futoamide (C18H23NO3), gentialutine (C9H11NO), gentiabetine (C9H11NO2), 1-[(2E,4E)-2,4-decadienoyl]pyrrolidine (C14H23NO), lycopodine (C16H25NO) and dihydrolycopodine (C16H27NO). The majority compounds containing CHON elements with molecular weight approximately 100-450 Da.

Keywords: Alkaloid, Antimicrobial compound, Extraction, P. azotoformans.

}, doi = {10.5530/pj.2022.14.23}, author = {Rina Hidayati Pratiwi and Eva Oktarina and Wibowo Mangunwardoyo and Iman Hidayat and Endang Saepudin} } @article {1157, title = {A Review on Genus Saurauia: Chemical Compounds and their Biological Activity}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {May 2020}, pages = {657-666}, type = {Review Article}, chapter = {657}, abstract = {

Introduction: Saurauia plant has been widely used to treat a variety of diseases suffered by villagers at various places in the world. These species are widely used traditionally by the community as antidiabetic and digestive problems{\textquoteright} remedy. This paper will present various uses and researches ever carried out by researchers in the world on various types of the genus Saurauia. Methods: The Information was collected from scientific journals, books, and reports. Results: This review summarizes the existing information on several species of Saurauia in relation to their chemical compounds and biological activity. There are some of chemical compounds present and identified in Saurauia, i.e. 3β-hydroxy-Olean-12-en- 28oic acid; 3,19-Dihydroxyurs-12-en-28-oic acid; 3-hidroksi, 12(13)-en, 28-oleanolat acid; actinidin; several monoterpene lactones; seven triterpenoids, namely, cis-3-O-p-hydroxycinnamoyl ursolic acid; trans-3-O-p-hydroxycinnamoyl ursolic acid; ursolic acid; oleanolic acid; corosolic acid; maslinic acid; and β-amyrin; and two steroids, stigmasterol; and β-sitosterol. There are several biological activities afforded by Saurauia i.e. antioxidant activity, anti-cholesterol, antidiabetic activity, antihyperlipidemic, analgetic activity, antimicrobial activity, wound-healing activity and immunostimulatory activity.

}, keywords = {Biological activity, Chemical compounds, Human disease remedy, Saurauia}, doi = {10.5530/pj.2020.12.97 }, author = {Gunawan Pasaribu and Emil Budianto and Herry Cahyana and Endang Saepudin} }