@article {1102, title = {Antidiabetic Constituents from Helminthostachys zeylanica (L) Hook (Ophioglossaceae)}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {March 2020}, pages = {223-226}, type = {Original Article}, chapter = {223}, abstract = {

Background: The roots of tunjuk langit (Helminthostacshys zeylanica) have been used traditionally in some villages in Indonesia, particularly in Riau Province. Objective: In this study we reported two flavonoids and their antidiabetic activity. Material and methods: Isolation of the metabolites was based on polarity fractionation method. Purification processes were conducted by vacuum liquid chromatography (VLC). Chemical structures were elucidated based on spectroscopy characteristics, including FTIR and 1D/2D NMR. Results: The isolated compounds were identified as ugonin J and K. The antidiabetic activity was measured by α-glucosidase inhibitor assay. The antidiabetic activity of ugonin J was found at IC50 273,13{\textpm}0,402 ppm and Ugonin K was found at IC50 138,21{\textpm}0,263 ppm (moderately active). Conclusion: Therefore this plant can be used traditionally as antidiabetic medicine.

}, keywords = {Antidiabetic, Helminthostacys zeylanica, Ophioglossaceae, α-glucosidase}, doi = {10.5530/pj.2020.12.33}, author = {Fania El Ridhasya and Novia Rahim and Muhammad Almurdani and Rudi Hendra and Hilwan Yuda Teruna} } @article {1109, title = {Antioxidant and Antidiabetic Activities of Mempening (Lithocarpus bancanus) Leaves}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {March 2020}, pages = {328-334}, type = {Original Article}, chapter = {328}, abstract = {

Background: Lithocarpus bancanus or commonly called as mempening in Talang Mamak Tribe, Indonesia is a plant that is used as a traditional medicine. Objective: This study aim to evaluated antioxidant and antidiabetic activities of L. bancanus leaves extract. Material and Methods: The methanol extract was obtained by maceration of the leaves. The n-hexane, dichloromethane and ethyl acetate fractions were prepared by successive partition process of the methanol extract. Antioxidant activities were evaluated by various antioxidant assays, including DPPH (1,1-diphenyl-2-picrylhydrazyl), FRAP (ferric reducing antioxidant power), CUPRAC (cupric reducing antioxidant capacity), and ABTS (2,2{\textquoteright}-azonobis 3-ethylbenzothiazoline-6-sulfonic acid) method. Total phenolics were estimated based on the Folin{\textendash}Ciocalteu method, while, aluminum chloride methods were employed to estimate total flavonoids. Antidiabetic activies was determined by inhibiting the activity of α-glucosidase method. Results: antioxidant activity assay against DPPH radical as well as the total phenolic and flavonoid content of L. bancanus leaves showed that the methanol extract possessed IC50 value of 39.469 {\textpm} 0.273 μg/mL with total phenol and flavonoid were 11.426 {\textpm} 0.432 mg GAE/g dry weight sample and 15.423 {\textpm} 0.213 mg QE/g respectively. The FRAP, CUPRAC and ABTS values of methanol extract were 3494.302 {\textpm}0.456, 26665.501 {\textpm} 5.940 and 2857.977 {\textpm} 0.715 μM TE/g dry weight sample respectively. Antidiabetic activity of methanol extract with IC50 value of 30.565 {\textpm} 0.331 μg/mL. Conclusion: It could be concluded that leaves of L. bancanus have antioxidant and antidiabetic properties.

}, keywords = {Antidiabetic, Antioxidant, Lithocarpus bancanus, Talang Mamak Tribe}, doi = {10.5530/pj.2020.12.52}, author = {Muhammad Almurdani and Adel Zamri and Titania T Nugroho and Jasril Karim and Yum Eryanti and Rudi Hendra and Hilwan Yuda Teruna} }