@article {1634, title = {Chitosan-Tripolyphosphate Nanoparticles of Mango Ginger (Curcuma mangga) Extract: Phytochemical Screening, Formulation, Characterization, and Antioxidant Activity}, journal = {Pharmacognosy Journal}, volume = {13}, year = {2021}, month = {September 2021}, pages = {1065-1071}, type = {Original Article}, chapter = {1065}, abstract = {

Introduction: Mango ginger (Curcuma mangga) is one of Indonesia{\textquoteright}s medicinal plants widely used in most communities as a lust booster and for detoxifying purposes. Therefore, the purpose of this study is to synthesize chitosan-tripolyphosphate nanoparticles from mango ginger extract, determine their chemical contents, the nano chitosan characteristics, and its antioxidant activity. Methods: In this study, we macerated mango ginger using 70\% ethanol solvent, then performed phytochemical test and formulation of chitosan nanoparticles of mango ginger extract. The group of secondary metabolites that showed positive results with the reagent test was further identified through TLC. Results: The results showed that the extract contained flavonoids and triterpenoids. Also, characterization of chitosan nanoparticles from the extract was conducted with FTIR test, PSA, XRD, and SEM. Based on the results, the nano chitosan particle size was 993 nm and examination with FTIR showed the presence of N-H and P=O groups, indicating ammonium ion interaction from chitosan with the polyanion from TPP and Mango ginger. Additionally, the XRD results showed that the crystals formed were in an amorphous form, which was supported by particle morphology images from SEM. Furthermore, the nanoparticles showed very strong antioxidant activity based on the reaction with DPPH. Conclusion: Based on these results, the phytochemical identification of mango ginger extract showed positive results in flavonoid and triterpenoid compounds. In addition, based on the characterization of the nanoparticles, the mango ginger extract showed positive results, illustrating that the nano chitosan synthesis was successful. Furthermore, the nano chitosan has a very strong antioxidant activity with an IC50 value of 18.08 μg/mL.

}, keywords = {Chemical identification, Chitosan, Mango ginger, Nanoparticles, TPP}, doi = {10.5530/pj.2021.13.138}, author = {Bayyinatul Muchtaromah and Didik Wahyudi and Mujahidin Ahmad and Arif Nur Muhammad Ansori and Rahmi Annisa and Lil Hanifah} } @article {1092, title = {Efficacy of Allium sativum, Curcuma mangga and Acorus calamus Extract Combination on Rat Fertility}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {February 2020}, pages = {197-203}, type = {Research Article}, chapter = {197}, abstract = {

Objective: to evaluate the efficacy of Allium sativum, Curcuma mangga, and Acorus calamus extract combination on female rat fertility. Methods: Thirty-six female rats were randomized divided into 9 groups (n=4): C- (no treatment); C+ (clomiphene citrate); composition 1 (A. sativum 36\%: C. mangga 36\%: A. calamus 28\%) with 3 doses i.e T1, T2 \& T3 of 50, 75 \& 100 mg/kg BW; composition 2 (A. sativum 35\%: C. mangga 40\%: A. calamus 25\%) with 3 doses i.e T4, T5 \& T6 of 50, 75 \& 100 mg/kg BW and T7 (Subur Kandungan herb{\texttrademark}). Treatment was given every day for 15 days. Results: The results revealed that all treatments affected reproductive hormone and uterine histology profile. However, T1 produced the highest estrogen and progesterone levels, and T2 produced the highest endometrial and myometrium thickness, as well as the number of endometrial glands. Furthermore, the hormonal profile in T1 and histological profile of uterus in T2 were not significantly different from those of T7 group. Conclusions: Combined A. sativum, C. mangga, and A. calamus extracts could be used to increase fertility in female rat. The most effective treatment in this study was dose of 50-75 mg/BW in both compositions.

}, keywords = {Acorus calamus, Allium sativum, Curcuma mangga, Fertility, Rat}, doi = {10.5530/pj.2020.12.30}, author = {Bayyinatul Muchtaromah and Roihatul Muti{\textquoteright}ah and Desy Rahma Yusmalasari and Putri Mardyana and Tanjina Sharmin} } @article {1233, title = {Nanoparticle Characterization of Allium sativum, Curcuma mangga and Acorus calamus as a Basic of Nanotechnology on Jamu Subur Kandungan Madura}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {August 2020}, pages = {1152-1159}, type = {Research Article}, chapter = {1152}, abstract = {

Introduction: The increasing of researcher attraction on the herbal drug after so long ignored due to difficulties in processing has opened a new door for the development of a novel of "jamu Subur Kandungan". However, the constraints that then faced in consuming "jamu Subur Kandungan", an herbal reproductive drug, are the solubility and poor absorption in the intestine. Therefore, this study aims to characterize nanoparticle of the combination of garlic (Allium sativum), temu mangga (Curcuma mangga) and jeringau (Acorus calamus) encapsulated by chitosan. Material and Methods: the simplicial of garlic (Allium sativum), temu mangga (Curcuma mangga) and jeringau (Acorus calamus) was purchased from Materia Medica Batu Malang Indonesia. Nanoparticle of combination of garlic, temu mangga and jeringau was produced by ionic gelation method. Nanoparticle characterization was assessed by Scanning electron microscopy (SEM), Spectrophotometer Fourier Transform Infra-Red (FTIR), Particle Size analyzer (PSA) and X-ray diffraction (XRD). Result: The ionic gelation method succeeded to make nanoparticle. The produced nanoparticle was around 438-1159 nm. The length of sonication has proven to make the particle size smaller. The particle size distribution of chitosan at the time of 90 min sonication and 150 min was classified as uneven because of the particle size clustered in the range 500-1000 nm and 3000-5000 nm. The hydroxyl (OH) group appeared at wave number 3429-2466 cm-1, while the amide functional group appeared at wave numbers (1648-1652 cm-1. Phosphate groups (P = O) also appeared, which is a TPP residue, at a wavenumber 1384 cm-1. Conclusion: Chitosan-garlic nanoparticles (Allium sativum), temu mangga (Curcuma mangga) and jeringau (Acorus calamus) were successfully produced with ionic gelation method.

}, keywords = {Characterization, Garlic, Ionic gelation, Jeringau, Nanoparticle, Temu mangga}, doi = {10.5530/pj.2020.12.162}, author = {Bayyinatul Muchtaromah and Didik Wahyudi and Mujahidin Ahmad and Rahmi Annisa} }