@article {1084, title = {Beautyberry (Callicarpa arborea) as an Antiparasitic Agent Against Raillietina echinobothrida, an Intestinal Tapeworm}, journal = {Pharmacognosy Journal}, volume = {12}, year = {2020}, month = {February 2020}, pages = {66-70}, type = {Original Article}, chapter = {66}, abstract = {

Background: The beautyberry (Callicarpa arborea Roxb.) is member of the family Lamiaceae and is native to Asia. It is used in different traditional medicines for the treatment of debilitating ailments including cancer, dermatitis, diabetes mellitus, gastritis, helminthiasis, and pyrexia. A couple of pentacyclic triterpenes and phytosterols have been reported from this plant. Objective: We aimed to investigate the antiparasitic potentials of C. arborea bark extract. We used an intestinal tapeworm, Raillietina echinobothrida, for its convenience in handling and established nature as a model helminth parasite. Materials and Methods: The extract of the stem bark was prepared using methanol. Tapeworms were treated in vitro with varying concentrations of the extract. Survival values were statistically analysed. Treated tapeworms were fixed and processed for scanning electron microscopy. Results: C. arborea bark extract showed dose-dependent antiparasitic similar to that of albendazole. Scanning electron microscopy revealed damaging effects all over the body of the tapeworm. There was general shrinkage of the tegument on the scolex, neck region and strobila. Microtriches were completely removed throughout the tegument. Suckers and rostellum on the scolex were also deformed. Conclusion: Our data shows that C. arborea is a promising source of antiparasitic principles.

}, keywords = {Callicarpa arborea, Scanning electron microscopy, Tapeworm, Tegument}, doi = {10.5530/pj.2020.12.11}, author = {P.B. Lalthanpuii and Kholhring Lalchhandama} } @article {1044, title = {Anthelmintic Activity of Millettia pachycarpa Root Bark Extract on an Intestinal Roundworm, Ascaridia galli}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {November 2019}, pages = {1428-1433}, type = {Original Article}, chapter = {1428}, abstract = {

Background: Millettia pachycarpa Benth. is member of the family Fabaceae and is a wellknown traditional medicinal plant used for different health conditions. Its roots and seeds are rich in bioactive compounds such as chalcones, isoflavones and rotenoids, which are attributed to the anticancer, antiparasitic and insecticidal properties of the plant. In Mizo traditional medicine, the root bark is also used for parasitic infections. Objective: The study was designed to understand the anthelmintic efficacy and effects of M. pachycarpa on an intestinal roundworm, Ascaridia galli. Materials and Methods: The methanolic extract of the root bark was prepared and survival test was performed against A. galli. The structural effects were studied using scanning electron microscopy and histological preparations. Results: The roundworm showed extensive structural changes and damages. The cuticle showed extensive shrinkage and cracks. Lacerations and scars distorted the fine transverse rings. The mouthparts collapsed with shrunken lips and degenerated denticles. Internal tissues such as musculature and reproductive organs were also impaired. Conclusion: The findings indicate that the plant extract is effective against parasitic roundworms.

}, keywords = {Ascaridia galli, Cuticle, microscopy, Millettia pachycarpa, Roundworm}, doi = {10.5530/pj.2019.11.221}, author = {Kholhring Lalchhandama} }