@article {957, title = {Optimization Method for Determination of Swelling Factor Linum usitatissimum Seeds}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {September 2019}, pages = {936-943}, type = {Original Article}, chapter = {936}, abstract = {

Aim: Aspire of the investigation is to amend the method for determination of swelling factor of seeds, so it can be determined to optimize the minimum errors which will be reproducible. Swelling factor is play key role if the phytoconsitituent rich in mucilage and polysaccharide which constitute a diverse class of biological macromolecules. Background: Sugar molecules play a broad range of physiochemical properties which are widely used for applications in Pharmacy and the present investigation work is related to determine the effect of parameters such as quantity of seed, volume and nature of solvent, time interval of agitation, time of measurement of result, Effect of quantity of seeds on swelling factor determination. Solvent Optimized technic gives superlative results over IP method. Methods: The swelling factor of Linum usitatissimum was evaluated by using different polar to non-polar solvents by using the standard procedure. During the determination, the role of physical parameter were calculated by comprising the swelling factor with agitation and temperature. Results: According to the observations, the lower concentration levels of swelling index used as an alternative binder to starch. keeping one parameter as variable while all other parameters constant, it was observed that the swelling index of gives better results using the solvents plain distilled water, seeds moistened with alcohol. It was also observed that agitation at every three hours till the process of 24 hours is maintained would give better results, keeping one parameter as variable while all other parameters constant.

}, keywords = {Formulation parameter, Seed, Swelling index}, doi = {10.5530/pj.2019.11.149}, author = {S Dhanalakshmi and C N Hemalatha and Sai Ramya Bharathi and C Dhivya and S Vanishree and V Rekha and V Vijayalakshmi and A Hari priya and Sai Monisha} }