@article {973, title = {Chemical Standardization of Thetran Vithai Kutinir Chooranam-An Antidiabetic Siddha Polyherbal Formulation}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {September 2019}, pages = {1106-1113}, type = {Research Article}, chapter = {1106}, abstract = {

Introduction: Belief of general public on herbal drugs led to the stable growth of herbal drug industry thereby necessitated the standardization of herbal drugs and pharmacopoeial standards for their quality control. Aims: Thetran Vithai Kutinir Chooranam (TVKC) is a Siddha polyherbal formulation used for type II diabetes. Aim of the present study is to standardize the drug chemically. Methods and Material: Drug was prepared as per the literature, stored in air tight container and subjected to preliminary phytochemical analysis, physico-chemical, thin layer chromatographic photo documentation, high performance thin layer chromatographic finger printing along with chemical markers such as emodin, chrysophanol and gallic acid, quantitative assay of marker compounds, heavy metal analysis, pesticide residue, aflatoxin and microbial load analysis. Results: The results revealed that the drug contains emodin in minor quantity and gallic acid in considerable quantity. The drug is free from microbial, heavy metal contaminations, aflatoxin and pesticide residues. Conclusion: The derived results could serve as a ready reference for quality control assessment of the drug.

}, keywords = {Anthraquinone, Katukkai, Thetranvithai, Vilam Pisin Alkaloid}, doi = {10.5530/pj.2019.11.173}, author = {Elankani P and Murugammal S and Shakila R and Pitchiahkumar M and N.Kabilan} } @article {906, title = {Exploration of Anti-Urolithiasis Potential of Traditional Siddha Formulations Amukkara Chooranam and Karisalai Karpam Chooranam by Struvite Crystal Growth Inhibition Assay}, journal = {Pharmacognosy Journal}, volume = {11}, year = {2019}, month = {July 2019}, pages = {683-688}, type = {Original Article}, chapter = {683}, abstract = {

Background: Urolithiasis is a medical condition characterized by formation of stone which comprises of calcium oxalate, magnesium ammonium phosphate and uric acid. Reoccurrence becomes the primary hindering factor in providing relief for urolithiasis; hence there is a need of alternate therapeutic strategy that may effectively combat and halt the formation and nucleation of the crystals. Objective: The main aim of the present investigation is to explore the anti-urolithiasis potential of the two versatile siddha formulations Amukkara Chooranam (AKC) and Karisalai Karpam Chooranam (KKC) using diffusion gel growth technique. Materials and Methods: Silica hydrogel matrix was divided in to three groups which were control, AKC and KKC treated groups. Test drugs were screened at two dose levels of 0.5\% and 1\%. The efficiency of the formulations was screened by comparing the crystal size of the control and treatment medium. Results: The average size of the crystals in the control medium was found to be 2.12 {\textpm} 0.22 cm, whereas the crystal size was significantly decreased in medium contains 0.5\% and 1\% of AKC with the size of 1.4 {\textpm} 0.15 and 1.14 {\textpm} 0.18 cm. Similar type of findings were observed in medium consist of 0.5\% and 1 \% KKC with the size of 1.52 {\textpm} 0.13 and 1.08 {\textpm} 0.17 cm. Conclusion: Results clearly indicates that both the siddha formulations offers maximum percentage inhibition on the crystal growth in the tested medium, this efficacy may be due to presence of versatile phytocomponents present in the formulations.

}, keywords = {Amukkara Chooranam, Crystals, Karisalai karpam chooranam, Lithotripsy, Polyherbal, Traditional medicines}, doi = {10.5530/pj.2019.11.108}, author = {D.Sivaraman and N.Anbu and N.Kabilan and M.Pitchiah Kumar and P.Shanmugapriya and G.J.Christian} }